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ADAM22 ADAM metallopeptidase domain 22 [ Homo sapiens (human) ]

Gene ID: 53616, updated on 16-Apr-2024

Summary

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Official Symbol
ADAM22provided by HGNC
Official Full Name
ADAM metallopeptidase domain 22provided by HGNC
Primary source
HGNC:HGNC:201
See related
Ensembl:ENSG00000008277 MIM:603709; AllianceGenome:HGNC:201
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MDC2; DEE61; EIEE61; ADAM 22
Summary
This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. Unlike other members of the ADAM protein family, the protein encoded by this gene lacks metalloprotease activity since it has no zinc-binding motif. This gene is highly expressed in the brain and may function as an integrin ligand in the brain. In mice, it has been shown to be essential for correct myelination in the peripheral nervous system. Alternative splicing results in several transcript variants.[provided by RefSeq, Dec 2010]
Expression
Biased expression in brain (RPKM 9.0), adrenal (RPKM 2.5) and 10 other tissues See more
Orthologs
mouse all
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Genomic context

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See ADAM22 in Genome Data Viewer
Location:
7q21.12
Exon count:
35
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (87934251..88202889)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (89184170..89453378)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (87563566..87832204)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene origin of replication in promoter of DBF4 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:87505271-87505780 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26234 Neighboring gene uncharacterized LOC124901690 Neighboring gene DBF4-CDC7 kinase regulatory subunit Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:87556085-87556653 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18354 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:87563985-87564562 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:87564563-87565140 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:87584727-87585228 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:87663457-87663957 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26238 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26239 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26240 Neighboring gene uncharacterized LOC105375386 Neighboring gene MPRA-validated peak6626 silencer Neighboring gene uncharacterized LOC124901691 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18355 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18356 Neighboring gene Sharpr-MPRA regulatory region 10982 Neighboring gene SRI antisense RNA 1 Neighboring gene sorcin

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Biallelic ADAM22 pathogenic variants cause progressive encephalopathy and infantile-onset refractory epilepsy. van der Knoop MM, et al. Brain, 2022 Jul 29. PMID 35373813, Free PMC Article
  2. ADAM22 as a prognostic and therapeutic drug target in the treatment of endocrine-resistant breast cancer. Bolger JC, et al. Vitam Horm, 2013. PMID 23810013
  3. Biological characterization of ADAM22 variants reveals the importance of a disintegrin domain sequence in cell surface expression. Sagane K, et al. J Recept Signal Transduct Res, 2010 Apr. PMID 20156119
  4. Expression, purification and insights into structure and folding of the ADAM22 pro domain. Sørensen HP, et al. Protein Expr Purif, 2008 Oct. PMID 18593599
  5. Autosomal dominant lateral temporal epilepsy: absence of mutations in ADAM22 and Kv1 channel genes encoding LGI1-associated proteins. Diani E, et al. Epilepsy Res, 2008 Jul. PMID 18440780

See all (48) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ADAM22 acts as a novel predictive biomarker for unfavorable prognosis and facilitates metastasis via PI3K/AKT signaling pathway in nasopharyngeal carcinoma.
    Title: ADAM22 acts as a novel predictive biomarker for unfavorable prognosis and facilitates metastasis via PI3K/AKT signaling pathway in nasopharyngeal carcinoma.
  2. Biallelic ADAM22 pathogenic variants cause progressive encephalopathy and infantile-onset refractory epilepsy.
    Title: Biallelic ADAM22 pathogenic variants cause progressive encephalopathy and infantile-onset refractory epilepsy.
  3. LGI3 is secreted and binds to ADAM22 via TRIF-dependent NF-kappaB pathway in response to LPS in human keratinocytes.
    Title: LGI3 is secreted and binds to ADAM22 via TRIF-dependent NF-κB pathway in response to LPS in human keratinocytes.
  4. ADAM22/LGI1 complex as a new actionable target for breast cancer brain metastasis.
    Title: ADAM22/LGI1 complex as a new actionable target for breast cancer brain metastasis.
  5. the LGI1-ADAM22 complex functions as the trans-synaptic machinery for precise synaptic transmission
    Title: Structural basis of epilepsy-related ligand-receptor complex LGI1-ADAM22.
  6. ADAM22 is critically involved in miR-449a-reduced tamoxifen resistance of estrogen receptor-positive breast cancer cells as a direct target of miR-449a.
    Title: miR-449a Suppresses Tamoxifen Resistance in Human Breast Cancer Cells by Targeting ADAM22.
  7. these results support the existence of a second mechanism, alternative to inhibition of protein secretion, by which ADLTE-causing LGI1 mutations exert their loss-of-function effect extracellularly, and suggest that interactions of LGI1 with both ADAM22 and ADAM23 play an important role in the molecular mechanisms leading to utosomal dominant lateral temporal epilepsy
    Title: Secretion-Positive LGI1 Mutations Linked to Lateral Temporal Epilepsy Impair Binding to ADAM22 and ADAM23 Receptors.
  8. Disruption of LGI1-ADAM22 interaction reduces synaptic AMPA receptors in hippocampal neurons.
    Title: Autoantibodies to epilepsy-related LGI1 in limbic encephalitis neutralize LGI1-ADAM22 interaction and reduce synaptic AMPA receptors.
  9. Data suggest that ADAM22 plays roles in cell differentiation, cell migration, and resistance to endocrine therapy in breast cancer; ADAM22 may serve as biomarker for poor disease-free survival in breast cancer patients. [REVIEW]
    Title: ADAM22 as a prognostic and therapeutic drug target in the treatment of endocrine-resistant breast cancer.
  10. findings suggest that SRC-1 switches steroid-responsive tumors to a steroid-resistant state in which the SRC-1 target gene ADAM22 has a critical role
    Title: Global characterization of the SRC-1 transcriptome identifies ADAM22 as an ER-independent mediator of endocrine-resistant breast cancer.
Submit: New GeneRIF Correction See all GeneRIFs (21)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Developmental and epileptic encephalopathy, 61
MedGen: C4693688 OMIM: 617933 GeneReviews: Not available
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EBI GWAS Catalog

Description
Genome-wide association study of serious blistering skin rash caused by drugs.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC149832

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables integrin binding NAS
Non-traceable Author Statement
more info
 PubMed 
enables metalloendopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell adhesion IEA
Inferred from Electronic Annotation
more info
  
involved_in central nervous system development TAS
Traceable Author Statement
more info
 PubMed 
involved_in negative regulation of cell adhesion NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in axon ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in membrane NAS
Non-traceable Author Statement
more info
 PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
  
is_active_in postsynaptic density membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
disintegrin and metalloproteinase domain-containing protein 22
Names
a disintegrin and metalloproteinase domain 22
metalloproteinase-disintegrin ADAM22-3
metalloproteinase-like, disintegrin-like, and cysteine-rich protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001324417.2 → NP_001311346.1  disintegrin and metalloproteinase domain-containing protein 22 isoform 6 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) encodes isoform 6. The encoded isoform (6) may undergo proteolytic processing.
    Source sequence(s)
    AC004992, AC005075, AC005164, DR000609, R41888
    UniProtKB/TrEMBL
    Q08AL8

  2. NM_001324418.2 → NP_001311347.1  disintegrin and metalloproteinase domain-containing protein 22 isoform 7 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) encodes isoform 7. The encoded isoform (7) may undergo proteolytic processing.
    Source sequence(s)
    AC004992, AC005075, AC005164, DR000609, R41888
    Consensus CDS
    CCDS94137.1
    UniProtKB/TrEMBL
    A0A804HHS1, H7C3I4
    Related
    ENSP00000412085.2, ENST00000413139.2

  3. NM_001324419.2 → NP_001311348.1  disintegrin and metalloproteinase domain-containing protein 22 isoform 8 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) encodes isoform 8. The encoded isoform (8) may undergo proteolytic processing.
    Source sequence(s)
    AC004992, AC005075, AC005164, DR000609, R41888
    UniProtKB/TrEMBL
    A0A804HHS1

  4. NM_001324420.2 → NP_001311349.1  disintegrin and metalloproteinase domain-containing protein 22 isoform 9 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) encodes isoform 9. The encoded isoform (9) may undergo proteolytic processing.
    Source sequence(s)
    AC004992, AC005075, AC005164, DR000609, R41888
    UniProtKB/TrEMBL
    A0A804HHS1

  5. NM_001324421.2 → NP_001311350.1  disintegrin and metalloproteinase domain-containing protein 22 isoform 10 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10) encodes isoform 10. The encoded isoform (10) may undergo proteolytic processing.
    Source sequence(s)
    AC004992, AC005075, AC005164, DR000609, R41888
    UniProtKB/TrEMBL
    Q08AL8

  6. NM_001391975.1 → NP_001378904.1  disintegrin and metalloproteinase domain-containing protein 22 isoform 11 precursor

    Status: REVIEWED

    Source sequence(s)
    AC004992, AC005075, AC005164
    UniProtKB/TrEMBL
    Q08AL8
    Conserved Domains (4) summary
    smart00050
    Location:470 → 545
    DISIN; Homologues of snake disintegrins
    smart00608
    Location:547 → 688
    ACR; ADAM Cysteine-Rich Domain
    pfam01421
    Location:256 → 455
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:102 → 205
    Pep_M12B_propep; Reprolysin family propeptide

  7. NM_001391976.1 → NP_001378905.1  disintegrin and metalloproteinase domain-containing protein 22 isoform 12 precursor

    Status: REVIEWED

    Source sequence(s)
    AC004992, AC005075, AC005164
    UniProtKB/TrEMBL
    Q08AL8
    Conserved Domains (4) summary
    smart00050
    Location:453 → 528
    DISIN; Homologues of snake disintegrins
    smart00608
    Location:530 → 671
    ACR; ADAM Cysteine-Rich Domain
    pfam01421
    Location:239 → 438
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:71 → 188
    Pep_M12B_propep; Reprolysin family propeptide

  8. NM_001391977.1 → NP_001378906.1  disintegrin and metalloproteinase domain-containing protein 22 isoform 13 precursor

    Status: REVIEWED

    Source sequence(s)
    AC004992, AC005075, AC005164
    UniProtKB/TrEMBL
    Q08AL8
    Conserved Domains (4) summary
    smart00050
    Location:453 → 528
    DISIN; Homologues of snake disintegrins
    smart00608
    Location:530 → 671
    ACR; ADAM Cysteine-Rich Domain
    pfam01421
    Location:239 → 438
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:71 → 188
    Pep_M12B_propep; Reprolysin family propeptide

  9. NM_001391978.1 → NP_001378907.1  disintegrin and metalloproteinase domain-containing protein 22 isoform 14 precursor

    Status: REVIEWED

    Source sequence(s)
    AC004992, AC005075, AC005164
    UniProtKB/TrEMBL
    Q08AL8
    Conserved Domains (4) summary
    smart00050
    Location:452 → 527
    DISIN; Homologues of snake disintegrins
    smart00608
    Location:529 → 670
    ACR; ADAM Cysteine-Rich Domain
    pfam01421
    Location:238 → 437
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:70 → 187
    Pep_M12B_propep; Reprolysin family propeptide

  10. NM_001391979.1 → NP_001378908.1  disintegrin and metalloproteinase domain-containing protein 22 isoform 15 precursor

    Status: REVIEWED

    Source sequence(s)
    AC004992, AC005075, AC005164
    UniProtKB/TrEMBL
    Q08AL8
    Conserved Domains (4) summary
    smart00050
    Location:452 → 527
    DISIN; Homologues of snake disintegrins
    smart00608
    Location:529 → 670
    ACR; ADAM Cysteine-Rich Domain
    pfam01421
    Location:238 → 437
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:70 → 187
    Pep_M12B_propep; Reprolysin family propeptide

  11. NM_001391980.1 → NP_001378909.1  disintegrin and metalloproteinase domain-containing protein 22 isoform 16 precursor

    Status: REVIEWED

    Source sequence(s)
    AC004992, AC005075, AC005164
    UniProtKB/TrEMBL
    Q08AL8
    Conserved Domains (4) summary
    smart00050
    Location:470 → 545
    DISIN; Homologues of snake disintegrins
    smart00608
    Location:547 → 688
    ACR; ADAM Cysteine-Rich Domain
    pfam01421
    Location:256 → 455
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:102 → 205
    Pep_M12B_propep; Reprolysin family propeptide

  12. NM_001391981.1 → NP_001378910.1  disintegrin and metalloproteinase domain-containing protein 22 isoform 17 precursor

    Status: REVIEWED

    Source sequence(s)
    AC004992, AC005075, AC005164
    UniProtKB/TrEMBL
    Q08AL8
    Conserved Domains (4) summary
    smart00050
    Location:452 → 527
    DISIN; Homologues of snake disintegrins
    smart00608
    Location:529 → 670
    ACR; ADAM Cysteine-Rich Domain
    pfam01421
    Location:238 → 437
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:70 → 187
    Pep_M12B_propep; Reprolysin family propeptide

  13. NM_001391982.1 → NP_001378911.1  disintegrin and metalloproteinase domain-containing protein 22 isoform 18 precursor

    Status: REVIEWED

    Source sequence(s)
    AC004992, AC005075, AC005164
    UniProtKB/TrEMBL
    Q08AL8
    Conserved Domains (4) summary
    smart00050
    Location:445 → 520
    DISIN; Homologues of snake disintegrins
    smart00608
    Location:522 → 663
    ACR; ADAM Cysteine-Rich Domain
    pfam01421
    Location:241 → 430
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:102 → 205
    Pep_M12B_propep; Reprolysin family propeptide

  14. NM_004194.5 → NP_004185.1  disintegrin and metalloproteinase domain-containing protein 22 isoform 4 precursor

    See identical proteins and their annotated locations for NP_004185.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4), also known as beta, uses an alternate splice site in the 3' coding region and lacks two downstream exons, compared to variant 1. The resulting protein (isoform 4) has a shorter and distinct C-terminus, compared to isoform 1. The encoded isoform (4) may undergo proteolytic processing.
    Source sequence(s)
    AB009671, AC005075, DR000609
    Consensus CDS
    CCDS43610.1
    UniProtKB/TrEMBL
    A0A804HHS1
    Related
    ENSP00000381260.4, ENST00000398201.8
    Conserved Domains (5) summary
    smart00608
    Location:530 → 671
    ACR; ADAM Cysteine-Rich Domain
    cd04269
    Location:239 → 436
    ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
    pfam00200
    Location:453 → 527
    Disintegrin; Disintegrin
    pfam01421
    Location:239 → 438
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:75 → 187
    Pep_M12B_propep; Reprolysin family propeptide

  15. NM_016351.6 → NP_057435.2  disintegrin and metalloproteinase domain-containing protein 22 isoform 3 precursor

    See identical proteins and their annotated locations for NP_057435.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3), also known as alpha, lacks an in-frame exon compared to variant 1. The encoded isoform (3) is shorter than isoform 1. The encoded isoform (3) may undergo proteolytic processing.
    Source sequence(s)
    AC005075, AC005164, AK291010, DR000609, R41888
    Consensus CDS
    CCDS43609.1
    UniProtKB/TrEMBL
    Q08AL8
    Related
    ENSP00000381262.4, ENST00000398204.8
    Conserved Domains (5) summary
    smart00608
    Location:530 → 671
    ACR; ADAM Cysteine-Rich Domain
    cd04269
    Location:239 → 436
    ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
    pfam00200
    Location:453 → 527
    Disintegrin; Disintegrin
    pfam01421
    Location:239 → 438
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:75 → 187
    Pep_M12B_propep; Reprolysin family propeptide

  16. NM_021721.5 → NP_068367.1  disintegrin and metalloproteinase domain-containing protein 22 isoform 5 precursor

    See identical proteins and their annotated locations for NP_068367.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) uses an alternate splice site in the 3' coding region and lacks one coding and two non-coding exons, compared to variant 1. The resulting protein (isoform 5) has a shorter and distinct C-terminus, compared to isoform 1. The encoded isoform (5) may undergo proteolytic processing.
    Source sequence(s)
    AB009671, AC005075, AF155381, DR000609
    Consensus CDS
    CCDS94138.1
    UniProtKB/TrEMBL
    Q08AL8
    Related
    ENSP00000508320.1, ENST00000684002.1
    Conserved Domains (5) summary
    smart00608
    Location:530 → 671
    ACR; ADAM Cysteine-Rich Domain
    cd04269
    Location:239 → 436
    ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
    pfam00200
    Location:453 → 527
    Disintegrin; Disintegrin
    pfam01421
    Location:239 → 438
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:75 → 187
    Pep_M12B_propep; Reprolysin family propeptide

  17. NM_021722.6 → NP_068368.2  disintegrin and metalloproteinase domain-containing protein 22 isoform 2 precursor

    See identical proteins and their annotated locations for NP_068368.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2), also known as delta, has multiple differences in the coding region but maintains the reading frame, compared to variant 1. The encoded isoform (2) is shorter than isoform 1. The encoded isoform (2) may undergo proteolytic processing.
    Source sequence(s)
    AC005075, AF155381, DR000609, R41888
    Consensus CDS
    CCDS43608.1
    UniProtKB/TrEMBL
    Q08AL8
    Related
    ENSP00000381267.3, ENST00000398209.7
    Conserved Domains (5) summary
    smart00608
    Location:530 → 671
    ACR; ADAM Cysteine-Rich Domain
    cd04269
    Location:239 → 436
    ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
    pfam00200
    Location:453 → 527
    Disintegrin; Disintegrin
    pfam01421
    Location:239 → 438
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:75 → 187
    Pep_M12B_propep; Reprolysin family propeptide

  18. NM_021723.5 → NP_068369.1  disintegrin and metalloproteinase domain-containing protein 22 isoform 1 preproprotein

    See identical proteins and their annotated locations for NP_068369.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1), also known as epsilon, encodes isoform 1, which is proteolytically processed to generate the mature protein.
    Source sequence(s)
    AC005075, AF155382, DR000609, R41888
    Consensus CDS
    CCDS47637.1
    UniProtKB/Swiss-Prot
    O75075, O75076, Q9P0K1, Q9P0K2, Q9UIA1, Q9UKK2
    UniProtKB/TrEMBL
    Q08AL8
    Related
    ENSP00000265727.7, ENST00000265727.11
    Conserved Domains (5) summary
    smart00608
    Location:530 → 671
    ACR; ADAM Cysteine-Rich Domain
    cd04269
    Location:239 → 436
    ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
    pfam00200
    Location:453 → 527
    Disintegrin; Disintegrin
    pfam01421
    Location:239 → 438
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:75 → 187
    Pep_M12B_propep; Reprolysin family propeptide

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    87934251..88202889
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017012330.3 → XP_016867819.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X9

    UniProtKB/TrEMBL
    A0A804HHS1

  2. XM_017012335.3 → XP_016867824.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X14

    UniProtKB/TrEMBL
    Q08AL8

  3. XM_011516318.3 → XP_011514620.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X2

    UniProtKB/TrEMBL
    A0A804HHS1
    Conserved Domains (5) summary
    smart00608
    Location:530 → 671
    ACR; ADAM Cysteine-Rich Domain
    cd04269
    Location:239 → 436
    ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
    pfam00200
    Location:453 → 527
    Disintegrin; Disintegrin
    pfam01421
    Location:239 → 438
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:75 → 187
    Pep_M12B_propep; Reprolysin family propeptide

  4. XM_011516322.3 → XP_011514624.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X7

    UniProtKB/TrEMBL
    Q08AL8
    Conserved Domains (5) summary
    smart00608
    Location:530 → 671
    ACR; ADAM Cysteine-Rich Domain
    cd04269
    Location:239 → 436
    ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
    pfam00200
    Location:453 → 527
    Disintegrin; Disintegrin
    pfam01421
    Location:239 → 438
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:75 → 187
    Pep_M12B_propep; Reprolysin family propeptide

  5. XM_017012332.3 → XP_016867821.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X11

    UniProtKB/TrEMBL
    Q08AL8

  6. XM_017012333.3 → XP_016867822.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X13

    UniProtKB/TrEMBL
    A0A804HHS1

  7. XM_011516323.3 → XP_011514625.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X10

    UniProtKB/TrEMBL
    Q08AL8
    Conserved Domains (5) summary
    smart00608
    Location:530 → 671
    ACR; ADAM Cysteine-Rich Domain
    cd04269
    Location:239 → 436
    ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
    pfam00200
    Location:453 → 527
    Disintegrin; Disintegrin
    pfam01421
    Location:239 → 438
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:75 → 187
    Pep_M12B_propep; Reprolysin family propeptide

  8. XM_011516319.4 → XP_011514621.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X3

    UniProtKB/TrEMBL
    A0A804HHS1
    Conserved Domains (5) summary
    smart00608
    Location:529 → 670
    ACR; ADAM Cysteine-Rich Domain
    cd04269
    Location:238 → 435
    ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
    pfam00200
    Location:452 → 526
    Disintegrin; Disintegrin
    pfam01421
    Location:238 → 437
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:74 → 186
    Pep_M12B_propep; Reprolysin family propeptide

  9. XM_006716028.5 → XP_006716091.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X1

    UniProtKB/TrEMBL
    B3KWN4
    Conserved Domains (5) summary
    smart00608
    Location:582 → 723
    ACR; ADAM Cysteine-Rich Domain
    cd04269
    Location:291 → 488
    ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
    pfam00200
    Location:505 → 579
    Disintegrin; Disintegrin
    pfam01421
    Location:291 → 490
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:127 → 239
    Pep_M12B_propep; Reprolysin family propeptide

  10. XM_011516320.4 → XP_011514622.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X4

    UniProtKB/TrEMBL
    B3KWN4
    Conserved Domains (5) summary
    smart00608
    Location:582 → 723
    ACR; ADAM Cysteine-Rich Domain
    cd04269
    Location:291 → 488
    ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
    pfam00200
    Location:505 → 579
    Disintegrin; Disintegrin
    pfam01421
    Location:291 → 490
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:127 → 239
    Pep_M12B_propep; Reprolysin family propeptide

  11. XM_011516321.4 → XP_011514623.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X5

    UniProtKB/TrEMBL
    B3KWN4
    Conserved Domains (5) summary
    smart00608
    Location:582 → 723
    ACR; ADAM Cysteine-Rich Domain
    cd04269
    Location:291 → 488
    ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
    pfam00200
    Location:505 → 579
    Disintegrin; Disintegrin
    pfam01421
    Location:291 → 490
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:127 → 239
    Pep_M12B_propep; Reprolysin family propeptide

  12. XM_005250445.5 → XP_005250502.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X8

    UniProtKB/TrEMBL
    B3KWN4
    Conserved Domains (5) summary
    smart00608
    Location:582 → 723
    ACR; ADAM Cysteine-Rich Domain
    cd04269
    Location:291 → 488
    ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
    pfam00200
    Location:505 → 579
    Disintegrin; Disintegrin
    pfam01421
    Location:291 → 490
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:127 → 239
    Pep_M12B_propep; Reprolysin family propeptide

  13. XM_006716029.5 → XP_006716092.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X6

    UniProtKB/TrEMBL
    B3KWN4
    Conserved Domains (5) summary
    smart00608
    Location:582 → 723
    ACR; ADAM Cysteine-Rich Domain
    cd04269
    Location:291 → 488
    ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
    pfam00200
    Location:505 → 579
    Disintegrin; Disintegrin
    pfam01421
    Location:291 → 490
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:127 → 239
    Pep_M12B_propep; Reprolysin family propeptide

  14. XM_011516324.3 → XP_011514626.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X12

    UniProtKB/TrEMBL
    A0A804HHS1
    Conserved Domains (5) summary
    smart00608
    Location:456 → 597
    ACR; ADAM Cysteine-Rich Domain
    cd04269
    Location:165 → 362
    ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
    pfam00200
    Location:379 → 453
    Disintegrin; Disintegrin
    pfam01421
    Location:165 → 364
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:8 → 113
    Pep_M12B_propep; Reprolysin family propeptide

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    89184170..89453378
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054358425.1 → XP_054214400.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X9

  2. XM_054358430.1 → XP_054214405.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X14

  3. XM_054358418.1 → XP_054214393.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X2

  4. XM_054358423.1 → XP_054214398.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X7

  5. XM_054358427.1 → XP_054214402.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X11

  6. XM_054358429.1 → XP_054214404.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X13

  7. XM_054358426.1 → XP_054214401.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X10

  8. XM_054358419.1 → XP_054214394.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X3

  9. XM_054358417.1 → XP_054214392.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X1

  10. XM_054358420.1 → XP_054214395.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X4

  11. XM_054358421.1 → XP_054214396.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X5

  12. XM_054358424.1 → XP_054214399.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X8

  13. XM_054358422.1 → XP_054214397.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X6

  14. XM_054358428.1 → XP_054214403.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X12

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9P0K1.1 GenPept UniProtKB/Swiss-Prot:Q9P0K1

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