U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Cldn7 claudin 7 [ Mus musculus (house mouse) ]

Gene ID: 53624, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
Cldn7provided by MGI
Official Full Name
claudin 7provided by MGI
Primary source
MGI:MGI:1859285
See related
Ensembl:ENSMUSG00000018569 AllianceGenome:MGI:1859285
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is expressed constitutively in the mammary epithelium throughout development, and might be involved in vesicle trafficking to the basolateral membrane. It is essential for NaCl homeostasis in distal nephrons. The knockout mice lacking this gene showed severe salt wasting, chronic dehydration, and growth retardation, and died within 12 days after birth. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2010]
Expression
Biased expression in large intestine adult (RPKM 431.6), small intestine adult (RPKM 310.8) and 4 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
11 B3; 11 42.94 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (69855605..69858712)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (69964779..69967886)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 2 (facilitated glucose transporter), member 4 Neighboring gene STARR-positive B cell enhancer ABC_E9140 Neighboring gene cofilin 1, non-muscle pseudogene Neighboring gene elongator acetyltransferase complex subunit 5 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:69793405-69793588 Neighboring gene STARR-positive B cell enhancer ABC_E3967 Neighboring gene CTD nuclear envelope phosphatase 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:69804503-69804686 Neighboring gene STARR-positive B cell enhancer ABC_E2997 Neighboring gene gamma-aminobutyric acid receptor associated protein

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Intestinal Claudin-7 deficiency impacts the intestinal microbiota in mice with colitis. Ding Y, et al. BMC Gastroenterol, 2022 Jan 17. PMID 35039003, Free PMC Article
  2. Upregulation of Claudin-7 Expression by Angiotensin II in Colonic Epithelial Cells of Mice Fed with NaCl-Depleted Diets. Takashina Y, et al. Int J Mol Sci, 2020 Feb 20. PMID 32093310, Free PMC Article
  3. Tight Junction Protein Claudin-7 Is Essential for Intestinal Epithelial Stem Cell Self-Renewal and Differentiation. Xing T, et al. Cell Mol Gastroenterol Hepatol, 2020. PMID 31874254, Free PMC Article
  4. Claudin-7 gene knockout causes destruction of intestinal structure and animal death in mice. Xu C, et al. World J Gastroenterol, 2019 Feb 7. PMID 30774273, Free PMC Article
  5. Severe Intestinal Inflammation in the Small Intestine of Mice Induced by Controllable Deletion of Claudin-7. Li WJ, et al. Dig Dis Sci, 2018 May. PMID 29488037, Free PMC Article

See all (73) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Intestinal Claudin-7 deficiency impacts the intestinal microbiota in mice with colitis.
    Title: Intestinal Claudin-7 deficiency impacts the intestinal microbiota in mice with colitis.
  2. Tight Junction Protein Claudin-7 Is Essential for Intestinal Epithelial Stem Cell Self-Renewal and Differentiation.
    Title: Tight Junction Protein Claudin-7 Is Essential for Intestinal Epithelial Stem Cell Self-Renewal and Differentiation.
  3. Upregulation of Claudin-7 Expression by Angiotensin II in Colonic Epithelial Cells of Mice Fed with NaCl-Depleted Diets.
    Title: Upregulation of Claudin-7 Expression by Angiotensin II in Colonic Epithelial Cells of Mice Fed with NaCl-Depleted Diets.
  4. This study demonstrates that CLDN7 plays an important role in salt balance in renal CD cells and modulating WNK4 and ENaC expression levels that are vital in controlling salt-sensitive hypertension.
    Title: Claudin-7 Modulates Cl(-) and Na(+) Homeostasis and WNK4 Expression in Renal Collecting Duct Cells.
  5. The knockout of Claudin-7 in vivo causes extensive inflammation, atypical hyperplasia, and adenoma in intestinal tissue as well as animal death in mice. Claudin-7 may act as a tumor suppressor gene in the development of colorectal cancer.
    Title: Claudin-7 gene knockout causes destruction of intestinal structure and animal death in mice.
  6. Intestinal Cldn7 deletion initiated inflammation and hyperplasia in mice.
    Title: Severe Intestinal Inflammation in the Small Intestine of Mice Induced by Controllable Deletion of Claudin-7.
  7. These results identify EpCAM as a substrate of matriptase and link HAI-2, matriptase, EpCAM, and claudin-7 in a functionally important pathway that causes disease when it is dysregulated.
    Title: Matriptase-mediated cleavage of EpCAM destabilizes claudins and dysregulates intestinal epithelial homeostasis.
  8. role in post-natal mammary gland development and the formation of cell junctions
    Title: Connexins, E-cadherin, Claudin-7 and β-catenin transiently form junctional nexuses during the post-natal mammary gland development.
  9. localization of Cldn3, Cldn7 and Cldn10 proteins in the different compartments of murine endometrium up to day 8.5 of pregnancy (dpc) as well as in human endometrium and first trimester decidua
    Title: Claudin-3, claudin-7, and claudin-10 show different distribution patterns during decidualization and trophoblast invasion in mouse and human.
  10. Data show that claudin-4 and claudin-7 were observed in hepatocytes of severely damaged mouse and human livers.
    Title: Aberrant expression of claudin-4 and -7 in hepatocytes in the cirrhotic human liver.
Submit: New GeneRIF Correction See all GeneRIFs (18)

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (2) 

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cell adhesion molecule binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein domain specific binding ISO
Inferred from Sequence Orthology
more info
  
enables structural molecule activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in bicellular tight junction assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cell adhesion ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of protein-containing complex assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cell motility ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in anchoring junction IEA
Inferred from Electronic Annotation
more info
  
located_in apicolateral plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in basolateral plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in basolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in bicellular tight junction IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in bicellular tight junction IDA
Inferred from Direct Assay
more info
 PubMed 
located_in lateral plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in lateral plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in membrane NAS
Non-traceable Author Statement
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
claudin-7

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001193619.1 → NP_001180548.1  claudin-7

    See identical proteins and their annotated locations for NP_001180548.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) has an alternate 5' UTR, as compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AL596185
    Consensus CDS
    CCDS24925.1
    UniProtKB/Swiss-Prot
    Q3TJX4, Q9Z261
    Related
    ENSMUSP00000104238.2, ENSMUST00000108597.8
    Conserved Domains (1) summary
    pfam00822
    Location:4 → 171
    PMP22_Claudin; PMP-22/EMP/MP20/Claudin family

  2. NM_016887.6 → NP_058583.1  claudin-7

    See identical proteins and their annotated locations for NP_058583.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) and variant 2 encode the same protein.
    Source sequence(s)
    AK145504, BG083098
    Consensus CDS
    CCDS24925.1
    UniProtKB/Swiss-Prot
    Q3TJX4, Q9Z261
    Related
    ENSMUSP00000018713.7, ENSMUST00000018713.13
    Conserved Domains (1) summary
    pfam00822
    Location:4 → 171
    PMP22_Claudin; PMP-22/EMP/MP20/Claudin family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    69855605..69858712
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Z261.1 GenPept UniProtKB/Swiss-Prot:Q9Z261

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous