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Ddx20 DEAD box helicase 20 [ Mus musculus (house mouse) ]

Gene ID: 53975, updated on 11-Apr-2024

Summary

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Official Symbol
Ddx20provided by MGI
Official Full Name
DEAD box helicase 20provided by MGI
Primary source
MGI:MGI:1858415
See related
Ensembl:ENSMUSG00000027905 AllianceGenome:MGI:1858415
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
dp103; GEMIN3
Summary
Enables histone deacetylase binding activity and protein-macromolecule adaptor activity. Involved in positive regulation of apoptotic process. Acts upstream of or within negative regulation of transcription by RNA polymerase II; oogenesis; and regulation of steroid biosynthetic process. Part of RNA polymerase II transcription repressor complex. Is expressed in several structures, including branchial arch; genitourinary system; liver; lung; and spleen. Orthologous to human DDX20 (DEAD-box helicase 20). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis adult (RPKM 40.1), ovary adult (RPKM 10.1) and 23 other tissues See more
Orthologs
human all
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Genomic context

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Location:
3 F2.2; 3 46.43 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (105585586..105595104, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (105678270..105687788, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 34837 Neighboring gene STARR-seq mESC enhancer starr_08632 Neighboring gene STARR-seq mESC enhancer starr_08634 Neighboring gene potassium voltage-gated channel, Shal-related family, member 3, opposite strand Neighboring gene potassium voltage-gated channel, Shal-related family, member 3 Neighboring gene STARR-positive B cell enhancer ABC_E6095 Neighboring gene STARR-positive B cell enhancer ABC_E8804 Neighboring gene STARR-positive B cell enhancer ABC_E2091 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:105507469-105507578 Neighboring gene inka box actin regulator 2 Neighboring gene RAS-related protein 1a Neighboring gene STARR-positive B cell enhancer ABC_E10203 Neighboring gene STARR-positive B cell enhancer ABC_E11208

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Ddx20, DEAD box helicase 20, is essential for the differentiation of oligodendrocyte and maintenance of myelin gene expression. Simankova A, et al. Glia, 2021 Nov. PMID 34231259
  2. DEAD-box protein-103 (DP103, Ddx20) is essential for early embryonic development and modulates ovarian morphology and function. Mouillet JF, et al. Endocrinology, 2008 May. PMID 18258677, Free PMC Article
  3. The DEAD-box protein DP103 (Ddx20 or Gemin-3) represses orphan nuclear receptor activity via SUMO modification. Lee MB, et al. Mol Cell Biol, 2005 Mar. PMID 15713642, Free PMC Article
  4. The Ddx20/DP103 dead box protein represses transcriptional activation by Egr2/Krox-20. Gillian AL, et al. J Biol Chem, 2004 Mar 5. PMID 14699164
  5. The DEAD box protein DP103 is a regulator of steroidogenic factor-1. Ou Q, et al. Mol Endocrinol, 2001 Jan. PMID 11145740

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Ddx20, DEAD box helicase 20, is essential for the differentiation of oligodendrocyte and maintenance of myelin gene expression.
    Title: Ddx20, DEAD box helicase 20, is essential for the differentiation of oligodendrocyte and maintenance of myelin gene expression.
  2. Diverse functions for murine DP103, with an obligatory role during early embryonic development and also in modulation of steroidogenesis.
    Title: DEAD-box protein-103 (DP103, Ddx20) is essential for early embryonic development and modulates ovarian morphology and function.
  3. DP103 directly interacts with sumoylated SF-1 and is coupled to transcriptional repression by protein sumoylation.
    Title: The DEAD-box protein DP103 (Ddx20 or Gemin-3) represses orphan nuclear receptor activity via SUMO modification.
  4. Ddx20 repressed Egr2-mediated transcriptional activation with significant promoter specificity
    Title: The Ddx20/DP103 dead box protein represses transcriptional activation by Egr2/Krox-20.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Clone Names

  • MGC159174

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor binding ISO
Inferred from Sequence Orthology
more info
  
enables RNA helicase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables helicase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone deacetylase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein domain specific binding ISO
Inferred from Sequence Orthology
more info
  
enables protein-macromolecule adaptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ribonucleoside triphosphate phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within RNA splicing IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within mRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within oogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of steroid biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in spliceosomal snRNP assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in spliceosomal snRNP assembly ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of RNA polymerase II transcription repressor complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of SMN complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of SMN complex ISO
Inferred from Sequence Orthology
more info
  
part_of SMN-Sm protein complex ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of transcription repressor complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
probable ATP-dependent RNA helicase DDX20
Names
DEAD (Asp-Glu-Ala-Asp) box polypeptide 20
DEAD box protein 20
DEAD box protein DP 103
DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 20
ROSF-1
component of gems 3
gemin-3
regulator of steroidogenic factor 1
NP_059093.3
XP_006501764.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017397.3 → NP_059093.3  probable ATP-dependent RNA helicase DDX20

    See identical proteins and their annotated locations for NP_059093.3

    Status: PROVISIONAL

    Source sequence(s)
    BC125471
    Consensus CDS
    CCDS38581.1
    UniProtKB/Swiss-Prot
    Q059Z6, Q9JIK4, Q9JJY4
    UniProtKB/TrEMBL
    Q8R4Z6
    Related
    ENSMUSP00000088176.7, ENSMUST00000090680.11
    Conserved Domains (2) summary
    PRK01297
    Location:18 → 413
    PRK01297; ATP-dependent RNA helicase RhlB; Provisional
    cd17943
    Location:74 → 266
    DEADc_DDX20; DEAD-box helicase domain of DEAD box protein 20

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    105585586..105595104 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006501701.4 → XP_006501764.1  probable ATP-dependent RNA helicase DDX20 isoform X1

    See identical proteins and their annotated locations for XP_006501764.1

    UniProtKB/Swiss-Prot
    Q059Z6, Q9JIK4, Q9JJY4
    UniProtKB/TrEMBL
    Q8R4Z6
    Conserved Domains (2) summary
    PRK01297
    Location:18 → 413
    PRK01297; ATP-dependent RNA helicase RhlB; Provisional
    cd17943
    Location:74 → 266
    DEADc_DDX20; DEAD-box helicase domain of DEAD box protein 20
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9JJY4.2 GenPept UniProtKB/Swiss-Prot:Q9JJY4

Gene LinkOut

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