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Prg3 proteoglycan 3 [ Mus musculus (house mouse) ]

Gene ID: 53856, updated on 21-Apr-2024

Summary

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Official Symbol
Prg3provided by MGI
Official Full Name
proteoglycan 3provided by MGI
Primary source
MGI:MGI:1858200
See related
Ensembl:ENSMUSG00000027072 AllianceGenome:MGI:1858200
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MBP2; MBPH
Summary
Predicted to enable carbohydrate binding activity. Predicted to be involved in several processes, including granulocyte activation; histamine biosynthetic process; and regulation of gene expression. Is expressed in several structures, including gut; hemolymphoid system; liver; lung; and reproductive system. Orthologous to human PRG3 (proteoglycan 3, pro eosinophil major basic protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in liver E18 (RPKM 1.5), liver E14 (RPKM 1.4) and 6 other tissues See more
Orthologs
human all
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Genomic context

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Location:
2 D; 2 49.45 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (84818540..84826903)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (84988196..84996559)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E11144 Neighboring gene STARR-positive B cell enhancer ABC_E2629 Neighboring gene solute carrier family 43, member 3 Neighboring gene STARR-positive B cell enhancer ABC_E7835 Neighboring gene STARR-positive B cell enhancer ABC_E7836 Neighboring gene STARR-positive B cell enhancer ABC_E11145 Neighboring gene predicted gene, 39868 Neighboring gene proteoglycan 2, bone marrow Neighboring gene purinergic receptor P2X, ligand-gated ion channel, 3 Neighboring gene STARR-positive B cell enhancer ABC_E225 Neighboring gene structure specific recognition protein 1 Neighboring gene tankyrase 1 binding protein 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Identification of a new murine eosinophil major basic protein (mMBP) gene: cloning and characterization of mMBP-2. Macias MP, et al. J Leukoc Biol, 2000 Apr. PMID 10770291
  2. The transcription factor XBP1 is selectively required for eosinophil differentiation. Bettigole SE, et al. Nat Immunol, 2015 Aug. PMID 26147683, Free PMC Article
  3. Decreased expression levels of Ifi genes is associated to the increased resistance to spontaneous arthritis disease in mice deficiency of IL-1RA. Liu X, et al. BMC Immunol, 2016 Aug 2. PMID 27480124, Free PMC Article
  4. Nell1-deficient mice have reduced expression of extracellular matrix proteins causing cranial and vertebral defects. Desai J, et al. Hum Mol Genet, 2006 Apr 15. PMID 16537572
  5. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Clone Names

  • MGC129482, MGC129483

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables carbohydrate binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in basophil activation ISO
Inferred from Sequence Orthology
more info
  
involved_in histamine biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in leukotriene biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of translation ISO
Inferred from Sequence Orthology
more info
  
involved_in neutrophil activation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of interleukin-8 production ISO
Inferred from Sequence Orthology
more info
  
involved_in superoxide anion generation ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
proteoglycan 3
Names
eosinophil major basic protein 2
major basic protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_016914.2 → NP_058610.1  proteoglycan 3 precursor

    See identical proteins and their annotated locations for NP_058610.1

    Status: PROVISIONAL

    Source sequence(s)
    AL935159
    Consensus CDS
    CCDS16199.1
    UniProtKB/Swiss-Prot
    A2AW01, Q3SXA9, Q9JL95
    Related
    ENSMUSP00000028466.6, ENSMUST00000028466.12
    Conserved Domains (1) summary
    cd03598
    Location:108 → 222
    CLECT_EMBP_like; C-type lectin-like domain (CTLD) of the type found in the human proteins, eosinophil major basic protein (EMBP) and prepro major basic protein homolog (MBPH)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    84818540..84826903
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036162391.1 → XP_036018284.1  proteoglycan 3 isoform X1

    UniProtKB/Swiss-Prot
    A2AW01, Q3SXA9, Q9JL95
    Conserved Domains (1) summary
    cd03598
    Location:108 → 222
    CLECT_EMBP_like; C-type lectin-like domain (CTLD) of the type found in the human proteins, eosinophil major basic protein (EMBP) and prepro major basic protein homolog (MBPH)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9JL95.1 GenPept UniProtKB/Swiss-Prot:Q9JL95

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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