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Acrbp proacrosin binding protein [ Mus musculus (house mouse) ]

Gene ID: 54137, updated on 5-Mar-2024

Summary

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Official Symbol
Acrbpprovided by MGI
Official Full Name
proacrosin binding proteinprovided by MGI
Primary source
MGI:MGI:1859515
See related
Ensembl:ENSMUSG00000072770 AllianceGenome:MGI:1859515
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
sp32; OY-TES-1
Summary
Predicted to enable peptidase activator activity. Involved in acrosome assembly and fertilization. Located in acrosomal vesicle. Is expressed in testis. Orthologous to human ACRBP (acrosin binding protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 288.0) and thymus adult (RPKM 11.3) See more
Orthologs
human all
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Genomic context

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See Acrbp in Genome Data Viewer
Location:
6 59.17 cM; 6 F2
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (125026890..125040228)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (125049927..125063265)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930557K07 gene Neighboring gene STARR-positive B cell enhancer ABC_E1711 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:124959611-124959720 Neighboring gene zinc finger protein 384 Neighboring gene STARR-positive B cell enhancer ABC_E1071 Neighboring gene STARR-seq mESC enhancer starr_17323 Neighboring gene STARR-positive B cell enhancer ABC_E6489 Neighboring gene inhibitor of growth family, member 4 Neighboring gene lysophosphatidic acid receptor 5 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:125039823-125040010 Neighboring gene STARR-positive B cell enhancer ABC_E4864 Neighboring gene microRNA 7045 Neighboring gene chromodomain helicase DNA binding protein 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Behavior of ACRBP-deficient mouse sperm in the female reproductive tract. Nagashima K, et al. J Reprod Dev, 2019 Apr 12. PMID 30606959, Free PMC Article
  2. Proacrosin-deficient mice and zona pellucida modifications in an experimental model of multifactorial infertility. Nayernia K, et al. Mol Hum Reprod, 2002 May. PMID 11994540
  3. Biogenesis of sperm acrosome is regulated by pre-mRNA alternative splicing of Acrbp in the mouse. Kanemori Y, et al. Proc Natl Acad Sci U S A, 2016 Jun 28. PMID 27303034, Free PMC Article
  4. Identification of proacrosin binding protein sp32 precursor as a human cancer/testis antigen. Ono T, et al. Proc Natl Acad Sci U S A, 2001 Mar 13. PMID 11248070, Free PMC Article
  5. The histone methyltransferase SETD2 is required for expression of acrosin-binding protein 1 and protamines and essential for spermiogenesis in mice. Zuo X, et al. J Biol Chem, 2018 Jun 15. PMID 29716999, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Male subfertility of ACRBP-deficient mice may be attributed to incompleteness of the acrosome reaction rather than impairment in sperm migration from the uterus to the oviduct.
    Title: Behavior of ACRBP-deficient mouse sperm in the female reproductive tract.
  2. Setd2 deficiency results in complete loss of H3K36me3 and significantly decreases expression of thousands of genes, including those encoding acrosin-binding protein 1 (Acrbp1) and protamines, required for spermatogenesis.
    Title: The histone methyltransferase SETD2 is required for expression of acrosin-binding protein 1 and protamines and essential for spermiogenesis in mice.
  3. ACRBP-null male mice showed a severely reduced fertility, because of malformation of the acrosome.
    Title: Biogenesis of sperm acrosome is regulated by pre-mRNA alternative splicing of Acrbp in the mouse.
  4. Two forms of Acrbp mRNA-wild-type Acrbp-W and variant Acrbp-V5 mRNAs-were generated by alternative splicing of Acrbp in the mouse.
    Title: Two functional forms of ACRBP/sp32 are produced by pre-mRNA alternative splicing in the mouse.
  5. Data suggest that the fertility defect in PCSK4 (proprotein convertase subtilisin/kexin type 4) knockout mice is due, in part, to altered processing/proteolysis of ACRBP as well as structural abnormalities in sperm heads and acrosomes.
    Title: Alteration in the processing of the ACRBP/sp32 protein and sperm head/acrosome malformations in proprotein convertase 4 (PCSK4) null mice.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Clone Names

  • MGC74248

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables peptidase activator activity ISA
Inferred from Sequence Alignment
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in acrosome assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in fertilization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in spermatid development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within spermatid development ISA
Inferred from Sequence Alignment
more info
 PubMed 
Component Evidence Code Pubs
is_active_in acrosomal vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in acrosomal vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in acrosomal vesicle ISA
Inferred from Sequence Alignment
more info
 PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
acrosin-binding protein
Names
acrosin-binding protein, 60 kDa form

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001127340.1 → NP_001120812.1  acrosin-binding protein isoform 2 precursor

    See identical proteins and their annotated locations for NP_001120812.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' coding region and 3' UTR, compared to variant 1, resulting in a protein (isoform 2) with a shorter, distinct C-terminus when compared to isoform 1.
    Source sequence(s)
    AV260707, BM938496, BY099028
    Consensus CDS
    CCDS51910.1
    UniProtKB/Swiss-Prot
    Q3V140
    Related
    ENSMUSP00000108033.2, ENSMUST00000112414.8
    Conserved Domains (1) summary
    pfam07222
    Location:1 → 238
    PBP_sp32; Proacrosin binding protein sp32

  2. NM_016845.2 → NP_058541.2  acrosin-binding protein isoform 1 precursor

    See identical proteins and their annotated locations for NP_058541.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK132705, BY099028
    Consensus CDS
    CCDS20542.1
    UniProtKB/Swiss-Prot
    Q3V140, Q62253, Q62254, Q8C621, Q91VQ1
    Related
    ENSMUSP00000085632.6, ENSMUST00000088294.12
    Conserved Domains (1) summary
    pfam07222
    Location:1 → 238
    PBP_sp32; Proacrosin binding protein sp32

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    125026890..125040228
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3V140.1 GenPept UniProtKB/Swiss-Prot:Q3V140

Gene LinkOut

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