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Nell2 NEL-like 2 [ Mus musculus (house mouse) ]

Gene ID: 54003, updated on 21-Apr-2024

Summary

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Official Symbol
Nell2provided by MGI
Official Full Name
NEL-like 2provided by MGI
Primary source
MGI:MGI:1858510
See related
Ensembl:ENSMUSG00000022454 AllianceGenome:MGI:1858510
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mel91; A330108N19Rik
Summary
Predicted to enable heparin binding activity; identical protein binding activity; and protein kinase C binding activity. Predicted to be involved in several processes, including development of secondary female sexual characteristics; neuron cellular homeostasis; and positive regulation of hormone secretion. Predicted to be located in several cellular components, including dendrite; extracellular space; and perikaryon. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; axial skeleton; central nervous system; limb mesenchyme; and sensory organ. Orthologous to human NELL2 (neural EGFL like 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cortex adult (RPKM 60.0), frontal lobe adult (RPKM 49.2) and 7 other tissues See more
Orthologs
human all
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Genomic context

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Location:
15 E3; 15 49.39 cM
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (95117321..95426677, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (95219440..95528796, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100043315 Neighboring gene STARR-seq mESC enhancer starr_39563 Neighboring gene predicted gene, 31075 Neighboring gene STARR-seq mESC enhancer starr_39564 Neighboring gene predicted gene, 31370 Neighboring gene STARR-seq mESC enhancer starr_39565 Neighboring gene STARR-seq mESC enhancer starr_39566 Neighboring gene STARR-seq mESC enhancer starr_39567 Neighboring gene STARR-seq mESC enhancer starr_39568 Neighboring gene predicted gene, 31551 Neighboring gene predicted gene, 24668

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Estrogen-dependent transcription of the NEL-like 2 (NELL2) gene and its role in protection from cell death. Choi EJ, et al. J Biol Chem, 2010 Aug 6. PMID 20538601, Free PMC Article
  2. Spatial learning of mice lacking a neuron-specific epidermal growth factor family protein, NELL2. Matsuyama S, et al. J Pharmacol Sci, 2005 Jul. PMID 15988128
  3. Enhanced long-term potentiation in vivo in dentate gyrus of NELL2-deficient mice. Matsuyama S, et al. Neuroreport, 2004 Mar 1. PMID 15094495
  4. NELL2-Robo3 complex structure reveals mechanisms of receptor activation for axon guidance. Pak JS, et al. Nat Commun, 2020 Mar 20. PMID 32198364, Free PMC Article
  5. The cytosolic splicing variant of NELL2 inhibits PKCβ1 in glial cells. Lee da Y, et al. Biochem Biophys Res Commun, 2014 Nov 21. PMID 25450684

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Male mice in which Nell2 had been knocked out were infertile.
    Title: NELL2-mediated lumicrine signaling through OVCH2 is required for male fertility.
  2. Nell2 acts as a domain-specific positional label in the dorsal lateral geniculate nucleus that discriminates contralateral and ipsilateral retinal ganglion cell axons, and it plays essential roles in the establishment of the eye-specific retinogeniculate projection
    Title: Nell2 regulates the contralateral-versus-ipsilateral visual projection as a domain-specific positional cue.
  3. Cytosolic NELL2 specifically interacts with PKC beta isotypes and inhibits PKC beta1 through direct binding to the N-terminal pseudosubstrate domain of PKC beta1.
    Title: The cytosolic splicing variant of NELL2 inhibits PKCβ1 in glial cells.
  4. These findings identify NELL2 as an axon guidance cue and establish Robo3 as a multifunctional regulator of pathfinding that simultaneously mediates NELL2 repulsion, inhibits Slit repulsion, and facilitates Netrin attraction to achieve a common guidance purpose.
    Title: Operational redundancy in axon guidance through the multifunctional receptor Robo3 and its ligand NELL2.
  5. NELL2 plays an important role in the regulation of neuronal differentiation via control of N-cadherin expression and cell aggregation.
    Title: Neural epidermal growth factor-like like protein 2 (NELL2) promotes aggregation of embryonic carcinoma P19 cells by inducing N-cadherin expression.
  6. Nel interacts with a range of molecules through its different domains and exerts distinct functions.
    Title: Structure-function analysis of Nel, a thrombospondin-1-like glycoprotein involved in neural development and functions.
  7. the NELL2 gene is trans-activated by E2 and contributes to mediating the survival promoting effects of E2 via intracellular signaling pathway of ERK
    Title: Estrogen-dependent transcription of the NEL-like 2 (NELL2) gene and its role in protection from cell death.
  8. NELL2 plays an important role as a novel suppressor in long-term potentiation in vivo in the mouse dentate gyrus
    Title: Enhanced long-term potentiation in vivo in dentate gyrus of NELL2-deficient mice.
  9. NELL2 plays an important role in hippocampus-dependent spatial learning and that emotional learning does not depend critically on NELL2.
    Title: Spatial learning of mice lacking a neuron-specific epidermal growth factor family protein, NELL2.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium ion binding ISO
Inferred from Sequence Orthology
more info
  
enables heparin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables heparin binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase C binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein kinase C binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in commissural neuron axon guidance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in commissural neuron axon guidance ISO
Inferred from Sequence Orthology
more info
  
involved_in development of secondary female sexual characteristics ISO
Inferred from Sequence Orthology
more info
  
involved_in fertilization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in neurogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in neuron cellular homeostasis ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of hormone secretion ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of growth ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in dendrite ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular region IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular region TAS
Traceable Author Statement
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
  
located_in perikaryon ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
protein kinase C-binding protein NELL2
Names
NEL-like protein 2
nel-like 2 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001289653.1 → NP_001276582.1  protein kinase C-binding protein NELL2 precursor

    See identical proteins and their annotated locations for NP_001276582.1

    Status: VALIDATED

    Source sequence(s)
    AC109198, AC163991, AC164402
    Consensus CDS
    CCDS27775.1
    UniProtKB/Swiss-Prot
    Q61220, Q80UM5
    UniProtKB/TrEMBL
    A0A2R8VHV8
    Related
    ENSMUSP00000074751.3, ENSMUST00000075275.3
    Conserved Domains (5) summary
    smart00179
    Location:558 → 592
    EGF_CA; Calcium-binding EGF-like domain
    smart00210
    Location:32 → 217
    TSPN; Thrombospondin N-terminal -like domains
    pfam07645
    Location:605 → 636
    EGF_CA; Calcium-binding EGF domain
    cl17735
    Location:277 → 333
    VWC; von Willebrand factor type C domain
    pfam12947
    Location:489 → 524
    EGF_3; EGF domain

  2. NM_001356950.1 → NP_001343879.1  protein kinase C-binding protein NELL2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC109198, AC163991, AC164402
    Consensus CDS
    CCDS27775.1
    UniProtKB/Swiss-Prot
    Q61220, Q80UM5
    UniProtKB/TrEMBL
    A0A2R8VHV8
    Related
    ENSMUSP00000131665.2, ENSMUST00000166170.9
    Conserved Domains (5) summary
    smart00179
    Location:558 → 592
    EGF_CA; Calcium-binding EGF-like domain
    smart00210
    Location:32 → 217
    TSPN; Thrombospondin N-terminal -like domains
    pfam07645
    Location:605 → 636
    EGF_CA; Calcium-binding EGF domain
    cl17735
    Location:277 → 333
    VWC; von Willebrand factor type C domain
    pfam12947
    Location:489 → 524
    EGF_3; EGF domain

  3. NM_001356951.1 → NP_001343880.1  protein kinase C-binding protein NELL2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC109198, AC163991, AC164402
    Consensus CDS
    CCDS27775.1
    UniProtKB/Swiss-Prot
    Q61220, Q80UM5
    UniProtKB/TrEMBL
    A0A2R8VHV8
    Related
    ENSMUSP00000155490.2, ENSMUST00000229981.2
    Conserved Domains (5) summary
    smart00179
    Location:558 → 592
    EGF_CA; Calcium-binding EGF-like domain
    smart00210
    Location:32 → 217
    TSPN; Thrombospondin N-terminal -like domains
    pfam07645
    Location:605 → 636
    EGF_CA; Calcium-binding EGF domain
    cl17735
    Location:277 → 333
    VWC; von Willebrand factor type C domain
    pfam12947
    Location:489 → 524
    EGF_3; EGF domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    95117321..95426677 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006521163.3 → XP_006521226.1  protein kinase C-binding protein NELL2 isoform X1

    See identical proteins and their annotated locations for XP_006521226.1

    UniProtKB/Swiss-Prot
    Q61220, Q80UM5
    UniProtKB/TrEMBL
    A0A2R8VHV8
    Conserved Domains (5) summary
    smart00179
    Location:558 → 592
    EGF_CA; Calcium-binding EGF-like domain
    smart00210
    Location:32 → 217
    TSPN; Thrombospondin N-terminal -like domains
    pfam07645
    Location:605 → 636
    EGF_CA; Calcium-binding EGF domain
    cl17735
    Location:277 → 333
    VWC; von Willebrand factor type C domain
    pfam12947
    Location:489 → 524
    EGF_3; EGF domain

  2. XM_036159519.1 → XP_036015412.1  protein kinase C-binding protein NELL2 isoform X2

    UniProtKB/TrEMBL
    A0A2R8VHV8
    Conserved Domains (6) summary
    smart00179
    Location:558 → 592
    EGF_CA; Calcium-binding EGF-like domain
    smart00210
    Location:32 → 217
    TSPN; Thrombospondin N-terminal -like domains
    pfam00093
    Location:277 → 333
    VWC; von Willebrand factor type C domain
    pfam07645
    Location:605 → 636
    EGF_CA; Calcium-binding EGF domain
    cl17735
    Location:708 → 758
    VWC; von Willebrand factor type C domain
    pfam12947
    Location:489 → 524
    EGF_3; EGF domain

  3. XM_006521164.5 → XP_006521227.1  protein kinase C-binding protein NELL2 isoform X2

    UniProtKB/TrEMBL
    A0A2R8VHV8
    Related
    ENSMUSP00000155436.2, ENSMUST00000229933.2
    Conserved Domains (6) summary
    smart00179
    Location:558 → 592
    EGF_CA; Calcium-binding EGF-like domain
    smart00210
    Location:32 → 217
    TSPN; Thrombospondin N-terminal -like domains
    pfam00093
    Location:277 → 333
    VWC; von Willebrand factor type C domain
    pfam07645
    Location:605 → 636
    EGF_CA; Calcium-binding EGF domain
    cl17735
    Location:708 → 758
    VWC; von Willebrand factor type C domain
    pfam12947
    Location:489 → 524
    EGF_3; EGF domain

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_016743.2: Suppressed sequence

    Description
    NM_016743.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q61220.3 GenPept UniProtKB/Swiss-Prot:Q61220

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