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C11orf24 chromosome 11 open reading frame 24 [ Homo sapiens (human) ]

Gene ID: 53838, updated on 5-Mar-2024

Summary

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Official Symbol
C11orf24provided by HGNC
Official Full Name
chromosome 11 open reading frame 24provided by HGNC
Primary source
HGNC:HGNC:1174
See related
Ensembl:ENSG00000171067 MIM:610880; AllianceGenome:HGNC:1174
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DM4E3
Summary
Located in Golgi apparatus and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in small intestine (RPKM 25.6), duodenum (RPKM 22.6) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
11q13.2
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (68261338..68271973, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (68264928..68276330, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (68028806..68039441, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:67888828-67889593 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:67889594-67890360 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:67907579-67907779 Neighboring gene CHKA divergent transcript Neighboring gene lysine methyltransferase 5B Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3661 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3662 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:67981441-67982143 Neighboring gene Sharpr-MPRA regulatory region 2086 Neighboring gene MPRA-validated peak1319 silencer Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr11:68034746-68035945 Neighboring gene uncharacterized LOC105369363 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:68039550-68040404 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3666 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5133 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5134 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:68066209-68066956 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:68067706-68068453 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3667 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:68080045-68080920 Neighboring gene uncharacterized LOC124900302 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:68080921-68081795 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:68082507-68083006 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:68084075-68084742 Neighboring gene LDL receptor related protein 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. C11ORF24 is a novel type I membrane protein that cycles between the Golgi apparatus and the plasma membrane in Rab6-positive vesicles. Fraisier V, et al. PLoS One, 2013. PMID 24312644, Free PMC Article
  2. The sequence and gene characterization of a 400-kb candidate region for IDDM4 on chromosome 11q13. Twells RC, et al. Genomics, 2001 Mar 15. PMID 11401438
  3. Large-scale cDNA transfection screening for genes related to cancer development and progression. Wan D, et al. Proc Natl Acad Sci U S A, 2004 Nov 2. PMID 15498874, Free PMC Article
  4. Systematic identification of pathological lamin A interactors. Dittmer TA, et al. Mol Biol Cell, 2014 May. PMID 24623722, Free PMC Article
  5. E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins. Khanna R, et al. FEBS J, 2018 Jun. PMID 29676528

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
  
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
uncharacterized protein C11orf24

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001300913.2 → NP_001287842.1  uncharacterized protein C11orf24 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001287842.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame segment compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AP002813, BC011765, BI862360, BX384793, DB471655
    Consensus CDS
    CCDS73338.1
    UniProtKB/TrEMBL
    E9PRU5

  2. NM_022338.4 → NP_071733.1  uncharacterized protein C11orf24 isoform 1 precursor

    See identical proteins and their annotated locations for NP_071733.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AF264781, BC011765, BG701401
    Consensus CDS
    CCDS8180.1
    UniProtKB/Swiss-Prot
    Q96F05, Q9H2K4
    Related
    ENSP00000307264.6, ENST00000304271.11
    Conserved Domains (1) summary
    PHA03247
    Location:133 → 391
    PHA03247; large tegument protein UL36; Provisional

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    68261338..68271973 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047427129.1 → XP_047283085.1  uncharacterized protein C11orf24 isoform X3

    UniProtKB/TrEMBL
    E9PRU5
    Related
    ENSP00000434144.1, ENST00000533310.5

  2. XM_005274053.5 → XP_005274110.1  uncharacterized protein C11orf24 isoform X1

    See identical proteins and their annotated locations for XP_005274110.1

    UniProtKB/Swiss-Prot
    Q96F05, Q9H2K4
    Conserved Domains (1) summary
    PHA03247
    Location:133 → 391
    PHA03247; large tegument protein UL36; Provisional

  3. XM_011545103.4 → XP_011543405.1  uncharacterized protein C11orf24 isoform X2

    Conserved Domains (1) summary
    PHA03247
    Location:101 → 359
    PHA03247; large tegument protein UL36; Provisional

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    68264928..68276330 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054369136.1 → XP_054225111.1  uncharacterized protein C11orf24 isoform X1

    UniProtKB/Swiss-Prot
    Q96F05, Q9H2K4

  2. XM_054369138.1 → XP_054225113.1  uncharacterized protein C11orf24 isoform X3

    UniProtKB/TrEMBL
    E9PRU5

  3. XM_054369137.1 → XP_054225112.1  uncharacterized protein C11orf24 isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q96F05.2 GenPept UniProtKB/Swiss-Prot:Q96F05

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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