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Nub1 negative regulator of ubiquitin-like proteins 1 [ Mus musculus (house mouse) ]

Gene ID: 53312, updated on 5-Mar-2024

Summary

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Official Symbol
Nub1provided by MGI
Official Full Name
negative regulator of ubiquitin-like proteins 1provided by MGI
Primary source
MGI:MGI:1889001
See related
Ensembl:ENSMUSG00000028954 AllianceGenome:MGI:1889001
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
BS4; NY-REN-18; 4931404D21Rik; 6330412F12Rik
Summary
Predicted to be involved in positive regulation of proteasomal ubiquitin-dependent protein catabolic process; protein ubiquitination; and ubiquitin-dependent protein catabolic process. Predicted to be located in cytosol; nucleolus; and nucleoplasm. Is expressed in several structures, including alimentary system; brain; eye; genitourinary system; and hemolymphoid system gland. Orthologous to human NUB1 (negative regulator of ubiquitin like proteins 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta adult (RPKM 36.3), lung adult (RPKM 24.5) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
5 A3; 5 11.93 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (24890813..24915376)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (24685815..24710378)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene chondroitin polymerizing factor 2 Neighboring gene SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3 Neighboring gene glycerol-3-phosphate dehydrogenase 1-like pseudogene Neighboring gene STARR-seq mESC enhancer starr_12645 Neighboring gene STARR-positive B cell enhancer mm9_chr5:24180078-24180378 Neighboring gene STARR-positive B cell enhancer ABC_E1298 Neighboring gene STARR-positive B cell enhancer ABC_E11722 Neighboring gene WD repeat domain 86 Neighboring gene VISTA enhancer mm394 Neighboring gene predicted gene, 42231 Neighboring gene STARR-seq mESC enhancer starr_12647 Neighboring gene predicted gene, 33591 Neighboring gene crystallin, gamma N

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The role of NUB1 in α-synuclein degradation in Lewy body disease model mice. Tanji K, et al. Biochem Biophys Res Commun, 2016 Feb 12. PMID 26797281
  2. NEDD8 Ultimate Buster 1 Long (NUB1L) Protein Suppresses Atypical Neddylation and Promotes the Proteasomal Degradation of Misfolded Proteins. Li J, et al. J Biol Chem, 2015 Sep 25. PMID 26260793, Free PMC Article
  3. Regulation of the NEDD8 conjugation system by a splicing variant, NUB1L. Tanaka T, et al. J Biol Chem, 2003 Aug 29. PMID 12816948
  4. FAT10 and NUB1L cooperate to activate the 26S proteasome. Brockmann F, et al. Life Sci Alliance, 2023 Aug. PMID 37188463, Free PMC Article
  5. Targeting of NEDD8 and its conjugates for proteasomal degradation by NUB1. Kamitani T, et al. J Biol Chem, 2001 Dec 7. PMID 11585840

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. FAT10 and NUB1L cooperate to activate the 26S proteasome.
    Title: FAT10 and NUB1L cooperate to activate the 26S proteasome.
  2. These results suggest that increased levels of NUB1 play a potential role in degradation of detergent-insoluble alpha-synuclein in vivo, although it is insufficient to degrade abnormal alpha-synuclein in Lewy body disease model mice.
    Title: The role of NUB1 in α-synuclein degradation in Lewy body disease model mice.
  3. NUB1L suppresses atypical neddylation and promotes the degradation of misfolded proteins by the proteasome
    Title: NEDD8 Ultimate Buster 1 Long (NUB1L) Protein Suppresses Atypical Neddylation and Promotes the Proteasomal Degradation of Misfolded Proteins.
  4. NUB1 has a splicing variant, NUB1L, which regulates the NEDD8 conjugation system
    Title: Regulation of the NEDD8 conjugation system by a splicing variant, NUB1L.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within proteasomal protein catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Lewy body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
NEDD8 ultimate buster 1
Names
NY-REN-18 antigen

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001305264.1 → NP_001292193.1  NEDD8 ultimate buster 1 isoform 1

    See identical proteins and their annotated locations for NP_001292193.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC137938, AI853857, AK086301, AK153400
    Consensus CDS
    CCDS80230.1
    UniProtKB/TrEMBL
    A0A0G2JGQ4
    Related
    ENSMUSP00000143657.2, ENSMUST00000197407.5
    Conserved Domains (3) summary
    cd14291
    Location:399 → 434
    UBA1_NUB1_like; UBA1 domain found in NEDD8 ultimate buster 1 (NUB1) and similar proteins
    cd14293
    Location:516 → 551
    UBA3_NUB1; UBA3 domain found in NEDD8 ultimate buster 1 (NUB1) and similar proteins
    cl21463
    Location:457 → 491
    UBA_like_SF; UBA domain-like superfamily

  2. NM_016736.3 → NP_058016.2  NEDD8 ultimate buster 1 isoform 2

    See identical proteins and their annotated locations for NP_058016.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and uses an alternate splice site in the 5' coding region, which results in use of a downstream start codon compared to variant 1. The encoded isoform (2) has a shorter N-terminus than isoform 1.
    Source sequence(s)
    AC137938, AI853857, AK086301, AK134581
    Consensus CDS
    CCDS39030.1
    UniProtKB/Swiss-Prot
    P54729, Q8K3U0
    UniProtKB/TrEMBL
    Q3UYM1
    Related
    ENSMUSP00000070265.7, ENSMUST00000068825.8
    Conserved Domains (3) summary
    cd14291
    Location:375 → 410
    UBA1_NUB1_like; UBA1 domain found in NEDD8 ultimate buster 1 (NUB1) and similar proteins
    cd14293
    Location:492 → 527
    UBA3_NUB1; UBA3 domain found in NEDD8 ultimate buster 1 (NUB1) and similar proteins
    cl21463
    Location:433 → 467
    UBA_like_SF; UBA domain-like superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    24890813..24915376
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P54729.2 GenPept UniProtKB/Swiss-Prot:P54729

Gene LinkOut

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