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Tomm40 translocase of outer mitochondrial membrane 40 [ Mus musculus (house mouse) ]

Gene ID: 53333, updated on 11-Apr-2024

Summary

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Official Symbol
Tomm40provided by MGI
Official Full Name
translocase of outer mitochondrial membrane 40provided by MGI
Primary source
MGI:MGI:1858259
See related
Ensembl:ENSMUSG00000002984 AllianceGenome:MGI:1858259
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mom35; Tom40
Summary
Predicted to enable cation channel activity; preprotein binding activity; and protein transmembrane transporter activity. Predicted to be involved in positive regulation of apoptotic process; protein import into mitochondrial matrix; and protein insertion into mitochondrial membrane. Predicted to act upstream of or within ion transport and protein transport. Located in mitochondrial outer membrane. Is integral component of mitochondrial membrane. Is expressed in lung mesenchyme. Human ortholog(s) of this gene implicated in cerebral infarction. Orthologous to human TOMM40 (translocase of outer mitochondrial membrane 40). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 63.6), ovary adult (RPKM 47.8) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
7 A3; 7 9.94 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (19435238..19449370, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (19701313..19715442, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene apolipoprotein C-I Neighboring gene apolipoprotein E Neighboring gene predicted gene, 38955 Neighboring gene nectin cell adhesion molecule 2 Neighboring gene STARR-seq mESC enhancer starr_18217 Neighboring gene STARR-seq mESC enhancer starr_18218 Neighboring gene predicted gene, 34744 Neighboring gene basal cell adhesion molecule Neighboring gene STARR-seq mESC enhancer starr_18221

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Cloning and characterization of a 35-kDa mouse mitochondrial outer membrane protein MOM35 with high homology to Tom40. Rivera IL, et al. J Bioenerg Biomembr, 2000 Feb. PMID 11768756
  2. Genetic identity and differential expression of p38.5 (Haymaker) in human malignant and nonmalignant cells. Das B, et al. Int J Cancer, 2001 Dec 15. PMID 11745481
  3. TOM40 mediates mitochondrial dysfunction induced by α-synuclein accumulation in Parkinson's disease. Bender A, et al. PLoS One, 2013. PMID 23626796, Free PMC Article
  4. Editing activity for eliminating mischarged tRNAs is essential in mammalian mitochondria. Hilander T, et al. Nucleic Acids Res, 2018 Jan 25. PMID 29228266, Free PMC Article
  5. Mitochondrial fission factor Drp1 is essential for embryonic development and synapse formation in mice. Ishihara N, et al. Nat Cell Biol, 2009 Aug. PMID 19578372

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TOM40 mediates the effect of TSPO on postpartum depression partially through regulating calcium homeostasis in microglia.
    Title: TOM40 mediates the effect of TSPO on postpartum depression partially through regulating calcium homeostasis in microglia.
  2. the interaction of alpha-Syn with the mitochondrial protein import machinery, in particular Tom40, might be an upstream event in alpha-Syn-induced neurotoxicity.
    Title: TOM40 mediates mitochondrial dysfunction induced by α-synuclein accumulation in Parkinson's disease.
  3. imported into the outer mitochondrial membrane
    Title: Cloning and characterization of a 35-kDa mouse mitochondrial outer membrane protein MOM35 with high homology to Tom40.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC118268

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables monoatomic cation channel activity ISO
Inferred from Sequence Orthology
more info
  
enables porin activity IEA
Inferred from Electronic Annotation
more info
  
enables preprotein binding ISO
Inferred from Sequence Orthology
more info
  
enables protein transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in protein import into mitochondrial matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein insertion into mitochondrial membrane ISO
Inferred from Sequence Orthology
more info
  
involved_in protein targeting to mitochondrion ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondria-associated endoplasmic reticulum membrane contact site ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrial membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrial outer membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrial outer membrane ISO
Inferred from Sequence Orthology
more info
  
part_of mitochondrial outer membrane translocase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of mitochondrial outer membrane translocase complex ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion HDA PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
part_of pore complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
mitochondrial import receptor subunit TOM40 homolog
Names
haymaker protein
mitochondrial outer membrane protein 35
mitochondrial outer membrane protein of 35 kDa
translocase of outer membrane 40 kDa subunit homolog
translocase of outer mitochondrial membrane 40 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001109748.1 → NP_001103218.1  mitochondrial import receptor subunit TOM40 homolog

    See identical proteins and their annotated locations for NP_001103218.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK150019, AK165173, AW493492, BY231811
    Consensus CDS
    CCDS52062.1
    UniProtKB/Swiss-Prot
    Q3TBZ2, Q3TQA1, Q8VI26, Q8VI27, Q9QYA2, Q9Z2N1
    Related
    ENSMUSP00000032555.10, ENSMUST00000032555.10
    Conserved Domains (1) summary
    cd07305
    Location:77 → 361
    Porin3_Tom40; Translocase of outer mitochondrial membrane 40 (Tom40)

  2. NM_016871.2 → NP_058567.2  mitochondrial import receptor subunit TOM40 homolog

    See identical proteins and their annotated locations for NP_058567.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK165173, AW493492, BY231811
    Consensus CDS
    CCDS52062.1
    UniProtKB/Swiss-Prot
    Q3TBZ2, Q3TQA1, Q8VI26, Q8VI27, Q9QYA2, Q9Z2N1
    Related
    ENSMUSP00000104090.5, ENSMUST00000093552.12
    Conserved Domains (1) summary
    cd07305
    Location:77 → 361
    Porin3_Tom40; Translocase of outer mitochondrial membrane 40 (Tom40)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    19435238..19449370 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030242769.2 → XP_030098629.1  mitochondrial import receptor subunit TOM40 homolog isoform X1

    Conserved Domains (1) summary
    cd07305
    Location:1 → 208
    Porin3_Tom40; Translocase of outer mitochondrial membrane 40 (Tom40)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9QYA2.3 GenPept UniProtKB/Swiss-Prot:Q9QYA2

Gene LinkOut

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