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Hpcal1 hippocalcin-like 1 [ Mus musculus (house mouse) ]

Gene ID: 53602, updated on 11-Apr-2024

Summary

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Official Symbol
Hpcal1provided by MGI
Official Full Name
hippocalcin-like 1provided by MGI
Primary source
MGI:MGI:1855689
See related
Ensembl:ENSMUSG00000071379 AllianceGenome:MGI:1855689
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Nvp3; NVL-3; NVP-3; Vnsl3; Vsnl3; VILIP3
Summary
Predicted to enable calcium ion binding activity. Predicted to be located in membrane. Is expressed in several structures, including central nervous system; ganglia; and retina layer. Orthologous to human HPCAL1 (hippocalcin like 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in cerebellum adult (RPKM 64.1), lung adult (RPKM 42.5) and 27 other tissues See more
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Genomic context

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Location:
12 A1.2; 12 8.13 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (17740810..17841943)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (17690750..17791944)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 36862 Neighboring gene predicted gene, 29864 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:17733384-17733567 Neighboring gene STARR-seq mESC enhancer starr_31667 Neighboring gene predicted gene, 51995 Neighboring gene STARR-seq mESC enhancer starr_31670 Neighboring gene predicted gene, 40312 Neighboring gene STARR-seq mESC enhancer starr_31671 Neighboring gene predicted gene 9222 Neighboring gene predicted gene, 51520

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Hippocalcin-Like 1 blunts liver lipid metabolism to suppress tumorigenesis via directly targeting RUVBL1-mTOR signaling. Chen T, et al. Theranostics, 2022. PMID 36438486, Free PMC Article
  2. Neuronal calcium sensor protein visinin-like protein-3 interacts with microsomal cytochrome b5 in a Ca2+-dependent manner. Oikawa K, et al. J Biol Chem, 2004 Apr 9. PMID 14739275
  3. The periphilin 1-like BFAR isoform 3 is highly expressed in transcriptionally silent oocytes and involved in RNA metabolism. Mrowiec K, et al. Biochim Biophys Acta Mol Cell Res, 2021 Sep. PMID 34175335
  4. DNA microarray analysis of genes involved in p53 mediated apoptosis: activation of Apaf-1. Kannan K, et al. Oncogene, 2001 Jun 7. PMID 11423996
  5. Potential target genes of EMX2 include Odz/Ten-M and other gene families with implications for cortical patterning. Li H, et al. Mol Cell Neurosci, 2006 Oct. PMID 16919471

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Hippocalcin-Like 1 blunts liver lipid metabolism to suppress tumorigenesis via directly targeting RUVBL1-mTOR signaling.
    Title: Hippocalcin-Like 1 blunts liver lipid metabolism to suppress tumorigenesis via directly targeting RUVBL1-mTOR signaling.
  2. visinin-like protein-3 interacts with microsomal cytochrome b5 in a Ca2+-dependent manner
    Title: Neuronal calcium sensor protein visinin-like protein-3 interacts with microsomal cytochrome b5 in a Ca2+-dependent manner.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (1) 
  • Endonuclease-mediated (1)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
hippocalcin-like protein 1
Names
neural visinin-like protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001361645.1 → NP_001348574.1  hippocalcin-like protein 1

    Status: VALIDATED

    Source sequence(s)
    AC138342, AC154636
    Consensus CDS
    CCDS25830.1
    UniProtKB/Swiss-Prot
    P35333, P62748
    UniProtKB/TrEMBL
    E9PV73
    Conserved Domains (1) summary
    COG5126
    Location:13 → 179
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

  2. NM_001422995.1 → NP_001409924.1  hippocalcin-like protein 1

    Status: VALIDATED

    Source sequence(s)
    AC138342, AC154636
    UniProtKB/Swiss-Prot
    P35333, P62748

  3. NM_001422996.1 → NP_001409925.1  hippocalcin-like protein 1

    Status: VALIDATED

    Source sequence(s)
    AC138342, AC154636
    UniProtKB/Swiss-Prot
    P35333, P62748

  4. NM_001422997.1 → NP_001409926.1  hippocalcin-like protein 1

    Status: VALIDATED

    Source sequence(s)
    AC138342, AC154636
    UniProtKB/Swiss-Prot
    P35333, P62748

  5. NM_001422998.1 → NP_001409927.1  hippocalcin-like protein 1

    Status: VALIDATED

    Source sequence(s)
    AC138342, AC154636
    UniProtKB/Swiss-Prot
    P35333, P62748

  6. NM_016677.5 → NP_057886.1  hippocalcin-like protein 1

    See identical proteins and their annotated locations for NP_057886.1

    Status: VALIDATED

    Source sequence(s)
    AC138342, AC154636
    Consensus CDS
    CCDS25830.1
    UniProtKB/Swiss-Prot
    P35333, P62748
    UniProtKB/TrEMBL
    E9PV73
    Related
    ENSMUSP00000071756.4, ENSMUST00000071858.5
    Conserved Domains (1) summary
    COG5126
    Location:13 → 179
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    17740810..17841943
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030246812.2 → XP_030102672.1  hippocalcin-like protein 1 isoform X1

    UniProtKB/Swiss-Prot
    P35333, P62748
    UniProtKB/TrEMBL
    E9PV73
    Conserved Domains (1) summary
    COG5126
    Location:13 → 179
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

  2. XM_006515157.3 → XP_006515220.1  hippocalcin-like protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006515220.1

    UniProtKB/Swiss-Prot
    P35333, P62748
    UniProtKB/TrEMBL
    E9PV73
    Related
    ENSMUSP00000152772.2, ENSMUST00000222944.2
    Conserved Domains (1) summary
    COG5126
    Location:13 → 179
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

  3. XM_030246819.2 → XP_030102679.1  hippocalcin-like protein 1 isoform X1

    UniProtKB/Swiss-Prot
    P35333, P62748
    UniProtKB/TrEMBL
    E9PV73
    Conserved Domains (1) summary
    COG5126
    Location:13 → 179
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P62748.2 GenPept UniProtKB/Swiss-Prot:P62748

Gene LinkOut

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