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Pkd2l2 polycystic kidney disease 2-like 2 [ Mus musculus (house mouse) ]

Gene ID: 53871, updated on 21-Apr-2024

Summary

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Official Symbol
Pkd2l2provided by MGI
Official Full Name
polycystic kidney disease 2-like 2provided by MGI
Primary source
MGI:MGI:1858231
See related
Ensembl:ENSMUSG00000014503 AllianceGenome:MGI:1858231
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
TRPP5
Summary
Predicted to enable calcium channel activity. Predicted to be involved in detection of mechanical stimulus. Predicted to act upstream of or within ion transport. Predicted to be integral component of membrane. Predicted to be active in membrane. Is expressed in several structures, including cochlea; gonad; pancreas; spleen; and stomach. Orthologous to human PKD2L2 (polycystin 2 like 2, transient receptor potential cation channel). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 6.3), CNS E18 (RPKM 6.2) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
18 B1; 18 18.62 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (34541553..34575842)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (34408501..34442798)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene signal recognition particle 19 Neighboring gene receptor accessory protein 5 Neighboring gene STARR-positive B cell enhancer ABC_E8999 Neighboring gene SET translocation pseudogene Neighboring gene family with sequence similarity 13, member B Neighboring gene STARR-seq mESC enhancer starr_44201 Neighboring gene STARR-seq mESC enhancer starr_44203 Neighboring gene STARR-seq mESC enhancer starr_44204 Neighboring gene STARR-seq mESC enhancer starr_44205 Neighboring gene STARR-seq mESC enhancer starr_44207 Neighboring gene wingless-type MMTV integration site family, member 8A Neighboring gene STARR-positive B cell enhancer mm9_chr18:34732422-34732722 Neighboring gene NME/NM23 family member 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Expression of Pkd2l2 in testis is implicated in spermatogenesis. Chen Y, et al. Biol Pharm Bull, 2008 Aug. PMID 18670078
  2. Identification and characterization of a novel polycystin family member, polycystin-L2, in mouse and human: sequence, expression, alternative splicing, and chromosomal localization. Guo L, et al. Genomics, 2000 Mar 15. PMID 10756092
  3. Polycystin-2 expression and function in adult mouse lacrimal acinar cells. Kaja S, et al. Invest Ophthalmol Vis Sci, 2011 Jul 29. PMID 21508103, Free PMC Article
  4. Hair-Cell Mechanotransduction Persists in TRP Channel Knockout Mice. Wu X, et al. PLoS One, 2016. PMID 27196058, Free PMC Article
  5. Two members of the TRPP family of ion channels, Pkd1l3 and Pkd2l1, are co-expressed in a subset of taste receptor cells. LopezJimenez ND, et al. J Neurochem, 2006 Jul. PMID 16805797

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (3) 
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in detection of mechanical stimulus IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
polycystin-2-like protein 2
Names
Polycystin - L2
polycystic kidney disease 2-like 2 protein
polycystin-2L2
polycystin-L2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163004.1 → NP_001156476.1  polycystin-2-like protein 2

    See identical proteins and their annotated locations for NP_001156476.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC090534, AK133423, BC138717
    Consensus CDS
    CCDS29127.1
    UniProtKB/Swiss-Prot
    B2RS50, Q9JLG4
    UniProtKB/TrEMBL
    Q3V056
    Related
    ENSMUSP00000127257.2, ENSMUST00000166156.9
    Conserved Domains (1) summary
    pfam08016
    Location:76 → 497
    PKD_channel; Polycystin cation channel

  2. NM_016927.3 → NP_058623.2  polycystin-2-like protein 2

    See identical proteins and their annotated locations for NP_058623.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC090534, AC115305, BC138717
    Consensus CDS
    CCDS29127.1
    UniProtKB/Swiss-Prot
    B2RS50, Q9JLG4
    UniProtKB/TrEMBL
    Q3V056
    Related
    ENSMUSP00000014647.8, ENSMUST00000014647.9
    Conserved Domains (1) summary
    pfam08016
    Location:76 → 497
    PKD_channel; Polycystin cation channel

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    34541553..34575842
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017317946.3 → XP_017173435.1  polycystin-2-like protein 2 isoform X3

    UniProtKB/TrEMBL
    Q3V056
    Conserved Domains (1) summary
    pfam08016
    Location:28 → 449
    PKD_channel; Polycystin cation channel

  2. XM_017317949.3 → XP_017173438.1  polycystin-2-like protein 2 isoform X6

    UniProtKB/TrEMBL
    Q3V056
    Conserved Domains (1) summary
    pfam08016
    Location:1 → 407
    PKD_channel; Polycystin cation channel

  3. XM_017317950.3 → XP_017173439.1  polycystin-2-like protein 2 isoform X6

    UniProtKB/TrEMBL
    Q3V056
    Conserved Domains (1) summary
    pfam08016
    Location:1 → 407
    PKD_channel; Polycystin cation channel

  4. XM_017317944.3 → XP_017173433.1  polycystin-2-like protein 2 isoform X1

    UniProtKB/TrEMBL
    Q3V056
    Conserved Domains (1) summary
    pfam08016
    Location:78 → 499
    PKD_channel; Polycystin cation channel

  5. XM_017317948.3 → XP_017173437.1  polycystin-2-like protein 2 isoform X5

    UniProtKB/TrEMBL
    Q3V056
    Conserved Domains (1) summary
    pfam08016
    Location:78 → 442
    PKD_channel; Polycystin cation channel

  6. XM_036161210.1 → XP_036017103.1  polycystin-2-like protein 2 isoform X2

    UniProtKB/TrEMBL
    Q3V056
    Conserved Domains (1) summary
    pfam08016
    Location:43 → 463
    PKD_channel; Polycystin cation channel

  7. XM_017317947.3 → XP_017173436.1  polycystin-2-like protein 2 isoform X3

    UniProtKB/TrEMBL
    Q3V056
    Conserved Domains (1) summary
    pfam08016
    Location:28 → 449
    PKD_channel; Polycystin cation channel

  8. XM_006526097.5 → XP_006526160.1  polycystin-2-like protein 2 isoform X4

    UniProtKB/TrEMBL
    Q3V056
    Conserved Domains (1) summary
    pfam08016
    Location:78 → 499
    PKD_channel; Polycystin cation channel

  9. XM_036161212.1 → XP_036017105.1  polycystin-2-like protein 2 isoform X7

    UniProtKB/TrEMBL
    Q3V056
    Conserved Domains (1) summary
    pfam08016
    Location:79 → 499
    PKD_channel; Polycystin cation channel

  10. XM_017317951.3 → XP_017173440.1  polycystin-2-like protein 2 isoform X7

    UniProtKB/TrEMBL
    Q3V056
    Conserved Domains (1) summary
    pfam08016
    Location:79 → 499
    PKD_channel; Polycystin cation channel

  11. XM_006526101.5 → XP_006526164.1  polycystin-2-like protein 2 isoform X7

    UniProtKB/TrEMBL
    Q3V056
    Conserved Domains (1) summary
    pfam08016
    Location:79 → 499
    PKD_channel; Polycystin cation channel

  12. XM_006526104.4 → XP_006526167.1  polycystin-2-like protein 2 isoform X8

    UniProtKB/TrEMBL
    Q3UQ78
    Conserved Domains (1) summary
    pfam08016
    Location:78 → 281
    PKD_channel; Polycystin cation channel
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9JLG4.2 GenPept UniProtKB/Swiss-Prot:Q9JLG4

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