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Dnal4 dynein, axonemal, light chain 4 [ Mus musculus (house mouse) ]

Gene ID: 54152, updated on 21-Apr-2024

Summary

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Official Symbol
Dnal4provided by MGI
Official Full Name
dynein, axonemal, light chain 4provided by MGI
Primary source
MGI:MGI:1859217
See related
Ensembl:ENSMUSG00000022420 AllianceGenome:MGI:1859217
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Dnalc4; D15Ertd424e
Summary
Predicted to enable dynein intermediate chain binding activity; dynein light intermediate chain binding activity; and identical protein binding activity. Predicted to be involved in microtubule-based process. Predicted to be located in cilium; cytoplasm; and microtubule. Predicted to be part of dynein complex. Is expressed in central nervous system; heart ventricle; and retina. Human ortholog(s) of this gene implicated in congenital mirror movement disorder. Orthologous to human DNAL4 (dynein axonemal light chain 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 61.0), whole brain E14.5 (RPKM 24.4) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
15 E1; 15 37.85 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (79645654..79658649, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (79761449..79774467, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene Sad1 and UNC84 domain containing 2 Neighboring gene STARR-positive B cell enhancer ABC_E7390 Neighboring gene predicted gene 16576 Neighboring gene STARR-positive B cell enhancer ABC_E390 Neighboring gene predicted gene, 30977 Neighboring gene predicted gene, 57816 Neighboring gene neuronal pentraxin receptor Neighboring gene neuronal pentraxin chromo domain

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  2. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article
  3. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249
  4. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article
  5. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (1) 

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in microtubule-based process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in cilium IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
part_of dynein complex IEA
Inferred from Electronic Annotation
more info
  
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
dynein axonemal light chain 4
Names
dynein light chain 4, axonemal
dynein, axon, light chain 4
outer arm dynein light chain 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001411918.1 → NP_001398847.1  dynein axonemal light chain 4 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC118227
    UniProtKB/Swiss-Prot
    O54793, Q3V233, Q99K65, Q9DCM4
    Related
    ENSMUSP00000154848.2, ENSMUST00000162713.9

  2. NM_001411919.1 → NP_001398848.1  dynein axonemal light chain 4 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC118227
    UniProtKB/TrEMBL
    A0A2R8VI05
    Related
    ENSMUSP00000155613.2, ENSMUST00000229644.2

  3. NM_017470.3 → NP_059498.2  dynein axonemal light chain 4 isoform 1

    See identical proteins and their annotated locations for NP_059498.2

    Status: VALIDATED

    Source sequence(s)
    AC118227
    Consensus CDS
    CCDS27650.1
    UniProtKB/Swiss-Prot
    O54793, Q3V233, Q99K65, Q9DCM4
    Related
    ENSMUSP00000023055.7, ENSMUST00000023055.8
    Conserved Domains (1) summary
    cd21453
    Location:21 → 103
    DLC-like_DNAL4; dynein light chain (DLC)-like domain found in axonemal dynein light chain 4 (DNAL4) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    79645654..79658649 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9DCM4.2 GenPept UniProtKB/Swiss-Prot:Q9DCM4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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