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Mtg2 mitochondrial ribosome associated GTPase 2 [ Mus musculus (house mouse) ]

Gene ID: 52856, updated on 5-Mar-2024

Summary

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Official Symbol
Mtg2provided by MGI
Official Full Name
mitochondrial ribosome associated GTPase 2provided by MGI
Primary source
MGI:MGI:106565
See related
Ensembl:ENSMUSG00000039069 AllianceGenome:MGI:106565
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gtpbp5; D2Bwg0647e; 1810011P19Rik; 2900056P18Rik
Summary
Predicted to enable GTP binding activity and GTPase activity. Predicted to be involved in regulation of mitochondrial translation and regulation of respiratory system process. Located in mitochondrion. Orthologous to human MTG2 (mitochondrial ribosome associated GTPase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 5.5), CNS E14 (RPKM 5.4) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
2 H4; 2 102.59 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (179712366..179727695)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (180070573..180085902)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene proteasome subunit alpha 7 Neighboring gene STARR-positive B cell enhancer ABC_E7897 Neighboring gene SS18, nBAF chromatin remodeling complex subunit like 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:179830439-179830640 Neighboring gene histamine receptor H3 Neighboring gene predicted gene, 46782

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Diversification of stem cell molecular repertoire by alternative splicing. Pritsker M, et al. Proc Natl Acad Sci U S A, 2005 Oct 4. PMID 16183747, Free PMC Article
  2. Genetic mapping of 262 loci derived from expressed sequences in a murine interspecific cross using single-strand conformational polymorphism analysis. Brady KP, et al. Genome Res, 1997 Nov. PMID 9371744, Free PMC Article
  3. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
  4. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
  5. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in regulation of mitochondrial translation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of respiratory system process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrial matrix ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrial ribosome ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
mitochondrial ribosome-associated GTPase 2
Names
GTP binding protein 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001083328.1 → NP_001076797.1  mitochondrial ribosome-associated GTPase 2

    See identical proteins and their annotated locations for NP_001076797.1

    Status: VALIDATED

    Source sequence(s)
    BC028465, BF012021, BY726952, DT929445
    Consensus CDS
    CCDS38374.1
    UniProtKB/TrEMBL
    A2AFK4
    Conserved Domains (1) summary
    TIGR02729
    Location:112 → 387
    Obg_CgtA; Obg family GTPase CgtA

  2. NM_001083329.1 → NP_001076798.1  mitochondrial ribosome-associated GTPase 2

    See identical proteins and their annotated locations for NP_001076798.1

    Status: VALIDATED

    Source sequence(s)
    AW647214, BC028465, BY726952, DT929445
    Consensus CDS
    CCDS38374.1
    UniProtKB/TrEMBL
    A2AFK4
    Related
    ENSMUSP00000104529.2, ENSMUST00000108901.8
    Conserved Domains (1) summary
    TIGR02729
    Location:112 → 387
    Obg_CgtA; Obg family GTPase CgtA

  3. NM_028422.1 → NP_082698.1  mitochondrial ribosome-associated GTPase 2

    See identical proteins and their annotated locations for NP_082698.1

    Status: VALIDATED

    Source sequence(s)
    BC028465, BY726952, CX210755, DT929445
    Consensus CDS
    CCDS38374.1
    UniProtKB/TrEMBL
    A2AFK4
    Conserved Domains (1) summary
    TIGR02729
    Location:112 → 387
    Obg_CgtA; Obg family GTPase CgtA

  4. NM_181424.3 → NP_852089.2  mitochondrial ribosome-associated GTPase 2

    See identical proteins and their annotated locations for NP_852089.2

    Status: VALIDATED

    Source sequence(s)
    BC028465, BY726952, DT929445
    Consensus CDS
    CCDS38374.1
    UniProtKB/TrEMBL
    A2AFK4
    Conserved Domains (1) summary
    TIGR02729
    Location:112 → 387
    Obg_CgtA; Obg family GTPase CgtA

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    179712366..179727695
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036162385.1 → XP_036018278.1  mitochondrial ribosome-associated GTPase 2 isoform X8

    Conserved Domains (1) summary
    TIGR02729
    Location:112 → 271
    Obg_CgtA; Obg family GTPase CgtA

  2. XM_036162375.1 → XP_036018268.1  mitochondrial ribosome-associated GTPase 2 isoform X2

    Conserved Domains (1) summary
    TIGR02729
    Location:142 → 417
    Obg_CgtA; Obg family GTPase CgtA

  3. XM_036162378.1 → XP_036018271.1  mitochondrial ribosome-associated GTPase 2 isoform X4

    UniProtKB/TrEMBL
    A2AFK4
    Conserved Domains (1) summary
    TIGR02729
    Location:112 → 387
    Obg_CgtA; Obg family GTPase CgtA

  4. XM_030251869.2 → XP_030107729.1  mitochondrial ribosome-associated GTPase 2 isoform X4

    UniProtKB/TrEMBL
    A2AFK4
    Conserved Domains (1) summary
    TIGR02729
    Location:112 → 387
    Obg_CgtA; Obg family GTPase CgtA

  5. XM_036162380.1 → XP_036018273.1  mitochondrial ribosome-associated GTPase 2 isoform X4

    UniProtKB/TrEMBL
    A2AFK4
    Conserved Domains (1) summary
    TIGR02729
    Location:112 → 387
    Obg_CgtA; Obg family GTPase CgtA

  6. XM_036162389.1 → XP_036018282.1  mitochondrial ribosome-associated GTPase 2 isoform X11

    Conserved Domains (1) summary
    cl38936
    Location:117 → 229
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  7. XM_006500675.2 → XP_006500738.1  mitochondrial ribosome-associated GTPase 2 isoform X4

    See identical proteins and their annotated locations for XP_006500738.1

    UniProtKB/TrEMBL
    A2AFK4
    Conserved Domains (1) summary
    TIGR02729
    Location:112 → 387
    Obg_CgtA; Obg family GTPase CgtA

  8. XM_030251872.2 → XP_030107732.1  mitochondrial ribosome-associated GTPase 2 isoform X8

    Conserved Domains (1) summary
    TIGR02729
    Location:112 → 271
    Obg_CgtA; Obg family GTPase CgtA

  9. XM_030251865.2 → XP_030107725.1  mitochondrial ribosome-associated GTPase 2 isoform X2

    Conserved Domains (1) summary
    TIGR02729
    Location:142 → 417
    Obg_CgtA; Obg family GTPase CgtA

  10. XM_017319125.2 → XP_017174614.1  mitochondrial ribosome-associated GTPase 2 isoform X4

    UniProtKB/TrEMBL
    A2AFK4
    Conserved Domains (1) summary
    TIGR02729
    Location:112 → 387
    Obg_CgtA; Obg family GTPase CgtA

  11. XM_030251871.2 → XP_030107731.1  mitochondrial ribosome-associated GTPase 2 isoform X7

    Conserved Domains (1) summary
    TIGR02729
    Location:52 → 327
    Obg_CgtA; Obg family GTPase CgtA

  12. XM_011239951.2 → XP_011238253.1  mitochondrial ribosome-associated GTPase 2 isoform X4

    See identical proteins and their annotated locations for XP_011238253.1

    UniProtKB/TrEMBL
    A2AFK4
    Conserved Domains (1) summary
    TIGR02729
    Location:112 → 387
    Obg_CgtA; Obg family GTPase CgtA

  13. XM_030251873.2 → XP_030107733.1  mitochondrial ribosome-associated GTPase 2 isoform X8

    Conserved Domains (1) summary
    TIGR02729
    Location:112 → 271
    Obg_CgtA; Obg family GTPase CgtA

  14. XM_006500676.2 → XP_006500739.1  mitochondrial ribosome-associated GTPase 2 isoform X4

    See identical proteins and their annotated locations for XP_006500739.1

    UniProtKB/TrEMBL
    A2AFK4
    Conserved Domains (1) summary
    TIGR02729
    Location:112 → 387
    Obg_CgtA; Obg family GTPase CgtA

  15. XM_030251875.2 → XP_030107735.1  mitochondrial ribosome-associated GTPase 2 isoform X10

    UniProtKB/TrEMBL
    I6L986
    Conserved Domains (1) summary
    pfam01018
    Location:107 → 222
    GTP1_OBG; GTP1/OBG

  16. XM_036162377.1 → XP_036018270.1  mitochondrial ribosome-associated GTPase 2 isoform X4

    UniProtKB/TrEMBL
    A2AFK4
    Conserved Domains (1) summary
    TIGR02729
    Location:112 → 387
    Obg_CgtA; Obg family GTPase CgtA

  17. XM_036162376.1 → XP_036018269.1  mitochondrial ribosome-associated GTPase 2 isoform X2

    Conserved Domains (1) summary
    TIGR02729
    Location:142 → 417
    Obg_CgtA; Obg family GTPase CgtA

  18. XM_036162383.1 → XP_036018276.1  mitochondrial ribosome-associated GTPase 2 isoform X8

    Conserved Domains (1) summary
    TIGR02729
    Location:112 → 271
    Obg_CgtA; Obg family GTPase CgtA

  19. XM_036162387.1 → XP_036018280.1  mitochondrial ribosome-associated GTPase 2 isoform X10

    UniProtKB/TrEMBL
    I6L986
    Related
    ENSMUSP00000139273.2, ENSMUST00000184862.8
    Conserved Domains (1) summary
    pfam01018
    Location:107 → 222
    GTP1_OBG; GTP1/OBG

  20. XM_036162388.1 → XP_036018281.1  mitochondrial ribosome-associated GTPase 2 isoform X11

    Conserved Domains (1) summary
    cl38936
    Location:117 → 229
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  21. XM_006500672.2 → XP_006500735.1  mitochondrial ribosome-associated GTPase 2 isoform X2

    See identical proteins and their annotated locations for XP_006500735.1

    Conserved Domains (1) summary
    TIGR02729
    Location:142 → 417
    Obg_CgtA; Obg family GTPase CgtA

  22. XM_036162384.1 → XP_036018277.1  mitochondrial ribosome-associated GTPase 2 isoform X8

    Conserved Domains (1) summary
    TIGR02729
    Location:112 → 271
    Obg_CgtA; Obg family GTPase CgtA

  23. XM_036162382.1 → XP_036018275.1  mitochondrial ribosome-associated GTPase 2 isoform X7

    Conserved Domains (1) summary
    TIGR02729
    Location:52 → 327
    Obg_CgtA; Obg family GTPase CgtA

  24. XM_036162379.1 → XP_036018272.1  mitochondrial ribosome-associated GTPase 2 isoform X4

    UniProtKB/TrEMBL
    A2AFK4
    Conserved Domains (1) summary
    TIGR02729
    Location:112 → 387
    Obg_CgtA; Obg family GTPase CgtA

  25. XM_036162390.1 → XP_036018283.1  mitochondrial ribosome-associated GTPase 2 isoform X11

    Conserved Domains (1) summary
    cl38936
    Location:117 → 229
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  26. XM_030251868.2 → XP_030107728.1  mitochondrial ribosome-associated GTPase 2 isoform X4

    UniProtKB/TrEMBL
    A2AFK4
    Conserved Domains (1) summary
    TIGR02729
    Location:112 → 387
    Obg_CgtA; Obg family GTPase CgtA

  27. XM_017319124.1 → XP_017174613.1  mitochondrial ribosome-associated GTPase 2 isoform X1

    Conserved Domains (1) summary
    TIGR02729
    Location:222 → 497
    Obg_CgtA; Obg family GTPase CgtA

  28. XM_006500674.2 → XP_006500737.1  mitochondrial ribosome-associated GTPase 2 isoform X3

    Conserved Domains (1) summary
    TIGR02729
    Location:222 → 381
    Obg_CgtA; Obg family GTPase CgtA

  29. XM_006500677.3 → XP_006500740.1  mitochondrial ribosome-associated GTPase 2 isoform X5

    Conserved Domains (1) summary
    pfam01018
    Location:217 → 332
    GTP1_OBG; GTP1/OBG

  30. XM_036162386.1 → XP_036018279.1  mitochondrial ribosome-associated GTPase 2 isoform X9

    Conserved Domains (1) summary
    pfam01018
    Location:217 → 264
    GTP1_OBG; GTP1/OBG

  31. XM_036162381.1 → XP_036018274.1  mitochondrial ribosome-associated GTPase 2 isoform X6

    Conserved Domains (1) summary
    cl38936
    Location:227 → 339
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RNA

  1. XR_003953669.1 RNA Sequence

  2. XR_004940655.1 RNA Sequence

  3. XR_001783146.2 RNA Sequence

  4. XR_003953667.2 RNA Sequence

  5. XR_003953670.2 RNA Sequence

  6. XR_003953668.2 RNA Sequence

  7. XR_004940653.1 RNA Sequence

  8. XR_004940654.1 RNA Sequence

  9. XR_375400.3 RNA Sequence

  10. XR_003953666.1 RNA Sequence

Nucleotide Protein Strain
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