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Cdipt CDP-diacylglycerol--inositol 3-phosphatidyltransferase [ Mus musculus (house mouse) ]

Gene ID: 52858, updated on 5-Mar-2024

Summary

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Official Symbol
Cdiptprovided by MGI
Official Full Name
CDP-diacylglycerol--inositol 3-phosphatidyltransferaseprovided by MGI
Primary source
MGI:MGI:105491
See related
Ensembl:ENSMUSG00000030682 AllianceGenome:MGI:105491
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pis; Pis1; D7Bwg0575e; 9530042F15Rik
Summary
Predicted to enable several functions, including CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity; diacylglycerol binding activity; and manganese ion binding activity. Predicted to be involved in CDP-diacylglycerol metabolic process and phosphatidylinositol biosynthetic process. Predicted to act upstream of or within phospholipid biosynthetic process. Predicted to be integral component of membrane. Predicted to be active in Golgi apparatus. Is expressed in musculature; nervous system; and urinary system. Orthologous to human CDIPT (CDP-diacylglycerol--inositol 3-phosphatidyltransferase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in large intestine adult (RPKM 67.2), duodenum adult (RPKM 64.3) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
7 F3; 7 69.26 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (126575630..126579671)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (126976458..126980499)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene seizure related 6 homolog like 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:134119536-134119823 Neighboring gene CDIP transferase, opposite strand Neighboring gene major vault protein Neighboring gene STARR-seq mESC enhancer starr_20161 Neighboring gene STARR-positive B cell enhancer ABC_E2850 Neighboring gene PAXIP1 associated glutamate rich protein 1A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Characterization of the null murine sodium/myo-inositol cotransporter 1 (Smit1 or Slc5a3) phenotype: myo-inositol rescue is independent of expression of its cognate mitochondrial ribosomal protein subunit 6 (Mrps6) gene and of phosphatidylinositol levels in neonatal brain. Buccafusca R, et al. Mol Genet Metab, 2008 Sep-Oct. PMID 18675571
  2. Interactome Analysis Reveals Regulator of G Protein Signaling 14 (RGS14) is a Novel Calcium/Calmodulin (Ca(2+)/CaM) and CaM Kinase II (CaMKII) Binding Partner. Evans PR, et al. J Proteome Res, 2018 Apr 6. PMID 29518331, Free PMC Article
  3. RNA binding proteins co-localize with small tau inclusions in tauopathy. Maziuk BF, et al. Acta Neuropathol Commun, 2018 Aug 1. PMID 30068389, Free PMC Article
  4. Genetic mapping of 262 loci derived from expressed sequences in a murine interspecific cross using single-strand conformational polymorphism analysis. Brady KP, et al. Genome Res, 1997 Nov. PMID 9371744, Free PMC Article
  5. Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors. Kim H, et al. Cell, 2018 Dec 13. PMID 30550785, Free PMC Article

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (2) 
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables alcohol binding ISO
Inferred from Sequence Orthology
more info
  
enables carbohydrate binding ISO
Inferred from Sequence Orthology
more info
  
enables diacylglycerol binding ISO
Inferred from Sequence Orthology
more info
  
enables manganese ion binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphotransferase activity, for other substituted phosphate groups IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in CDP-diacylglycerol metabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in phosphatidylinositol biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phosphatidylinositol biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within phospholipid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in phospholipid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
CDP-diacylglycerol--inositol 3-phosphatidyltransferase
Names
PI synthase
phosphatidylinositol synthase
ptdIns synthase
NP_001334585.1
NP_001366189.1
NP_080914.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001347656.2 → NP_001334585.1  CDP-diacylglycerol--inositol 3-phosphatidyltransferase isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice junction compared to variant 1, that causes a frameshift. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC122863
    Consensus CDS
    CCDS85418.1
    UniProtKB/TrEMBL
    A0A0U1RNI6, A0A0U1RPV3
    Related
    ENSMUSP00000146137.2, ENSMUST00000206346.2

  2. NM_001379260.1 → NP_001366189.1  CDP-diacylglycerol--inositol 3-phosphatidyltransferase isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) represents the longest transcript and encodes the longest isoform (3).
    Source sequence(s)
    AC122863
    UniProtKB/TrEMBL
    A0A0U1RP13
    Conserved Domains (1) summary
    pfam01066
    Location:10 → 72
    CDP-OH_P_transf; CDP-alcohol phosphatidyltransferase

  3. NM_026638.4 → NP_080914.1  CDP-diacylglycerol--inositol 3-phosphatidyltransferase isoform 1

    See identical proteins and their annotated locations for NP_080914.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AC122863
    Consensus CDS
    CCDS21853.1
    UniProtKB/Swiss-Prot
    Q8VDP6
    UniProtKB/TrEMBL
    A0A0U1RP13
    Related
    ENSMUSP00000032920.4, ENSMUST00000032920.5
    Conserved Domains (1) summary
    pfam01066
    Location:10 → 72
    CDP-OH_P_transf; CDP-alcohol phosphatidyltransferase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    126575630..126579671
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8VDP6.1 GenPept UniProtKB/Swiss-Prot:Q8VDP6

Gene LinkOut

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