Tsnax translin-associated factor X [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tsnaxprovided by MGI
Official Full Name: translin-associated factor Xprovided by MGI
Primary source: MGI:MGI:1855672
See related: Ensembl:ENSMUSG00000056820 AllianceGenome:MGI:1855672
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Trax
Summary: Predicted to enable A2A adenosine receptor binding activity; RNA binding activity; and endoribonuclease activity. Predicted to contribute to sequence-specific DNA binding activity and single-stranded DNA binding activity. Predicted to act upstream of or within cell differentiation and spermatogenesis. Located in cytoplasm. Is expressed in several structures, including body cavity or lining; genitourinary system; respiratory system; tail; and vertebral axis musculature. Orthologous to human TSNAX (translin associated factor X). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in cortex adult (RPKM 51.2), CNS E18 (RPKM 49.9) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 E2; 8 73.1 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (125739780..125760947)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (125013041..125034208)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Conformational alteration in glycan induces phospholipase Cbeta1 activation and angiogenesis.
Title: Conformational alteration in glycan induces phospholipase Cβ1 activation and angiogenesis.
Selective role of the translin/trax RNase complex in hippocampal synaptic plasticity.
Title: Selective role of the translin/trax RNase complex in hippocampal synaptic plasticity.
Genetic inactivation of the translin/trax microRNA-degrading enzyme phenocopies the robust adiposity induced by Translin (Tsn) deletion.
Title: Genetic inactivation of the translin/trax microRNA-degrading enzyme phenocopies the robust adiposity induced by Translin (Tsn) deletion.
Deletion of the TN/TX complex selectively increases aortic miR-181b and prevents increased vascular stiffness caused by ingestion of high-salt water.
Title: Deletion of the microRNA-degrading nuclease, translin/trax, prevents pathogenic vascular stiffness.
Thus, the authors define a new memory mechanism by which learning reverses microRNA-mediated silencing of the novel plasticity protein ACVR1C via translin/trax.
Title: Learning induces the translin/trax RNase complex to express activin receptors for persistent memory.
TRAX is required for DNA repair, by interacting with activated ATM and protects cells from genotoxic stress-induced apoptosis.
Title: A central role of TRAX in the ATM-mediated DNA repair.
trax acts to regulate translin's RNA and DNA binding affinities as part of a cellular RNA trafficking mechanism.
Title: Analysis of nucleic acid binding by a recombinant translin-trax complex.
The TB-RBP-related and -interacting protein Translin-associated factor X was reduced to 50% normal levels in heterozygotes and was absent in TB-RBP-null animals.
Title: Mice deficient for testis-brain RNA-binding protein exhibit a coordinate loss of TRAX, reduced fertility, altered gene expression in the brain, and behavioral changes.
subcellular locations of TB-RBP and TRAX in male germ cells are modulated by the relative ratios of TRAX and TB-RBP
Title: The relative levels of translin-associated factor X (TRAX) and testis brain RNA-binding protein determine their nucleocytoplasmic distribution in male germ cells.
Trax was found to accumulate in the Golgi complex of mid-late pachytene spermatocytes
Title: Co-localization of Trax and Mea2 in Golgi complex of pachytene spermatocytes in the mouse.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Endonuclease-mediated (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Tsnax (e-PCR), detects polymorphism
- UniSTS:164703

D10Mit157.2 (e-PCR), detects polymorphism
- UniSTS:126061

RH125115 (e-PCR)
- UniSTS:161937

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables A2A adenosine receptor binding	ISO Inferred from Sequence Orthology more info
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA endonuclease activity	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
contributes_to sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
contributes_to single-stranded DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within multicellular organism development	IEA Inferred from Electronic Annotation more info
involved_in regulatory ncRNA-mediated post-transcriptional gene silencing	NAS Non-traceable Author Statement more info	PubMed
involved_in siRNA processing	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within spermatogenesis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
part_of endoribonuclease complex	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: translin-associated protein X

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.