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Cdkl2 cyclin dependent kinase like 2 [ Mus musculus (house mouse) ]

Gene ID: 53886, updated on 21-Apr-2024

Summary

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Official Symbol
Cdkl2provided by MGI
Official Full Name
cyclin dependent kinase like 2provided by MGI
Primary source
MGI:MGI:1858227
See related
Ensembl:ENSMUSG00000029403 AllianceGenome:MGI:1858227
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Kkm; KKIAMRE; 5330436L21Rik
Summary
Predicted to enable cyclin-dependent protein serine/threonine kinase activity. Predicted to be involved in protein phosphorylation. Predicted to act upstream of or within phosphorylation. Predicted to be located in centrosome and nucleoplasm. Predicted to be active in nucleus. Is expressed in brain; genitourinary system; and parathyroid gland. Orthologous to human CDKL2 (cyclin dependent kinase like 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 6.7), CNS E18 (RPKM 3.6) and 14 other tissues See more
Orthologs
human all
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Genomic context

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Location:
5 E2; 5 45.73 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (92153933..92198479, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (92006074..92043042, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_13622 Neighboring gene ring finger and CHY zinc finger domain containing 1 Neighboring gene STARR-seq mESC enhancer starr_13623 Neighboring gene THAP domain containing 6 Neighboring gene STARR-seq mESC enhancer starr_13624 Neighboring gene odontogenesis associated phosphoprotein Neighboring gene predicted gene, 46915 Neighboring gene STARR-positive B cell enhancer mm9_chr5:92471665-92471966 Neighboring gene predicted gene, 22728 Neighboring gene G3BP stress granule assembly factor 2 Neighboring gene predicted gene, 42111

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Involvement of cyclin-dependent kinase-like 2 in cognitive function required for contextual and spatial learning in mice. Gomi H, et al. Front Behav Neurosci, 2010. PMID 20428496, Free PMC Article
  2. Postnatal expression of Cdkl2 in mouse brain revealed by LacZ inserted into the Cdkl2 locus. Sassa T, et al. Cell Tissue Res, 2004 Feb. PMID 14605869
  3. Identification of variants and dual promoters of murine serine/threonine kinase KKIAMRE. Sassa T, et al. J Neurochem, 2000 May. PMID 10800923
  4. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article
  5. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (2) 

General gene information

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Markers

Homology

Clone Names

  • MGC144031, MGC144032

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables cyclin-dependent protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
cyclin-dependent kinase-like 2
Names
cyclin dependent kinase like 2 (CDC2 related kinase)
NP_001263244.1
NP_058608.1
NP_796244.2
XP_011247839.1
XP_011247840.1
XP_011247841.1
XP_017176476.1
XP_017176477.1
XP_017176479.1
XP_036021189.1
XP_036021190.1
XP_036021191.1
XP_036021192.1
XP_036021193.1
XP_036021194.1
XP_036021195.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001276315.1 → NP_001263244.1  cyclin-dependent kinase-like 2 isoform 2

    See identical proteins and their annotated locations for NP_001263244.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and lacks an alternate exon, which results in a frameshift in the 3' coding region, compared to variant 1. Variants 2 and 3 encode the same isoform (2, also known as gamma) which is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AB029066, AK030598, AK139820, BB616412, CD348339
    Consensus CDS
    CCDS19425.1
    UniProtKB/Swiss-Prot
    Q9QUK0
    Related
    ENSMUSP00000108768.2, ENSMUST00000113143.8
    Conserved Domains (2) summary
    smart00220
    Location:4 → 289
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd07846
    Location:2 → 289
    STKc_CDKL2_3; Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase Like 2 and 3

  2. NM_016912.2 → NP_058608.1  cyclin-dependent kinase-like 2 isoform 1

    See identical proteins and their annotated locations for NP_058608.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1, also known as beta).
    Source sequence(s)
    AB029065, AB029066, AC165433, CD348339, CJ047658
    Consensus CDS
    CCDS19426.1
    UniProtKB/Swiss-Prot
    Q3UL60, Q3V3X7, Q9QUK0, Q9QYI1, Q9QYI2
    UniProtKB/TrEMBL
    Q149A0
    Related
    ENSMUSP00000084199.6, ENSMUST00000086978.12
    Conserved Domains (1) summary
    cd07846
    Location:2 → 289
    STKc_CDKL2_3; Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase Like 2 and 3

  3. NM_177270.4 → NP_796244.2  cyclin-dependent kinase-like 2 isoform 2

    See identical proteins and their annotated locations for NP_796244.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon, which results in a frameshift in the 3' coding region, compared to variant 1. Variants 2 and 3 encode the same isoform (2, also known as gamma) which is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AB029066, AC165433, CD348339, CJ047658
    Consensus CDS
    CCDS19425.1
    UniProtKB/Swiss-Prot
    Q9QUK0
    Related
    ENSMUSP00000063617.5, ENSMUST00000069937.11
    Conserved Domains (2) summary
    smart00220
    Location:4 → 289
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd07846
    Location:2 → 289
    STKc_CDKL2_3; Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase Like 2 and 3

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    92153933..92198479 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036165300.1 → XP_036021193.1  cyclin-dependent kinase-like 2 isoform X6

    Conserved Domains (1) summary
    cl21453
    Location:2 → 224
    PKc_like; Protein Kinases, catalytic domain

  2. XM_036165297.1 → XP_036021190.1  cyclin-dependent kinase-like 2 isoform X2

    Conserved Domains (1) summary
    cd07846
    Location:2 → 289
    STKc_CDKL2_3; Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase Like 2 and 3

  3. XM_036165299.1 → XP_036021192.1  cyclin-dependent kinase-like 2 isoform X4

    Conserved Domains (1) summary
    cd07846
    Location:2 → 289
    STKc_CDKL2_3; Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase Like 2 and 3

  4. XM_017320987.3 → XP_017176476.1  cyclin-dependent kinase-like 2 isoform X1

    UniProtKB/Swiss-Prot
    Q3UL60, Q3V3X7, Q9QUK0, Q9QYI1, Q9QYI2
    UniProtKB/TrEMBL
    Q149A0
    Related
    ENSMUSP00000108765.2, ENSMUST00000113140.5
    Conserved Domains (1) summary
    cd07846
    Location:2 → 289
    STKc_CDKL2_3; Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase Like 2 and 3

  5. XM_036165298.1 → XP_036021191.1  cyclin-dependent kinase-like 2 isoform X4

    Conserved Domains (1) summary
    cd07846
    Location:2 → 289
    STKc_CDKL2_3; Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase Like 2 and 3

  6. XM_011249538.3 → XP_011247840.1  cyclin-dependent kinase-like 2 isoform X3

    Conserved Domains (1) summary
    cd07846
    Location:2 → 289
    STKc_CDKL2_3; Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase Like 2 and 3

  7. XM_011249537.4 → XP_011247839.1  cyclin-dependent kinase-like 2 isoform X1

    See identical proteins and their annotated locations for XP_011247839.1

    UniProtKB/Swiss-Prot
    Q3UL60, Q3V3X7, Q9QUK0, Q9QYI1, Q9QYI2
    UniProtKB/TrEMBL
    Q149A0
    Conserved Domains (1) summary
    cd07846
    Location:2 → 289
    STKc_CDKL2_3; Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase Like 2 and 3

  8. XM_017320988.2 → XP_017176477.1  cyclin-dependent kinase-like 2 isoform X1

    UniProtKB/Swiss-Prot
    Q3UL60, Q3V3X7, Q9QUK0, Q9QYI1, Q9QYI2
    UniProtKB/TrEMBL
    Q149A0
    Conserved Domains (1) summary
    cd07846
    Location:2 → 289
    STKc_CDKL2_3; Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase Like 2 and 3

  9. XM_036165301.1 → XP_036021194.1  cyclin-dependent kinase-like 2 isoform X7

    Conserved Domains (1) summary
    cl21453
    Location:2 → 224
    PKc_like; Protein Kinases, catalytic domain

  10. XM_036165296.1 → XP_036021189.1  cyclin-dependent kinase-like 2 isoform X2

    Conserved Domains (1) summary
    cd07846
    Location:2 → 289
    STKc_CDKL2_3; Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase Like 2 and 3

  11. XM_011249539.3 → XP_011247841.1  cyclin-dependent kinase-like 2 isoform X5

    Conserved Domains (1) summary
    cd07846
    Location:2 → 289
    STKc_CDKL2_3; Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase Like 2 and 3

  12. XM_036165302.1 → XP_036021195.1  cyclin-dependent kinase-like 2 isoform X9

    Conserved Domains (1) summary
    cd07846
    Location:2 → 289
    STKc_CDKL2_3; Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase Like 2 and 3

  13. XM_017320990.3 → XP_017176479.1  cyclin-dependent kinase-like 2 isoform X8

    Conserved Domains (1) summary
    cd07846
    Location:2 → 289
    STKc_CDKL2_3; Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase Like 2 and 3
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9QUK0.1 GenPept UniProtKB/Swiss-Prot:Q9QUK0

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