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Sart3 squamous cell carcinoma antigen recognized by T cells 3 [ Mus musculus (house mouse) ]

Gene ID: 53890, updated on 11-Apr-2024

Summary

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Official Symbol
Sart3provided by MGI
Official Full Name
squamous cell carcinoma antigen recognized by T cells 3provided by MGI
Primary source
MGI:MGI:1858230
See related
Ensembl:ENSMUSG00000018974 AllianceGenome:MGI:1858230
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA0156
Summary
Predicted to enable histone binding activity; snRNA binding activity; and ubiquitin-specific protease binding activity. Acts upstream of or within cell morphogenesis; hematopoietic stem cell proliferation; and homeostasis of number of cells. Located in Cajal body. Is expressed in several structures, including genitourinary system; heart; hemolymphoid system; liver; and lung. Orthologous to human SART3 (spliceosome associated factor 3, U4/U6 recycling protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 20.4), CNS E14 (RPKM 11.1) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
5 F; 5 55.55 cM
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (113880505..113910461, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (113742444..113772400, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700069L16 gene Neighboring gene predicted gene, 46919 Neighboring gene STARR-positive B cell enhancer ABC_E2171 Neighboring gene FIC domain containing Neighboring gene STARR-seq mESC enhancer starr_14052 Neighboring gene STARR-positive B cell enhancer ABC_E9260 Neighboring gene 40S ribosomal protein S28 pseudogene Neighboring gene iron-sulfur cluster assembly enzyme Neighboring gene transmembrane protein 119

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Identification of a gene coding for a protein possessing shared tumor epitopes capable of inducing HLA-A24-restricted cytotoxic T lymphocytes in cancer patients. Yang D, et al. Cancer Res, 1999 Aug 15. PMID 10463607
  2. Targeting of U4/U6 small nuclear RNP assembly factor SART3/p110 to Cajal bodies. Stanĕk D, et al. J Cell Biol, 2003 Feb 17. PMID 12578909, Free PMC Article
  3. Mouse homologue of the human SART3 gene encoding tumor-rejection antigen. Harada K, et al. Jpn J Cancer Res, 2000 Feb. PMID 10761712, Free PMC Article
  4. Tip110 Deletion Impaired Embryonic and Stem Cell Development Involving Downregulation of Stem Cell Factors Nanog, Oct4, and Sox2. Whitmill A, et al. Stem Cells, 2017 Jul. PMID 28436127
  5. TIP110/p110nrb/SART3/p110 regulation of hematopoiesis through CMYC. Liu Y, et al. Blood, 2011 May 26. PMID 21447833, Free PMC Article

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (5)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables U6 snRNA binding ISO
Inferred from Sequence Orthology
more info
  
enables U6atac snRNA binding ISO
Inferred from Sequence Orthology
more info
  
enables histone binding ISO
Inferred from Sequence Orthology
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin-specific protease binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in RNA processing IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within RNA splicing IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within hematopoietic stem cell proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within homeostasis of number of cells IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within mRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mRNA splicing, via spliceosome ISO
Inferred from Sequence Orthology
more info
  
involved_in nucleosome assembly ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in spliceosomal snRNP assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in spliceosomal tri-snRNP complex assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in transcription elongation-coupled chromatin remodeling ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of ASAP complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Cajal body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in Cajal body ISO
Inferred from Sequence Orthology
more info
  
part_of U4/U6 snRNP ISO
Inferred from Sequence Orthology
more info
  
part_of U6atac snRNP ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 PubMed 

General protein information

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Preferred Names
squamous cell carcinoma antigen recognized by T-cells 3
Names
SART-3
mSART-3
tumor-rejection antigen SART3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001356621.1 → NP_001343550.1  squamous cell carcinoma antigen recognized by T-cells 3 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC132939
    Conserved Domains (4) summary
    cd12391
    Location:723 → 796
    RRM1_SART3; RNA recognition motif 1 in squamous cell carcinoma antigen recognized by T-cells 3 (SART3) and similar proteins
    cd12392
    Location:817 → 897
    RRM2_SART3; RNA recognition motif 2 in squamous cell carcinoma antigen recognized by T-cells 3 (SART3) and similar proteins
    pfam16605
    Location:895 → 953
    LSM_int_assoc; LSM-interacting associated unstructured
    cl26993
    Location:101 → 479
    Suf; Suppressor of forked protein (Suf)

  2. NM_001356623.1 → NP_001343552.1  squamous cell carcinoma antigen recognized by T-cells 3 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice junction compared to variant 1. The resulting isoform (3) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AC132939
    Conserved Domains (3) summary
    cd12391
    Location:316 → 389
    RRM1_SART3; RNA recognition motif 1 in squamous cell carcinoma antigen recognized by T-cells 3 (SART3) and similar proteins
    cd12392
    Location:410 → 490
    RRM2_SART3; RNA recognition motif 2 in squamous cell carcinoma antigen recognized by T-cells 3 (SART3) and similar proteins
    cl25617
    Location:488 → 546
    LSM_int_assoc; LSM-interacting associated unstructured

  3. NM_016926.2 → NP_058622.1  squamous cell carcinoma antigen recognized by T-cells 3 isoform 2

    See identical proteins and their annotated locations for NP_058622.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AC132939, AK086398
    Consensus CDS
    CCDS19552.1
    UniProtKB/Swiss-Prot
    Q6ZQI2, Q8BPK9, Q8C3B7, Q8CFU9, Q9JLI8
    Related
    ENSMUSP00000019118.4, ENSMUST00000019118.8
    Conserved Domains (7) summary
    COG0724
    Location:641 → 858
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    COG5107
    Location:101 → 461
    RNA14; Pre-mRNA 3'-end processing (cleavage and polyadenylation) factor [RNA processing and modification]
    cd12391
    Location:705 → 778
    RRM1_SART3; RNA recognition motif 1 in squamous cell carcinoma antigen recognized by T-cells 3 (SART3) and similar proteins
    cd12392
    Location:799 → 879
    RRM2_SART3; RNA recognition motif 2 in squamous cell carcinoma antigen recognized by T-cells 3 (SART3) and similar proteins
    pfam05391
    Location:944 → 961
    Lsm_interact; Lsm interaction motif
    pfam08424
    Location:334 → 487
    NRDE-2; NRDE-2, necessary for RNA interference
    pfam16605
    Location:877 → 935
    LSM_int_assoc; LSM-interacting associated unstructured

RNA

  1. NR_151532.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) has several differences compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC132939
    Related
    ENSMUST00000197041.2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    113880505..113910461 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030254699.1 → XP_030110559.1  squamous cell carcinoma antigen recognized by T-cells 3 isoform X2

    Conserved Domains (5) summary
    COG5107
    Location:1 → 323
    RNA14; Pre-mRNA 3'-end processing (cleavage and polyadenylation) factor [RNA processing and modification]
    cd12391
    Location:567 → 640
    RRM1_SART3; RNA recognition motif 1 in squamous cell carcinoma antigen recognized by T-cells 3 (SART3) and similar proteins
    cd12392
    Location:661 → 741
    RRM2_SART3; RNA recognition motif 2 in squamous cell carcinoma antigen recognized by T-cells 3 (SART3) and similar proteins
    pfam05391
    Location:806 → 823
    Lsm_interact; Lsm interaction motif
    pfam16605
    Location:739 → 797
    LSM_int_assoc; LSM-interacting associated unstructured

  2. XM_006530406.1 → XP_006530469.1  squamous cell carcinoma antigen recognized by T-cells 3 isoform X1

    Conserved Domains (5) summary
    COG5107
    Location:1 → 341
    RNA14; Pre-mRNA 3'-end processing (cleavage and polyadenylation) factor [RNA processing and modification]
    cd12391
    Location:585 → 658
    RRM1_SART3; RNA recognition motif 1 in squamous cell carcinoma antigen recognized by T-cells 3 (SART3) and similar proteins
    cd12392
    Location:679 → 759
    RRM2_SART3; RNA recognition motif 2 in squamous cell carcinoma antigen recognized by T-cells 3 (SART3) and similar proteins
    pfam05391
    Location:824 → 841
    Lsm_interact; Lsm interaction motif
    pfam16605
    Location:757 → 815
    LSM_int_assoc; LSM-interacting associated unstructured
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9JLI8.1 GenPept UniProtKB/Swiss-Prot:Q9JLI8

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