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MIR4435-2HG MIR4435-2 host gene [ Homo sapiens (human) ]

Gene ID: 541471, updated on 8-Apr-2024

Summary

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Official Symbol
MIR4435-2HGprovided by HGNC
Official Full Name
MIR4435-2 host geneprovided by HGNC
Primary source
HGNC:HGNC:35163
See related
Ensembl:ENSG00000172965 MIM:617144; AllianceGenome:HGNC:35163
Gene type
ncRNA
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AGD2; MORRBID; LINC00978; MIR4435-1HG; lncRNA-AWPPH
Expression
Ubiquitous expression in appendix (RPKM 2.9), placenta (RPKM 2.8) and 24 other tissues See more
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Genomic context

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Location:
2q13
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (111195866..111495161, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (111618930..111920924, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (111953443..112252738, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11865 Neighboring gene Sharpr-MPRA regulatory region 8028 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11866 Neighboring gene BCL2 like 11 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:111923374-111923874 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16383 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16384 Neighboring gene uncharacterized LOC124907868 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11867 Neighboring gene Sharpr-MPRA regulatory region 6991 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16385 Neighboring gene periaxin-like Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:112019862-112020362 Neighboring gene uncharacterized LOC101927283 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:112059022-112059522 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr2:112062300-112062800 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr2:112062801-112063301 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:112068229-112068736 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:112067720-112068228 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:112074438-112074970 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:112077463-112078099 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:112078100-112078735 Neighboring gene ribosomal protein S14 pseudogene 4 Neighboring gene microRNA 4435-2 Neighboring gene platelet activating factor acetylhydrolase 1b regulatory subunit 1 pseudogene 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:112193024-112193588 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:112193589-112194153 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:112211190-112211923 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:112210455-112211189 Neighboring gene uncharacterized LOC124906065 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:112244635-112245487 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr2:112252044-112253243 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:112289353-112289852 Neighboring gene uncharacterized LOC124906066 Neighboring gene NANOG hESC enhancer GRCh37_chr2:112290355-112290856 Neighboring gene serous ovarian cancer associated RNA Neighboring gene DBF4 pseudogene 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Long-chain Non-coding RNA MIR4435-2HG Expression Correlates With Size of Intestinal Polyps in Children and With Metastasis of Colon Cancer. Zhu D, et al. Anticancer Res, 2022 Oct. PMID 36191994
  2. Identification of Long Non-Coding RNA MIR4435-2HG as a Prognostic Biomarker in Bladder Cancer. Hu Z, et al. Genes (Basel), 2022 Aug 17. PMID 36011373, Free PMC Article
  3. Long Noncoding RNA MIR4435-2HG Suppresses Colorectal Cancer Initiation and Progression By Reprogramming Neutrophils. Yu H, et al. Cancer Immunol Res, 2022 Sep 1. PMID 35862232, Free PMC Article
  4. MIR4435-2HG Is a Potential Pan-Cancer Biomarker for Diagnosis and Prognosis. Zhong C, et al. Front Immunol, 2022. PMID 35784328, Free PMC Article
  5. MIR4435-2HG: A Tumor-associated Long Non-coding RNA. Zhao F, et al. Curr Pharm Des, 2022. PMID 35674305

See all (58) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. M2 Macrophage-Derived Exosomal lncRNA MIR4435-2HG Promotes Progression of Infantile Hemangiomas by Targeting HNRNPA1.
    Title: M2 Macrophage-Derived Exosomal lncRNA MIR4435-2HG Promotes Progression of Infantile Hemangiomas by Targeting HNRNPA1.
  2. LncRNA MIR4435-2HG drives cancer progression by modulating cell cycle regulators and mTOR signaling in stroma-enriched subtypes of urothelial carcinoma of the bladder.
    Title: LncRNA MIR4435-2HG drives cancer progression by modulating cell cycle regulators and mTOR signaling in stroma-enriched subtypes of urothelial carcinoma of the bladder.
  3. LINC00978 regulates metabolic rewiring to promote the malignancy of glioblastoma through AKR1B1.
    Title: LINC00978 regulates metabolic rewiring to promote the malignancy of glioblastoma through AKR1B1.
  4. Long-chain Non-coding RNA MIR4435-2HG Expression Correlates With Size of Intestinal Polyps in Children and With Metastasis of Colon Cancer.
    Title: Long-chain Non-coding RNA MIR4435-2HG Expression Correlates With Size of Intestinal Polyps in Children and With Metastasis of Colon Cancer.
  5. LncRNA AWPPH is downregulated in osteoporosis and regulates type I collagen alpha1 and alpha2 ratio.
    Title: LncRNA AWPPH is downregulated in osteoporosis and regulates type I collagen α1 and α2 ratio.
  6. MIR4435-2HG: A Tumor-associated Long Non-coding RNA.
    Title: MIR4435-2HG: A Tumor-associated Long Non-coding RNA.
  7. Long Noncoding RNA MIR4435-2HG Suppresses Colorectal Cancer Initiation and Progression By Reprogramming Neutrophils.
    Title: Long Noncoding RNA MIR4435-2HG Suppresses Colorectal Cancer Initiation and Progression By Reprogramming Neutrophils.
  8. Identification of Long Non-Coding RNA MIR4435-2HG as a Prognostic Biomarker in Bladder Cancer.
    Title: Identification of Long Non-Coding RNA MIR4435-2HG as a Prognostic Biomarker in Bladder Cancer.
  9. MIR4435-2HG Is a Potential Pan-Cancer Biomarker for Diagnosis and Prognosis.
    Title: MIR4435-2HG Is a Potential Pan-Cancer Biomarker for Diagnosis and Prognosis.
  10. Long non-coding RNA MIR4435-2HG/microRNA-125a-5p axis is involved in myocardial ischemic injuries.
    Title: Long non-coding RNA MIR4435-2HG/microRNA-125a-5p axis is involved in myocardial ischemic injuries.
Submit: New GeneRIF Correction See all GeneRIFs (52)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Other Names

  • MIR4435-1 host gene (non-protein coding)
  • adipogenesis down-regulated transcript 2
  • lncRNA associated with poor prognosis of HCC
  • long intergenic non-protein coding RNA 978
  • myeloid RNA regulator of Bim-induced death

Clone Names

  • FLJ10934, AC068491.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_015395.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC017002, AC068491, AC108463
    Related
    ENST00000666144.1

  2. NR_024373.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' end and is much shorter than variant 1.
    Source sequence(s)
    BC014776, DA316588
    Related
    ENST00000409569.2

  3. NR_136161.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC108463, BQ026171, BX647931, DA316588
    Related
    ENST00000439362.6

  4. NR_136162.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC017002, AC068491, AC096670, AC108463
    Related
    ENST00000667670.1

  5. NR_136163.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC017002, AC068491, AC096670, AC108463
    Related
    ENST00000661559.1

  6. NR_136164.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC017002, AC068491, AC096670, AC108463

  7. NR_136165.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AB485977, AC108463, DA316588
    Related
    ENST00000659458.1

  8. NR_136166.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC017002, AC068491, AC108463
    Related
    ENST00000659933.1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    111195866..111495161 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    111618930..111920924 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001013744.1: Suppressed sequence

    Description
    NM_001013744.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
Nucleotide Protein
Heading Accession and Version

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