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Zftraf1 zinc finger TRAF type containing 1 [ Mus musculus (house mouse) ]

Gene ID: 54151, updated on 5-Mar-2024

Summary

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Official Symbol
Zftraf1provided by MGI
Official Full Name
zinc finger TRAF type containing 1provided by MGI
Primary source
MGI:MGI:1859320
See related
Ensembl:ENSMUSG00000053929 AllianceGenome:MGI:1859320
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Chrp; Cyhr1; 1110031M01Rik
Summary
Predicted to enable zinc ion binding activity. Located in cytoplasm and nuclear envelope. Orthologous to human CYHR1 (cysteine and histidine rich 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 18.7), ovary adult (RPKM 16.0) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
15 D3; 15 36.2 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (76527586..76541120, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (76643395..76660208, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene vacuolar protein sorting 28 Neighboring gene tonsoku-like, DNA repair protein Neighboring gene STARR-positive B cell enhancer ABC_E1481 Neighboring gene predicted gene, 57852 Neighboring gene STARR-positive B cell enhancer ABC_E760 Neighboring gene STARR-positive B cell enhancer ABC_E9419 Neighboring gene STARR-positive B cell enhancer ABC_E3145 Neighboring gene transmembrane protein 276 Neighboring gene kinesin family member C2 Neighboring gene forkhead box H1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Regulation of anxiety-like behavior and Crhr1 expression in the basolateral amygdala by LMO3. Savarese A, et al. Psychoneuroendocrinology, 2018 Jun. PMID 29609111, Free PMC Article
  2. Interaction of a novel cysteine and histidine-rich cytoplasmic protein with galectin-3 in a carbohydrate-independent manner. Menon RP, et al. FEBS Lett, 2000 Mar 31. PMID 10745073
  3. Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Aug 31. PMID 14621295
  4. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249
  5. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Readthrough Gm57852

Readthrough gene: Gm57852, Included gene: Tmem276

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nuclear envelope IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger TRAF-type-containing protein 1
Names
Zinc finger TRAF-type-containing protein 1
cysteine and histidine rich 1
cysteine and histidine-rich cytoplasmic protein
cysteine and histidine-rich protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001276321.2 → NP_001263250.1  zinc finger TRAF-type-containing protein 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC156550
    Consensus CDS
    CCDS70643.1
    UniProtKB/TrEMBL
    H3BIV6
    Related
    ENSMUSP00000134739.2, ENSMUST00000176274.2
    Conserved Domains (1) summary
    cl19105
    Location:161 → 222
    Sina; Seven in absentia (Sina) protein family, C-terminal substrate binding domain; composed of the Drosophila Sina protein, the mammalian Sina homolog (Siah), the plant protein SINAT5, and similar proteins. Sina, Siah and SINAT5 are RING-containing proteins ...

  2. NM_001357882.2 → NP_001344811.1  zinc finger TRAF-type-containing protein 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC156550
    UniProtKB/Swiss-Prot
    H3BIV6, P0DW87
    Conserved Domains (2) summary
    cd16505
    Location:103 → 151
    RING-HC_CYHR1; RING finger, HC subclass, found in cysteine and histidine-rich protein 1 (CYHR1) and similar proteins
    cl19105
    Location:161 → 222
    Sina; Seven in absentia (Sina) protein family, C-terminal substrate binding domain; composed of the Drosophila Sina protein, the mammalian Sina homolog (Siah), the plant protein SINAT5, and similar proteins. Sina, Siah and SINAT5 are RING-containing proteins ...

  3. NM_001408103.1 → NP_001395032.1  zinc finger TRAF-type-containing protein 1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC156550

  4. NM_001408104.1 → NP_001395033.1  zinc finger TRAF-type-containing protein 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC156550

  5. NM_001408207.1 → NP_001395136.1  zinc finger TRAF-type-containing protein 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC156550

  6. NM_001408208.1 → NP_001395137.1  zinc finger TRAF-type-containing protein 1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC156550

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    76527586..76541120 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P0DW87.1 GenPept UniProtKB/Swiss-Prot:P0DW87

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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