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Vamp5 vesicle-associated membrane protein 5 [ Mus musculus (house mouse) ]

Gene ID: 53620, updated on 5-Mar-2024

Summary

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Official Symbol
Vamp5provided by MGI
Official Full Name
vesicle-associated membrane protein 5provided by MGI
Primary source
MGI:MGI:1858622
See related
Ensembl:ENSMUSG00000073002 AllianceGenome:MGI:1858622
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Camp
Summary
Acts upstream of or within Golgi to plasma membrane protein transport and skeletal muscle tissue development. Located in several cellular components, including cytoplasmic vesicle; intercalated disc; and perinuclear region of cytoplasm. Is integral component of organelle membrane and integral component of plasma membrane. Orthologous to human VAMP5 (vesicle associated membrane protein 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in liver E14.5 (RPKM 12.4), liver E14 (RPKM 12.0) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
6 C1; 6 32.27 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (72345032..72357451, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (72368049..72380468, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 0610030E20 gene Neighboring gene transmembrane protein 150A Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:72312603-72312712 Neighboring gene ring finger protein 181 Neighboring gene predicted gene, 52494 Neighboring gene vesicle-associated membrane protein 8 Neighboring gene STARR-positive B cell enhancer ABC_E10385 Neighboring gene STARR-positive B cell enhancer ABC_E2789 Neighboring gene gamma-glutamyl carboxylase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Loss of VAMP5 in mice results in duplication of the ureter and insufficient expansion of the lung. Ikezawa M, et al. Dev Dyn, 2018 May. PMID 29330887
  2. The localization of VAMP5 in skeletal and cardiac muscle. Takahashi M, et al. Histochem Cell Biol, 2013 Apr. PMID 23180306
  3. A novel synaptobrevin/VAMP homologous protein (VAMP5) is increased during in vitro myogenesis and present in the plasma membrane. Zeng Q, et al. Mol Biol Cell, 1998 Sep. PMID 9725904, Free PMC Article
  4. The cytoplasmic domain of Vamp4 and Vamp5 is responsible for their correct subcellular targeting: the N-terminal extenSion of VAMP4 contains a dominant autonomous targeting signal for the trans-Golgi network. Zeng Q, et al. J Biol Chem, 2003 Jun 20. PMID 12682051
  5. Requirement for distinct vesicle-associated membrane proteins in insulin- and AMP-activated protein kinase (AMPK)-induced translocation of GLUT4 and CD36 in cultured cardiomyocytes. Schwenk RW, et al. Diabetologia, 2010 Oct. PMID 20582536, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. VAMP5 promotes Fcgamma receptor-mediated phagocytosis and regulates phagosome maturation in macrophages.
    Title: VAMP5 promotes Fcγ receptor-mediated phagocytosis and regulates phagosome maturation in macrophages.
  2. Loss of VAMP5 in mice results in duplication of the ureter and insufficient expansion of the lung
    Title: Loss of VAMP5 in mice results in duplication of the ureter and insufficient expansion of the lung.
  3. study found that VAMP5 was expressed in the type IIa fibers of skeletal muscle and that in cardiomyocytes, VAMP5 expression was localized to the vicinity of intercalated discs
    Title: The localization of VAMP5 in skeletal and cardiac muscle.
  4. The cytoplasmic domain of this protein is responsible for its correct subcellular targeting.
    Title: The cytoplasmic domain of Vamp4 and Vamp5 is responsible for their correct subcellular targeting: the N-terminal extenSion of VAMP4 contains a dominant autonomous targeting signal for the trans-Golgi network.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in Golgi to plasma membrane protein transport IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within Golgi to plasma membrane protein transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within muscle organ development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within skeletal muscle tissue development IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in cell surface ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasmic vesicle membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in intercalated disc IDA
Inferred from Direct Assay
more info
 PubMed 
located_in late endosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in organelle membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in trans-Golgi network ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
vesicle-associated membrane protein 5
Names
VAMP-5
myobrevin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001080742.2 → NP_001074211.1  vesicle-associated membrane protein 5

    See identical proteins and their annotated locations for NP_001074211.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC116115, AK009266
    Consensus CDS
    CCDS39513.1
    UniProtKB/Swiss-Prot
    Q9Z2P8
    UniProtKB/TrEMBL
    Q5M9K2, Q791P0
    Related
    ENSMUSP00000073852.4, ENSMUST00000074231.6
    Conserved Domains (2) summary
    cd15872
    Location:5 → 70
    R-SNARE_VAMP5; SNARE motif of VAMP5
    pfam00957
    Location:4 → 79
    Synaptobrevin; Synaptobrevin

  2. NM_016872.4 → NP_058568.1  vesicle-associated membrane protein 5

    See identical proteins and their annotated locations for NP_058568.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC116115, BC086925
    Consensus CDS
    CCDS39513.1
    UniProtKB/Swiss-Prot
    Q9Z2P8
    UniProtKB/TrEMBL
    Q5M9K2, Q791P0
    Related
    ENSMUSP00000098843.4, ENSMUST00000101285.10
    Conserved Domains (2) summary
    cd15872
    Location:5 → 70
    R-SNARE_VAMP5; SNARE motif of VAMP5
    pfam00957
    Location:4 → 79
    Synaptobrevin; Synaptobrevin

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    72345032..72357451 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Z2P8.1 GenPept UniProtKB/Swiss-Prot:Q9Z2P8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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