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Chst3 carbohydrate sulfotransferase 3 [ Mus musculus (house mouse) ]

Gene ID: 53374, updated on 21-Apr-2024

Summary

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Official Symbol
Chst3provided by MGI
Official Full Name
carbohydrate sulfotransferase 3provided by MGI
Primary source
MGI:MGI:1858224
See related
Ensembl:ENSMUSG00000057337 AllianceGenome:MGI:1858224
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
C6ST; GST-0; C6ST-1
Summary
Enables chondroitin 6-sulfotransferase activity and proteoglycan sulfotransferase activity. Acts upstream of or within T cell homeostasis and chondroitin sulfate biosynthetic process. Predicted to be located in Golgi membrane. Predicted to be integral component of membrane. Predicted to be active in trans-Golgi network. Is expressed in several structures, including brain; genitourinary system; gut; immune system; and respiratory system. Used to study schizophrenia. Human ortholog(s) of this gene implicated in osteochondrodysplasia and spondyloepiphyseal dysplasia with congenital joint dislocations. Orthologous to human CHST3 (carbohydrate sulfotransferase 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in spleen adult (RPKM 18.8), mammary gland adult (RPKM 4.5) and 5 other tissues See more
Orthologs
human all
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Genomic context

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Location:
10 B4; 10 29.7 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (60017349..60057936, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (60181527..60222114, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene sparc/osteonectin, cwcv and kazal-like domains proteoglycan 2 Neighboring gene microRNA 6906 Neighboring gene STARR-positive B cell enhancer ABC_E5138 Neighboring gene predicted gene, 51802 Neighboring gene STARR-seq mESC enhancer starr_26799 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:59631170-59631353 Neighboring gene STARR-positive B cell enhancer ABC_E10611 Neighboring gene STARR-positive B cell enhancer mm9_chr10:59652431-59652731 Neighboring gene STARR-positive B cell enhancer ABC_E11440 Neighboring gene STARR-positive B cell enhancer mm9_chr10:59692925-59693225 Neighboring gene headcase homolog pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E2325 Neighboring gene STARR-seq mESC enhancer starr_26804 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:59740166-59740349 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:59747447-59747650 Neighboring gene prosaposin

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. RNA interference targeting carbohydrate sulfotransferase 3 diminishes macrophage accumulation, inhibits MMP-9 expression and promotes lung recovery in murine pulmonary emphysema. Kai Y, et al. Respir Res, 2015 Dec 9. PMID 26646821, Free PMC Article
  2. Involvement of chondroitin 6-sulfation in temporal lobe epilepsy. Yutsudo N, et al. Exp Neurol, 2015 Dec. PMID 26231575
  3. 6-Sulphated chondroitins have a positive influence on axonal regeneration. Lin R, et al. PLoS One, 2011. PMID 21747937, Free PMC Article
  4. Persistent cortical plasticity by upregulation of chondroitin 6-sulfation. Miyata S, et al. Nat Neurosci, 2012 Jan 15. PMID 22246436
  5. Functional analysis of the chondroitin 6-sulfotransferase gene in relation to lymphocyte subpopulations, brain development, and oversulfated chondroitin sulfates. Uchimura K, et al. J Biol Chem, 2002 Jan 11. PMID 11696535

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CHST3 siRNA diminishes accumulation of excessive macrophages and the mediators, leading to accelerate the functional recovery from airway damage by repair of the elastin network associated with pulmonary emphysema
    Title: RNA interference targeting carbohydrate sulfotransferase 3 diminishes macrophage accumulation, inhibits MMP-9 expression and promotes lung recovery in murine pulmonary emphysema.
  2. These results suggested that chondroitin 6-sulfation is relevant to epilepsy most probably because of dysregulated perineuronal nets formation and parvalbumin cell maturation.
    Title: Involvement of chondroitin 6-sulfation in temporal lobe epilepsy.
  3. neither KSGal6ST nor C6ST-1 is required for Siglec-F ligand synthesis in leukocytes or lung tissue
    Title: Galactose 6-O-sulfotransferases are not required for the generation of Siglec-F ligands in leukocytes or lung tissue.
  4. the expression of chondroitin 6-sulfotransferase correlated negatively with mast cell maturation.
    Title: Mast cell differentiation and activation is closely linked to expression of genes coding for the serglycin proteoglycan core protein and a distinct set of chondroitin sulfate and heparin sulfotransferases.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables N-acetylglucosamine 6-O-sulfotransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables chondroitin 6-sulfotransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables chondroitin 6-sulfotransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables chondroitin 6-sulfotransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables keratan sulfotransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables proteoglycan sulfotransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables proteoglycan sulfotransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables sulfotransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in N-acetylglucosamine metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within T cell homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in chondroitin sulfate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within chondroitin sulfate biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in chondroitin sulfate biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within chondroitin sulfate biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in chondroitin sulfate biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in sulfur compound metabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in trans-Golgi network IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
carbohydrate sulfotransferase 3
Names
carbohydrate (chondroitin 6/keratan) sulfotransferase 3
chondroitin 6-O-sulfotransferase 1
chondroitin 6-sulfotransferase
galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 0
NP_001393954.1
NP_058083.3
XP_011241812.1
XP_011241815.1
XP_017169519.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001407025.1 → NP_001393954.1  carbohydrate sulfotransferase 3

    Status: VALIDATED

    Source sequence(s)
    AC155640
    UniProtKB/Swiss-Prot
    O88199, Q794I5
    Related
    ENSMUSP00000065010.7, ENSMUST00000068690.7

  2. NM_016803.4 → NP_058083.3  carbohydrate sulfotransferase 3

    Status: VALIDATED

    Source sequence(s)
    AC155640
    Consensus CDS
    CCDS23871.2
    UniProtKB/Swiss-Prot
    O88199, Q794I5
    Related
    ENSMUSP00000131532.2, ENSMUST00000167915.3

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    60017349..60057936 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017314030.2 → XP_017169519.1  carbohydrate sulfotransferase 3 isoform X1

    UniProtKB/TrEMBL
    G5E8X5
    Conserved Domains (1) summary
    pfam00685
    Location:265 → 451
    Sulfotransfer_1; Sulfotransferase domain

  2. XM_011243510.4 → XP_011241812.1  carbohydrate sulfotransferase 3 isoform X1

    See identical proteins and their annotated locations for XP_011241812.1

    UniProtKB/TrEMBL
    G5E8X5
    Conserved Domains (1) summary
    pfam00685
    Location:265 → 451
    Sulfotransfer_1; Sulfotransferase domain

  3. XM_011243513.4 → XP_011241815.1  carbohydrate sulfotransferase 3 isoform X1

    See identical proteins and their annotated locations for XP_011241815.1

    UniProtKB/TrEMBL
    G5E8X5
    Conserved Domains (1) summary
    pfam00685
    Location:265 → 451
    Sulfotransfer_1; Sulfotransferase domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O88199.1 GenPept UniProtKB/Swiss-Prot:O88199

Gene LinkOut

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