Batf basic leucine zipper transcription factor, ATF-like [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Batfprovided by MGI
Official Full Name: basic leucine zipper transcription factor, ATF-likeprovided by MGI
Primary source: MGI:MGI:1859147
See related: Ensembl:ENSMUSG00000034266 AllianceGenome:MGI:1859147
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: B-ATF; SFA-2
Summary: Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including defense response to protozoan; immune system development; and positive regulation of macromolecule metabolic process. Located in cytoplasm and nucleus. Is expressed in bladder and testis. Orthologous to human BATF (basic leucine zipper ATF-like transcription factor). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in spleen adult (RPKM 6.8), thymus adult (RPKM 3.8) and 21 other tissues See more
Orthologs: human all
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Genomic context

Location:: 12 D2; 12 39.78 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	12	NC_000078.7 (85733494..85755861)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	12	NC_000078.6 (85686720..85709087)

Chromosome 12 - NC_000078.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

BATF is Required for Treg Homeostasis and Stability to Prevent Autoimmune Pathology.
Title: BATF is Required for Treg Homeostasis and Stability to Prevent Autoimmune Pathology.
Depletion of BATF in CAR-T cells enhances antitumor activity by inducing resistance against exhaustion and formation of central memory cells.
Title: Depletion of BATF in CAR-T cells enhances antitumor activity by inducing resistance against exhaustion and formation of central memory cells.
Group 3 innate lymphoid cells require BATF to regulate gut homeostasis in mice.
Title: Group 3 innate lymphoid cells require BATF to regulate gut homeostasis in mice.
Ablation of BATF Alleviates Transplant Rejection via Abrogating the Effector Differentiation and Memory Responses of CD8(+) T Cells.
Title: Ablation of BATF Alleviates Transplant Rejection via Abrogating the Effector Differentiation and Memory Responses of CD8(+) T Cells.
Genetically targeting the BATF family transcription factors BATF and BATF3 in the mouse abrogates effector T cell activities and enables long-term heart allograft survival.
Title: Genetically targeting the BATF family transcription factors BATF and BATF3 in the mouse abrogates effector T cell activities and enables long-term heart allograft survival.
Batf-mediated epigenetic control of effector CD8(+) T cell differentiation.
Title: Batf-mediated epigenetic control of effector CD8(+) T cell differentiation.
BATF promotes group 2 innate lymphoid cell-mediated lung tissue protection during acute respiratory virus infection.
Title: BATF promotes group 2 innate lymphoid cell-mediated lung tissue protection during acute respiratory virus infection.
BATF regulates innate lymphoid cell hematopoiesis and homeostasis.
Title: BATF regulates innate lymphoid cell hematopoiesis and homeostasis.
BATF and IRF4 cooperate to counter exhaustion in tumor-infiltrating CAR T cells.
Title: BATF and IRF4 cooperate to counter exhaustion in tumor-infiltrating CAR T cells.
BATF regulates progenitor to cytolytic effector CD8(+) T cell transition during chronic viral infection.
Title: BATF regulates progenitor to cytolytic effector CD8(+) T cell transition during chronic viral infection.

Submit: New GeneRIF Correction See all GeneRIFs (46)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (5) 1 citation
Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IMP Inferred from Mutant Phenotype more info	PubMed
enables DNA-binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in DNA damage response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in DNA damage response, signal transduction by p53 class mediator	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in T-helper 17 cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in T-helper 17 cell lineage commitment	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in T-helper 2 cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in defense response to protozoan	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in hematopoietic stem cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in isotype switching	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lymphoid progenitor cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in myeloid dendritic cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cytokine production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of RNA polymerase II transcription regulator complex	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: basic leucine zipper transcriptional factor ATF-like

Names: B-cell-activating transcription factor; activating transcription factor B; basic leucine zipper transcription factor-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_016767.2 → NP_058047.1 basic leucine zipper transcriptional factor ATF-like

See identical proteins and their annotated locations for NP_058047.1

Status: PROVISIONAL

Source sequence(s)

AC115037, AC117240

Consensus CDS

CCDS26061.1

UniProtKB/Swiss-Prot

A2RT86, O35284

Related

ENSMUSP00000040706.6, ENSMUST00000040536.6

Conserved Domains (1) summary

cd14701
Location:26 → 83

bZIP_BATF; Basic leucine zipper (bZIP) domain of BATF proteins: a DNA-binding and dimerization domain