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Actr1a ARP1 actin-related protein 1A, centractin alpha [ Mus musculus (house mouse) ]

Gene ID: 54130, updated on 11-Apr-2024

Summary

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Official Symbol
Actr1aprovided by MGI
Official Full Name
ARP1 actin-related protein 1A, centractin alphaprovided by MGI
Primary source
MGI:MGI:1858964
See related
Ensembl:ENSMUSG00000025228 AllianceGenome:MGI:1858964
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Arp1; actin-RPV; alpha-Arp1
Summary
Predicted to enable ATP binding activity. Located in myelin sheath. Is expressed in ganglia and trigeminal nerve. Orthologous to human ACTR1A (actin related protein 1A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 78.3), CNS E18 (RPKM 74.5) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
19 C3; 19 38.84 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (46365252..46384180, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (46376813..46395741, complement)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 2310034G01 gene Neighboring gene major facilitator superfamily domain containing 13a Neighboring gene predicted gene, 24610 Neighboring gene STARR-positive B cell enhancer ABC_E3253 Neighboring gene STARR-positive B cell enhancer ABC_E7668 Neighboring gene STARR-positive B cell enhancer ABC_E1528 Neighboring gene SUFU negative regulator of hedgehog signaling Neighboring gene STARR-positive B cell enhancer ABC_E4288 Neighboring gene STARR-positive B cell enhancer ABC_E5708 Neighboring gene STARR-seq mESC enhancer starr_46309 Neighboring gene STARR-positive B cell enhancer ABC_E268 Neighboring gene STARR-seq mESC enhancer starr_46312 Neighboring gene tripartite motif-containing 8

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Primary structure of mouse actin-related protein 1 (Arp1) and its tissue expression. Kusano K, et al. Zoolog Sci, 1997 Feb. PMID 9200982
  2. Beta-III spectrin mutation L253P associated with spinocerebellar ataxia type 5 interferes with binding to Arp1 and protein trafficking from the Golgi. Clarkson YL, et al. Hum Mol Genet, 2010 Sep 15. PMID 20603325, Free PMC Article
  3. Src homology 2 (SH2)-containing 5'-inositol phosphatase localizes to podosomes, and the SH2 domain is implicated in the attenuation of bone resorption in osteoclasts. Yogo K, et al. Endocrinology, 2006 Jul. PMID 16601135
  4. Ecm29-mediated proteasomal distribution modulates excitatory GABA responses in the developing brain. Lee M, et al. J Cell Biol, 2020 Feb 3. PMID 31910261, Free PMC Article
  5. Interactions between the evolutionarily conserved, actin-related protein, Arp11, actin, and Arp1. Eckley DM, et al. Mol Biol Cell, 2003 Jul. PMID 12857853, Free PMC Article

See all (40) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Beta-III spectrin mutation L253P interferes with binding to Arp1 and protein trafficking from the Golgi.
    Title: Beta-III spectrin mutation L253P associated with spinocerebellar ataxia type 5 interferes with binding to Arp1 and protein trafficking from the Golgi.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in COPI-coated vesicle ISO
Inferred from Sequence Orthology
more info
  
located_in cell cortex ISO
Inferred from Sequence Orthology
more info
  
located_in centriole ISO
Inferred from Sequence Orthology
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
part_of dynactin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in manchette ISO
Inferred from Sequence Orthology
more info
  
located_in microtubule cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
located_in myelin sheath HDA PubMed 

General protein information

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Preferred Names
alpha-centractin
Names
ARP1 actin-related protein 1 homolog A, centractin alpha
actin-related protein 1 alpha
centrosome-associated actin homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001365070.1 → NP_001351999.1  alpha-centractin isoform 2

    Status: VALIDATED

    Source sequence(s)
    AK019518, BY794369, CD776146
    Consensus CDS
    CCDS89411.1
    UniProtKB/TrEMBL
    A0A494BB86
    Related
    ENSMUSP00000158413.2, ENSMUST00000237742.2
    Conserved Domains (1) summary
    cl17037
    Location:5 → 307
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

  2. NM_016860.2 → NP_058556.1  alpha-centractin isoform 1

    See identical proteins and their annotated locations for NP_058556.1

    Status: VALIDATED

    Source sequence(s)
    AB010297, BY794369, CD776146
    Consensus CDS
    CCDS29878.1
    UniProtKB/Swiss-Prot
    P61164, Q3TJF9
    Related
    ENSMUSP00000039844.5, ENSMUST00000040270.6
    Conserved Domains (1) summary
    cl17037
    Location:5 → 376
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    46365252..46384180 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P61164.1 GenPept UniProtKB/Swiss-Prot:P61164

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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