CHRAC1 chromatin accessibility complex subunit 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: CHRAC1provided by HGNC
Official Full Name: chromatin accessibility complex subunit 1provided by HGNC
Primary source: HGNC:HGNC:13544
See related: Ensembl:ENSG00000104472 MIM:607268; AllianceGenome:HGNC:13544
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: YCL1; CHARC1; CHARC15; CHRAC-1; CHRAC15; CHRAC-15
Summary: CHRAC1 is a histone-fold protein that interacts with other histone-fold proteins to bind DNA in a sequence-independent manner. These histone-fold protein dimers combine within larger enzymatic complexes for DNA transcription, replication, and packaging.[supplied by OMIM, Apr 2004]
Expression: Ubiquitous expression in thyroid (RPKM 10.5), lymph node (RPKM 9.8) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 8q24.3

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	8	NC_000008.11 (140511322..140517154)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	8	NC_060932.1 (141631678..141637508)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	8	NC_000008.10 (141521421..141527253)

Chromosome 8 - NC_000008.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Chromatin accessibility complex subunit 1 enhances tumor growth by regulating the oncogenic transcription of YAP in breast and cervical cancer.
Title: Chromatin accessibility complex subunit 1 enhances tumor growth by regulating the oncogenic transcription of YAP in breast and cervical cancer.
CHRAC1 promotes human lung cancer growth through regulating YAP transcriptional activity.
Title: CHRAC1 promotes human lung cancer growth through regulating YAP transcriptional activity.
-RAD21 and EIF3H, both on chromosome 8q23, CHRAC1 on chromosome 8q24.3 and TANC2 on chromosome 17q23-were confirmed to be driver genes regulating the proliferation/survival of clonogenic breast cancer cells
Title: A siRNA screen identifies RAD21, EIF3H, CHRAC1 and TANC2 as driver genes within the 8q23, 8q24.3 and 17q23 amplicons in breast cancer with effects on cell growth, survival and transformation.

Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH68212 (e-PCR)
- UniSTS:70145

D16S325 (e-PCR)
- UniSTS:147089

SGC31771 (e-PCR)
- UniSTS:1782

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables DNA binding	NAS Non-traceable Author Statement more info	PubMed
enables DNA-directed DNA polymerase activity	NAS Non-traceable Author Statement more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein heterodimerization activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in DNA biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in DNA-templated DNA replication	IBA Inferred from Biological aspect of Ancestor more info
involved_in chromatin remodeling	IBA Inferred from Biological aspect of Ancestor more info
involved_in chromatin remodeling	IDA Inferred from Direct Assay more info	PubMed
involved_in chromatin remodeling	NAS Non-traceable Author Statement more info	PubMed
involved_in nucleosome assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of DNA replication	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of CHRAC	IBA Inferred from Biological aspect of Ancestor more info
part_of CHRAC	NAS Non-traceable Author Statement more info	PubMed
part_of epsilon DNA polymerase complex	NAS Non-traceable Author Statement more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
part_of pericentric heterochromatin	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: chromatin accessibility complex protein 1

Names: DNA polymerase epsilon subunit p15; chromatin accessibility complex 1; chromatin accessibility complex 15 kDa protein; histone-fold protein CHRAC15

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_017444.6 → NP_059140.1 chromatin accessibility complex protein 1

See identical proteins and their annotated locations for NP_059140.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the functional protein.

Source sequence(s)

AC107375, AK023537

Consensus CDS

CCDS6379.1

UniProtKB/Swiss-Prot

Q9NRG0

Related

ENSP00000220913.5, ENST00000220913.10

Conserved Domains (1) summary

cl28542
Location:15 → 97

BUR6; Class 2 transcription repressor NC2, alpha subunit (DRAP1 homolog) [Transcription]

RNA

NR_023360.3 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (2) omits a coding exon resulting in a frameshift and truncation of the open reading frame. The predicted protein would be only 56 amino acids in length. It is not known if a protein is actually encoded from this transcript.

Source sequence(s)

AC107375, AK308709, DA647606
NR_040712.2 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (3) uses an alternate 5' exon, compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the coding region, including the translational start codon, found in variant 1.

Source sequence(s)

AC107375, BU160855