Slc40a1 solute carrier family 40 (iron-regulated transporter), member 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Slc40a1provided by MGI
Official Full Name: solute carrier family 40 (iron-regulated transporter), member 1provided by MGI
Primary source: MGI:MGI:1315204
See related: Ensembl:ENSMUSG00000025993 AllianceGenome:MGI:1315204
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: MTP; Ol5; Pcm; Dusg; Fpn1; MTP1; IREG1; Slc11a3; Slc39a1
Summary: Enables ferrous iron transmembrane transporter activity; identical protein binding activity; and peptide hormone binding activity. Involved in iron ion export across plasma membrane. Acts upstream of or within several processes, including multicellular organismal iron ion homeostasis; regulation of transcription by RNA polymerase II; and spleen trabecula formation. Located in basolateral plasma membrane and synaptic vesicle. Is expressed in several structures, including central nervous system; extraembryonic component; genitourinary system; gut; and hemolymphoid system gland. Used to study hemochromatosis type 4. Human ortholog(s) of this gene implicated in hemochromatosis type 4. Orthologous to human SLC40A1 (solute carrier family 40 member 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in liver E18 (RPKM 41.3), placenta adult (RPKM 28.4) and 21 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 C1.1; 1 23.96 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (45947230..45965690, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (45908070..45926532, complement)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Elevated SLC40A1 impairs cardiac function and exacerbates mitochondrial dysfunction, oxidative stress, and apoptosis in ischemic myocardia.
Title: Elevated SLC40A1 impairs cardiac function and exacerbates mitochondrial dysfunction, oxidative stress, and apoptosis in ischemic myocardia.
Role of hepcidin upregulation and proteolytic cleavage of ferroportin 1 in hepatitis C virus-induced iron accumulation.
Title: Role of hepcidin upregulation and proteolytic cleavage of ferroportin 1 in hepatitis C virus-induced iron accumulation.
Cdh5-mediated Fpn1 deletion exerts neuroprotective effects during the acute phase and inhibitory effects during the recovery phase of ischemic stroke.
Title: Cdh5-mediated Fpn1 deletion exerts neuroprotective effects during the acute phase and inhibitory effects during the recovery phase of ischemic stroke.
Astrocyte-derived hepcidin controls iron traffic at the blood-brain-barrier via regulating ferroportin 1 of microvascular endothelial cells.
Title: Astrocyte-derived hepcidin controls iron traffic at the blood-brain-barrier via regulating ferroportin 1 of microvascular endothelial cells.
Salmonella effector SpvB aggravates dysregulation of systemic iron metabolism via modulating the hepcidin-ferroportin axis.
Title: Salmonella effector SpvB aggravates dysregulation of systemic iron metabolism via modulating the hepcidin-ferroportin axis.
RNF217 regulates iron homeostasis through its E3 ubiquitin ligase activity by modulating ferroportin degradation.
Title: RNF217 regulates iron homeostasis through its E3 ubiquitin ligase activity by modulating ferroportin degradation.
Fasting Increases Iron Export by Modulating Ferroportin 1 Expression Through the Ghrelin/GHSR1alpha/MAPK Pathway in the Liver.
Title: Fasting Increases Iron Export by Modulating Ferroportin 1 Expression Through the Ghrelin/GHSR1α/MAPK Pathway in the Liver.
Marginally reduced maternal hepatic and splenic ferroportin under severe nutritional iron deficiency in pregnancy maintains systemic iron supply.
Title: Marginally reduced maternal hepatic and splenic ferroportin under severe nutritional iron deficiency in pregnancy maintains systemic iron supply.
Brain iron deficiency and affected contextual fear memory in mice with conditional Ferroportin1 ablation in the brain.
Title: Brain iron deficiency and affected contextual fear memory in mice with conditional Ferroportin1 ablation in the brain.
Iron Dyshomeostasis Induces Binding of APP to BACE1 for Amyloid Pathology, and Impairs APP/Fpn1 Complex in Microglia: Implication in Pathogenesis of Cerebral Microbleeds.
Title: Iron Dyshomeostasis Induces Binding of APP to BACE1 for Amyloid Pathology, and Impairs APP/Fpn1 Complex in Microglia: Implication in Pathogenesis of Cerebral Microbleeds.

Submit: New GeneRIF Correction See all GeneRIFs (77)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (9) 1 citation
Radiation induced (1)
Chemically induced (ENU) (1) 1 citation
Endonuclease-mediated (3)

General gene information

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Markers

Slc40a1 (e-PCR), detects polymorphism
- UniSTS:547110

BB284629 (e-PCR)
- UniSTS:207156

NoName (e-PCR)
- UniSTS:234123

Slc40a1 (e-PCR), detects polymorphism
- UniSTS:496015

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ferrous iron transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables iron ion transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables iron ion transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables iron ion transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables peptide hormone binding	IBA Inferred from Biological aspect of Ancestor more info
enables peptide hormone binding	IPI Inferred from Physical Interaction more info	PubMed
enables peptide hormone binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within endothelium development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within establishment of localization in cell	IGI Inferred from Genetic Interaction more info	PubMed
involved_in intracellular iron ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in iron ion export across plasma membrane	IDA Inferred from Direct Assay more info	PubMed
involved_in iron ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within iron ion transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within iron ion transmembrane transport	IGI Inferred from Genetic Interaction more info	PubMed
involved_in iron ion transmembrane transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within iron ion transport	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within lymphocyte homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within monoatomic ion transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within multicellular organismal-level iron ion homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in multicellular organismal-level iron ion homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within spleen development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within spleen trabecula formation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
is_active_in basolateral plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in basolateral plasma membrane	IGI Inferred from Genetic Interaction more info	PubMed
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in synaptic vesicle	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: solute carrier family 40 member 1

Names: SLC11A3 iron transporter; duodenal-specific; ferroportin 1; ferroportin1; iron-regulated transporter 1; metal transporter protein 1; metal transporting protein 1; polycythaemia; solute carrier family 11 (proton-coupled divalent metal ion transporters), member 3; solute carrier family 39 (iron-regulated transporter), member 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.