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RAB24 RAB24, member RAS oncogene family [ Homo sapiens (human) ]

Gene ID: 53917, updated on 5-Mar-2024

Summary

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Official Symbol
RAB24provided by HGNC
Official Full Name
RAB24, member RAS oncogene familyprovided by HGNC
Primary source
HGNC:HGNC:9765
See related
Ensembl:ENSG00000169228 MIM:612415; AllianceGenome:HGNC:9765
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
RAB24 is a small GTPase of the Rab subfamily of Ras-related proteins that regulate intracellular protein trafficking (Olkkonen et al., 1993 [PubMed 8126105]).[supplied by OMIM, Aug 2009]
Expression
Ubiquitous expression in spleen (RPKM 20.5), appendix (RPKM 14.7) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
5q35.3
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (177301198..177303719, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (177844433..177846953, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (176728199..176730720, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene nuclear receptor binding SET domain protein 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:176692158-176693050 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:176693051-176693942 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr5:176696443-176697642 Neighboring gene ribosomal protein L21 pseudogene 60 Neighboring gene protein arginine methyltransferase 1 pseudogene 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:176722701-176723202 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:176723203-176723702 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:176727388-176727581 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr5:176728411-176729610 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16677 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:176730775-176731652 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23699 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23700 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23701 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23702 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23703 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:176737000-176737866 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23704 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16680 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16681 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23705 Neighboring gene Sharpr-MPRA regulatory region 13731 Neighboring gene PRELI domain containing 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:176746939-176747440 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:176747441-176747940 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:176751079-176751579 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr5:176753137-176754080 Neighboring gene MAX dimerization protein 3 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:176763024-176763649 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:176765883-176766836 Neighboring gene lectin, mannose binding 2 Neighboring gene ribosomal protein S20 pseudogene 17

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Hepatic Rab24 controls blood glucose homeostasis via improving mitochondrial plasticity. Seitz S, et al. Nat Metab, 2019 Oct. PMID 32694843
  2. Rab24 interacts with the Rab7/Rab interacting lysosomal protein complex to regulate endosomal degradation. Amaya C, et al. Traffic, 2016 Nov. PMID 27550070
  3. Rab24 is required for normal cell division. Militello RD, et al. Traffic, 2013 May. PMID 23387408
  4. Mutant Rab24 GTPase is targeted to nuclear inclusions. Maltese WA, et al. BMC Cell Biol, 2002 Sep 25. PMID 12323076, Free PMC Article
  5. Rab24 is an atypical member of the Rab GTPase family. Deficient GTPase activity, GDP dissociation inhibitor interaction, and prenylation of Rab24 expressed in cultured cells. Erdman RA, et al. J Biol Chem, 2000 Feb 11. PMID 10660536

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Hepatic Rab24 controls blood glucose homeostasis via improving mitochondrial plasticity.
    Title: Hepatic Rab24 controls blood glucose homeostasis via improving mitochondrial plasticity.
  2. Our work provides new insights into the molecular function of Rab24 in the last steps of the endosomal degradative pathway.
    Title: Rab24 interacts with the Rab7/Rab interacting lysosomal protein complex to regulate endosomal degradation.
  3. Rab24 modulates several mitotic events, including chromosome segregation and cytokinesis, perhaps through the interaction with microtubules
    Title: Rab24 is required for normal cell division.
  4. Observational study of gene-disease association. (HuGE Navigator)
    Title: Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Potential readthrough

Included gene: MXD3

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in autophagy IEA
Inferred from Electronic Annotation
more info
  
involved_in intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in autophagosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
  
is_active_in endomembrane system IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  
located_in secretory granule membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
ras-related protein Rab-24

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001031677.4 → NP_001026847.1  ras-related protein Rab-24

    See identical proteins and their annotated locations for NP_001026847.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the functional protein. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AF087904, AI868941, AV698158, BC021263, DA898352
    Consensus CDS
    CCDS34300.1
    UniProtKB/Swiss-Prot
    A0A024R7N9, Q7Z4Z7, Q969Q5
    UniProtKB/TrEMBL
    F8W8H5
    Related
    ENSP00000304376.6, ENST00000303251.11
    Conserved Domains (1) summary
    cd04118
    Location:8 → 201
    Rab24; Rab GTPase family 24 (Rab24)

  2. NM_130781.4 → NP_570137.2  ras-related protein Rab-24

    See identical proteins and their annotated locations for NP_570137.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AF087904, AI868941, AV698158, BC015534, DA898352
    Consensus CDS
    CCDS34300.1
    UniProtKB/Swiss-Prot
    A0A024R7N9, Q7Z4Z7, Q969Q5
    UniProtKB/TrEMBL
    F8W8H5
    Related
    ENSP00000377235.2, ENST00000393611.6
    Conserved Domains (1) summary
    cd04118
    Location:8 → 201
    Rab24; Rab GTPase family 24 (Rab24)

RNA

  1. NR_109789.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks a segment in the 5' region, and includes an additional internal segment, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AF087904, AF258583, AI868941, AK308155, AV698158, DA898352

  2. NR_109790.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) includes an additional internal segment, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AF087904, AF258583, AI868941, AV698158, DA058886
    Related
    ENST00000478234.5

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    177301198..177303719 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    177844433..177846953 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q969Q5.1 GenPept UniProtKB/Swiss-Prot:Q969Q5

Gene LinkOut

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