Rcan3 regulator of calcineurin 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rcan3provided by MGI
Official Full Name: regulator of calcineurin 3provided by MGI
Primary source: MGI:MGI:1858220
See related: Ensembl:ENSMUSG00000059713 AllianceGenome:MGI:1858220
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Csp3; Dscr1l2
Summary: Predicted to enable calcium-dependent protein serine/threonine phosphatase regulator activity; phosphatase binding activity; and troponin I binding activity. Predicted to be involved in calcium-mediated signaling. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including brain; genitourinary system; liver; lung; and spleen. Orthologous to human RCAN3 (RCAN family member 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in cerebellum adult (RPKM 17.8), CNS E18 (RPKM 16.6) and 26 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 D3; 4 67.59 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (135139619..135161154, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (135412308..135433871, complement)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The PxIxIT motif of the RCAN3 inhibits angiogenesis and tumor progression in Triple Negative breast cancer in immunocompetent mice.
Title: The PxIxIT motif of the RCAN3 inhibits angiogenesis and tumor progression in Triple Negative breast cancer in immunocompetent mice.
found that RCAN1/3 interact with RAF kinases and CN in a non-exclusive manner. Our data suggests that the balance of RCAN interactions with CN and/or RAF kinases may influence T cell positive selection
Title: RCAN 1 and 3 proteins regulate thymic positive selection.
the adult mice, RCAN3 was mainly expressed in the neuropil throughout the brain.
Title: Differential expression of members of the RCAN family of calcineurin regulators suggests selective functions for these proteins in the brain.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)

General gene information

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Markers

AU041093 (e-PCR)
- UniSTS:159308

Rcan3 (e-PCR), detects polymorphism
- UniSTS:499087

Dscr1l2 (e-PCR), detects polymorphism
- UniSTS:186517

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables calcium-dependent protein serine/threonine phosphatase regulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables phosphatase binding	ISO Inferred from Sequence Orthology more info
enables troponin I binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in calcium-mediated signaling	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: calcipressin-3

Names: Down syndrome critical region gene 1-like 2; MCIP3; down syndrome candidate region 1-like protein 2; myocyte-enriched calcineurin-interacting protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.