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Kat6b K(lysine) acetyltransferase 6B [ Mus musculus (house mouse) ]

Gene ID: 54169, updated on 11-Apr-2024

Summary

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Official Symbol
Kat6bprovided by MGI
Official Full Name
K(lysine) acetyltransferase 6Bprovided by MGI
Primary source
MGI:MGI:1858746
See related
Ensembl:ENSMUSG00000021767 AllianceGenome:MGI:1858746
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
qkf; Morf; Myst4; MYST-4; querkopf; mKIAA0383; B130044K16Rik
Summary
Enables histone acetyltransferase activity. Acts upstream of or within cellular response to leukemia inhibitory factor and histone acetylation. Predicted to be located in nucleus. Predicted to be part of MOZ/MORF histone acetyltransferase complex. Is expressed in several structures, including brain; early conceptus; facial prominence; genitourinary system; and limb mesenchyme. Used to study Noonan syndrome. Human ortholog(s) of this gene implicated in bipolar disorder; blepharophimosis-intellectual disability syndrome, SBBYS type; breast cancer; and leiomyoma. Orthologous to human KAT6B (lysine acetyltransferase 6B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in limb E14.5 (RPKM 5.4), frontal lobe adult (RPKM 5.1) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
14 A3; 14 11.73 cM
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (21549284..21722546)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (21499216..21672478)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_36127 Neighboring gene adenosine kinase Neighboring gene VISTA enhancer mm1738 Neighboring gene STARR-seq mESC enhancer starr_36134 Neighboring gene predicted gene, 30363 Neighboring gene STARR-positive B cell enhancer ABC_E8945 Neighboring gene STARR-positive B cell enhancer ABC_E605 Neighboring gene STARR-positive B cell enhancer ABC_E4100 Neighboring gene STARR-seq mESC enhancer starr_36143 Neighboring gene STARR-seq mESC enhancer starr_36148 Neighboring gene VISTA enhancer mm1600 Neighboring gene dual specificity phosphatase 29 Neighboring gene dual specificity phosphatase 13B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Aging-associated decrease in the histone acetyltransferase KAT6B is linked to altered hematopoietic stem cell differentiation. Khokhar ES, et al. Exp Hematol, 2020 Feb. PMID 32014431, Free PMC Article
  2. [KAT6B promotes LPS-triggered IL-6 production via enhancing recruitment of H3K23 acetylation to IL-6 promoter region]. Sun D, et al. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi, 2017 Nov. PMID 29268844
  3. The transcriptional coactivator Querkopf controls adult neurogenesis. Merson TD, et al. J Neurosci, 2006 Nov 1. PMID 17079664, Free PMC Article
  4. Querkopf, a histone acetyltransferase, is essential for embryonic neurogenesis. Thomas T, et al. Front Biosci, 2004 Jan 1. PMID 14766340
  5. Querkopf is a key marker of self-renewal and multipotency of adult neural stem cells. Sheikh BN, et al. J Cell Sci, 2012 Jan 15. PMID 22331353

See all (49) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SNORD17-mediated KAT6B mRNA 2'-O-methylation regulates vasculogenic mimicry in glioblastoma cells.
    Title: SNORD17-mediated KAT6B mRNA 2'-O-methylation regulates vasculogenic mimicry in glioblastoma cells.
  2. work identifies KAT6B as a novel epigenetic regulator of hematopoietic differentiation and a target to improve aged immune function.
    Title: Aging-associated decrease in the histone acetyltransferase KAT6B is linked to altered hematopoietic stem cell differentiation.
  3. Fluorescence correlation spectroscopy analyses suggest a more compact chromatin organization in K6b-/- cells and impaired interactions of Oct4 and Nanog with chromatin.
    Title: Kat6b Modulates Oct4 and Nanog Binding to Chromatin in Embryonic Stem Cells and Is Required for Efficient Neural Differentiation.
  4. Silence of lysine acetyltransferase 6B (KAT6B) suppressed lipopolysaccharide(LPS)-induced IL-6 production in peritoneal macrophages.
    Title: [KAT6B promotes LPS-triggered IL-6 production via enhancing recruitment of H3K23 acetylation to IL-6 promoter region].
  5. Data indicate that Myst4, Jmjd2b, Aof1 genes are regulated by H3K9me under hyperinsulinemia/hyperglycemia.
    Title: Histone H3 lysine 4 monomethylation (H3K4me1) and H3 lysine 9 monomethylation (H3K9me1): distribution and their association in regulating gene expression under hyperglycaemic/hyperinsulinemic conditions in 3T3 cells.
  6. Data show that H3 acetylation by Myst4 is important for neural, craniofacial, and skeletal morphogenesis, mainly through its ability to specifically regulating the MAPK signaling pathway.
    Title: Disruption of the histone acetyltransferase MYST4 leads to a Noonan syndrome-like phenotype and hyperactivated MAPK signaling in humans and mice.
  7. Deregulation of polyamine biosynthesis alters intrinsic histone acetyltransferase and deacetylase activities in murine skin and tumors.
    Title: Deregulation of polyamine biosynthesis alters intrinsic histone acetyltransferase and deacetylase activities in murine skin and tumors.
  8. MORF4 has a role in cellular aging, and MRG15 associates with both histone deacetylases and histone acetyl transferase complexes [review]
    Title: The role of the MORF/MRG family of genes in cell growth, differentiation, DNA repair, and thereby aging.
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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1)  1 citation
  • Targeted (1) 
  • Chemically induced (ENU) (1) 
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone H3 acetyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone H3K14 acetyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables histone acetyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables histone acetyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables peptide-lysine-N-acetyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
  
enables transcription coactivator activity ISO
Inferred from Sequence Orthology
more info
  
enables transcription coregulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cellular response to leukemia inhibitory factor IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within chromatin organization IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in nucleosome assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of developmental process NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of hemopoiesis NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of MOZ/MORF histone acetyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of MOZ/MORF histone acetyltransferase complex ISO
Inferred from Sequence Orthology
more info
  
part_of chromatin IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of nucleosome IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
histone acetyltransferase KAT6B
Names
MOZ, YBF2/SAS3, SAS2 and TIP60 protein 4
MYST histone acetyltransferase monocytic leukemia 4
histone acetyltransferase MYST4
histone acetyltransferase querkopf
monocytic leukemia
protein querkopf
NP_001192170.1
NP_001395624.1
NP_001395625.1
NP_059507.2
XP_006519326.1
XP_006519327.1
XP_006519328.1
XP_006519332.1
XP_017171571.1
XP_017171573.1
XP_030103747.1
XP_030103748.1
XP_036014649.1
XP_036014650.1
XP_036014651.1
XP_036014652.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001205241.2 → NP_001192170.1  histone acetyltransferase KAT6B isoform 1

    See identical proteins and their annotated locations for NP_001192170.1

    Status: VALIDATED

    Source sequence(s)
    AC115122, AC148978
    Consensus CDS
    CCDS59615.1
    UniProtKB/TrEMBL
    Q3UH94
    Related
    ENSMUSP00000138511.2, ENSMUST00000182855.8
    Conserved Domains (4) summary
    smart00526
    Location:94 → 168
    H15; Domain in histone families 1 and 5
    PLN00104
    Location:430 → 698
    PLN00104; MYST -like histone acetyltransferase; Provisional
    cd15527
    Location:272 → 318
    PHD2_KAT6A_6B; PHD finger 2 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
    cd15689
    Location:213 → 271
    PHD1_MORF; PHD finger 1 found in monocytic leukemia zinc finger protein-related factor (MORF)

  2. NM_001408695.1 → NP_001395624.1  histone acetyltransferase KAT6B isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC115122, AC148978

  3. NM_001408696.1 → NP_001395625.1  histone acetyltransferase KAT6B isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC115122, AC148978
    UniProtKB/Swiss-Prot
    E9QK86, Q7TNW5, Q8BG35, Q8BRB7, Q8C441, Q9JKX5
    Related
    ENSMUSP00000138421.2, ENSMUST00000182964.3

  4. NM_017479.4 → NP_059507.2  histone acetyltransferase KAT6B isoform 1

    See identical proteins and their annotated locations for NP_059507.2

    Status: VALIDATED

    Source sequence(s)
    AC115122, AC148978
    Consensus CDS
    CCDS59615.1
    UniProtKB/TrEMBL
    Q3UH94
    Related
    ENSMUSP00000138377.2, ENSMUST00000182405.9
    Conserved Domains (4) summary
    smart00526
    Location:94 → 168
    H15; Domain in histone families 1 and 5
    PLN00104
    Location:430 → 698
    PLN00104; MYST -like histone acetyltransferase; Provisional
    cd15527
    Location:272 → 318
    PHD2_KAT6A_6B; PHD finger 2 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
    cd15689
    Location:213 → 271
    PHD1_MORF; PHD finger 1 found in monocytic leukemia zinc finger protein-related factor (MORF)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    21549284..21722546
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006519265.5 → XP_006519328.1  histone acetyltransferase KAT6B isoform X1

    See identical proteins and their annotated locations for XP_006519328.1

    UniProtKB/TrEMBL
    A0A5F8MQ39, Q3UH94
    Conserved Domains (4) summary
    smart00526
    Location:94 → 168
    H15; Domain in histone families 1 and 5
    PLN00104
    Location:721 → 989
    PLN00104; MYST -like histone acetyltransferase; Provisional
    cd15527
    Location:272 → 318
    PHD2_KAT6A_6B; PHD finger 2 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
    cd15618
    Location:213 → 270
    PHD1_MOZ_MORF; PHD finger 1 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)

  2. XM_036158758.1 → XP_036014651.1  histone acetyltransferase KAT6B isoform X6

    UniProtKB/TrEMBL
    Q3UH94
    Conserved Domains (4) summary
    smart00526
    Location:94 → 168
    H15; Domain in histone families 1 and 5
    PLN00104
    Location:430 → 698
    PLN00104; MYST -like histone acetyltransferase; Provisional
    cd15527
    Location:272 → 318
    PHD2_KAT6A_6B; PHD finger 2 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
    cd15689
    Location:213 → 271
    PHD1_MORF; PHD finger 1 found in monocytic leukemia zinc finger protein-related factor (MORF)

  3. XM_006519264.5 → XP_006519327.1  histone acetyltransferase KAT6B isoform X1

    See identical proteins and their annotated locations for XP_006519327.1

    UniProtKB/TrEMBL
    A0A5F8MQ39, Q3UH94
    Conserved Domains (4) summary
    smart00526
    Location:94 → 168
    H15; Domain in histone families 1 and 5
    PLN00104
    Location:721 → 989
    PLN00104; MYST -like histone acetyltransferase; Provisional
    cd15527
    Location:272 → 318
    PHD2_KAT6A_6B; PHD finger 2 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
    cd15618
    Location:213 → 270
    PHD1_MOZ_MORF; PHD finger 1 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)

  4. XM_036158756.1 → XP_036014649.1  histone acetyltransferase KAT6B isoform X1

    UniProtKB/TrEMBL
    A0A5F8MQ39, Q3UH94
    Related
    ENSMUSP00000159058.2, ENSMUST00000238837.2
    Conserved Domains (4) summary
    smart00526
    Location:94 → 168
    H15; Domain in histone families 1 and 5
    PLN00104
    Location:721 → 989
    PLN00104; MYST -like histone acetyltransferase; Provisional
    cd15527
    Location:272 → 318
    PHD2_KAT6A_6B; PHD finger 2 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
    cd15618
    Location:213 → 270
    PHD1_MOZ_MORF; PHD finger 1 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)

  5. XM_036158759.1 → XP_036014652.1  histone acetyltransferase KAT6B isoform X7

    UniProtKB/TrEMBL
    Q3UH94
    Conserved Domains (4) summary
    smart00526
    Location:94 → 168
    H15; Domain in histone families 1 and 5
    PLN00104
    Location:367 → 635
    PLN00104; MYST -like histone acetyltransferase; Provisional
    cd15527
    Location:272 → 310
    PHD2_KAT6A_6B; PHD finger 2 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
    cd15689
    Location:213 → 271
    PHD1_MORF; PHD finger 1 found in monocytic leukemia zinc finger protein-related factor (MORF)

  6. XM_030247887.2 → XP_030103747.1  histone acetyltransferase KAT6B isoform X1

    UniProtKB/TrEMBL
    A0A5F8MQ39, Q3UH94
    Conserved Domains (4) summary
    smart00526
    Location:94 → 168
    H15; Domain in histone families 1 and 5
    PLN00104
    Location:721 → 989
    PLN00104; MYST -like histone acetyltransferase; Provisional
    cd15527
    Location:272 → 318
    PHD2_KAT6A_6B; PHD finger 2 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
    cd15618
    Location:213 → 270
    PHD1_MOZ_MORF; PHD finger 1 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)

  7. XM_017316082.3 → XP_017171571.1  histone acetyltransferase KAT6B isoform X2

    UniProtKB/TrEMBL
    Q3UH94
    Conserved Domains (4) summary
    smart00526
    Location:94 → 168
    H15; Domain in histone families 1 and 5
    PLN00104
    Location:721 → 989
    PLN00104; MYST -like histone acetyltransferase; Provisional
    cd15527
    Location:272 → 318
    PHD2_KAT6A_6B; PHD finger 2 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
    cd15618
    Location:213 → 270
    PHD1_MOZ_MORF; PHD finger 1 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)

  8. XM_006519263.5 → XP_006519326.1  histone acetyltransferase KAT6B isoform X1

    See identical proteins and their annotated locations for XP_006519326.1

    UniProtKB/TrEMBL
    A0A5F8MQ39, Q3UH94
    Conserved Domains (4) summary
    smart00526
    Location:94 → 168
    H15; Domain in histone families 1 and 5
    PLN00104
    Location:721 → 989
    PLN00104; MYST -like histone acetyltransferase; Provisional
    cd15527
    Location:272 → 318
    PHD2_KAT6A_6B; PHD finger 2 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
    cd15618
    Location:213 → 270
    PHD1_MOZ_MORF; PHD finger 1 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)

  9. XM_036158757.1 → XP_036014650.1  histone acetyltransferase KAT6B isoform X3

    UniProtKB/TrEMBL
    Q3UH94
    Conserved Domains (4) summary
    smart00526
    Location:94 → 168
    H15; Domain in histone families 1 and 5
    PLN00104
    Location:584 → 852
    PLN00104; MYST -like histone acetyltransferase; Provisional
    cd15527
    Location:272 → 318
    PHD2_KAT6A_6B; PHD finger 2 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
    cd15618
    Location:213 → 270
    PHD1_MOZ_MORF; PHD finger 1 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)

  10. XM_017316084.3 → XP_017171573.1  histone acetyltransferase KAT6B isoform X7

    UniProtKB/TrEMBL
    Q3UH94
    Conserved Domains (4) summary
    smart00526
    Location:94 → 168
    H15; Domain in histone families 1 and 5
    PLN00104
    Location:367 → 635
    PLN00104; MYST -like histone acetyltransferase; Provisional
    cd15527
    Location:272 → 310
    PHD2_KAT6A_6B; PHD finger 2 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
    cd15689
    Location:213 → 271
    PHD1_MORF; PHD finger 1 found in monocytic leukemia zinc finger protein-related factor (MORF)

  11. XM_006519269.5 → XP_006519332.1  histone acetyltransferase KAT6B isoform X5

    UniProtKB/TrEMBL
    Q3UH94
    Conserved Domains (2) summary
    PLN00104
    Location:436 → 704
    PLN00104; MYST -like histone acetyltransferase; Provisional
    cd15527
    Location:1 → 33
    PHD2_KAT6A_6B; PHD finger 2 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)

  12. XM_030247888.2 → XP_030103748.1  histone acetyltransferase KAT6B isoform X8

    Conserved Domains (1) summary
    PLN00104
    Location:5 → 57
    PLN00104; MYST -like histone acetyltransferase; Provisional
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BRB7.3 GenPept UniProtKB/Swiss-Prot:Q8BRB7

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