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Copg2 coatomer protein complex, subunit gamma 2 [ Mus musculus (house mouse) ]

Gene ID: 54160, updated on 5-Mar-2024

Summary

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Official Symbol
Copg2provided by MGI
Official Full Name
coatomer protein complex, subunit gamma 2provided by MGI
Primary source
MGI:MGI:1858683
See related
Ensembl:ENSMUSG00000025607 AllianceGenome:MGI:1858683
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
gamma-2-COP
Summary
Predicted to enable structural molecule activity. Predicted to be involved in Golgi vesicle transport; organelle transport along microtubule; and protein secretion. Predicted to act upstream of or within protein transport. Located in COPI-coated vesicle; Golgi membrane; and growth cone. Is expressed in brain and early conceptus. Orthologous to human COPG2 (COPI coat complex subunit gamma 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in limb E14.5 (RPKM 91.4), CNS E11.5 (RPKM 47.5) and 15 other tissues See more
Orthologs
human all
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Genomic context

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Location:
6 A3.3; 6 12.54 cM
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (30747552..30873712, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (30747554..30896815, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene centrosomal protein 41 Neighboring gene predicted gene 13782 Neighboring gene STARR-positive B cell enhancer mm9_chr6:30643637-30643938 Neighboring gene STARR-seq mESC enhancer starr_15474 Neighboring gene mesoderm specific transcript Neighboring gene microRNA 335 Neighboring gene coatomer protein complex, subunit gamma 2, opposite strand 2 Neighboring gene RIKEN cDNA 4930412F09 gene Neighboring gene predicted gene, 38781 Neighboring gene testis specific gene A13 Neighboring gene Kruppel-like transcription factor 14

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Allele-specific methylation at the promoter-associated CpG island of mouse Copg2. Yun J, et al. Mamm Genome, 2003 Jun. PMID 12879359
  2. Phylogenetic relationships of the seven coat protein subunits of the coatomer complex, and comparative sequence analysis of murine xenin and proxenin. Chow VT, et al. Biochem Genet, 2001 Jun. PMID 11530856
  3. The COPI vesicle complex binds and moves with survival motor neuron within axons. Peter CJ, et al. Hum Mol Genet, 2011 May 1. PMID 21300694, Free PMC Article
  4. Mit1/Lb9 and Copg2, new members of mouse imprinted genes closely linked to Peg1/Mest(1). Lee YJ, et al. FEBS Lett, 2000 Apr 28. PMID 10788617
  5. Overlapping Role of SCYL1 and SCYL3 in Maintaining Motor Neuron Viability. Kuliyev E, et al. J Neurosci, 2018 Mar 7. PMID 29437892, Free PMC Article

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Copg2 gene, closely linked to Mest/Peg1 gene on chr 6, is paternally imprinted.
    Title: Mit1/Lb9 and Copg2, new members of mouse imprinted genes closely linked to Peg1/Mest(1).
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables structural molecule activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intra-Golgi vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intra-Golgi vesicle-mediated transport ISO
Inferred from Sequence Orthology
more info
  
involved_in intracellular protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in organelle transport along microtubule IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein secretion IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
  
involved_in vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of COPI vesicle coat IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of COPI vesicle coat ISO
Inferred from Sequence Orthology
more info
  
located_in COPI-coated vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
is_active_in Golgi membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in endoplasmic reticulum-Golgi intermediate compartment IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in growth cone IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
part_of membrane coat IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
coatomer subunit gamma-2
Names
gamma-2-coat protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001411182.1 → NP_001398111.1  coatomer subunit gamma-2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC183098, AEKQ02054615
    Related
    ENSMUSP00000126726.4, ENSMUST00000166192.7

  2. NM_001411184.1 → NP_001398113.1  coatomer subunit gamma-2 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC183098
    Related
    ENSMUST00000131256.8

  3. NM_017478.4 → NP_059506.1  coatomer subunit gamma-2 isoform 1

    See identical proteins and their annotated locations for NP_059506.1

    Status: VALIDATED

    Source sequence(s)
    AC183098, AEKQ02054615
    Consensus CDS
    CCDS85027.1
    UniProtKB/Swiss-Prot
    A6H6J5, Q3TQD5, Q3UEL6, Q8C2J6, Q9QXK3
    Related
    ENSMUSP00000038368.7, ENSMUST00000048774.13
    Conserved Domains (5) summary
    COG5240
    Location:7 → 866
    SEC21; Vesicle coat complex COPI, gamma subunit [Intracellular trafficking and secretion]
    pfam08752
    Location:613 → 756
    COP-gamma_platf; Coatomer gamma subunit appendage platform subdomain
    pfam11701
    Location:325 → 497
    UNC45-central; Myosin-binding striated muscle assembly central
    pfam16381
    Location:758 → 870
    Coatomer_g_Cpla; Coatomer subunit gamma-1 C-terminal appendage platform
    sd00044
    Location:398 → 423
    HEAT; HEAT repeat [structural motif]

RNA

  1. NR_149738.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC183098, AEKQ02054615

  2. NR_177193.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC183098, AEKQ02054615

  3. NR_177194.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC183098, AEKQ02054615

  4. NR_183248.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC183098, AEKQ02054615

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    30747552..30873712 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036166293.1 → XP_036022186.1  coatomer subunit gamma-2 isoform X1

    Conserved Domains (2) summary
    COG5240
    Location:56 → 903
    SEC21; Vesicle coat complex COPI, gamma subunit [Intracellular trafficking and secretion]
    sd00044
    Location:435 → 460
    HEAT; HEAT repeat [structural motif]

RNA

  1. XR_001785154.3 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9QXK3.1 GenPept UniProtKB/Swiss-Prot:Q9QXK3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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