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Dbndd2 dysbindin domain containing 2 [ Mus musculus (house mouse) ]

Gene ID: 52840, updated on 5-Mar-2024

Summary

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Official Symbol
Dbndd2provided by MGI
Official Full Name
dysbindin domain containing 2provided by MGI
Primary source
MGI:MGI:106562
See related
Ensembl:ENSMUSG00000017734 AllianceGenome:MGI:106562
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Nkip; R74724; D2Bwg0891e; 1110017A21Rik; 2900022J10Rik
Summary
Predicted to be involved in negative regulation of protein kinase activity. Predicted to be located in cytoplasm. Is expressed in epithelium of phallic urethra of female; genital tubercle mesenchyme of female; genital tubercle mesenchyme of male; genital tubercle skin of male; and urethral plate. Orthologous to human DBNDD2 (dysbindin domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in cerebellum adult (RPKM 38.8), cortex adult (RPKM 22.6) and 22 other tissues See more
Orthologs
human all
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Genomic context

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Location:
2 H3; 2 85.17 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (164309073..164335243)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (164467153..164493323)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene matrilin 4 Neighboring gene STARR-positive B cell enhancer ABC_E6015 Neighboring gene recombination signal binding protein for immunoglobulin kappa J region-like Neighboring gene STARR-positive B cell enhancer ABC_E4517 Neighboring gene STARR-positive B cell enhancer ABC_E6016 Neighboring gene STARR-seq mESC enhancer starr_06326 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:164266728-164266915 Neighboring gene syndecan 4 Neighboring gene STARR-seq mESC enhancer starr_06330 Neighboring gene STARR-positive B cell enhancer ABC_E7884 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:164286295-164286478 Neighboring gene SYS1 Golgi-localized integral membrane protein homolog (S. cerevisiae) Neighboring gene transformation related protein 53 target 5 Neighboring gene STARR-positive B cell enhancer ABC_E9539 Neighboring gene phosphatidylinositol glycan anchor biosynthesis, class T Neighboring gene STARR-seq mESC enhancer starr_06331 Neighboring gene predicted gene, 36090

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Characterization of NKIP: a novel, Na+/K+-ATPase interacting protein mediates neural differentiation and apoptosis. Pratscher B, et al. Exp Cell Res, 2008 Feb 1. PMID 18096156
  2. The schizophrenia susceptibility gene dysbindin regulates dendritic spine dynamics. Jia JM, et al. J Neurosci, 2014 Oct 8. PMID 25297099, Free PMC Article
  3. Molecular Characterization of the Genital Organizer: Gene Expression Profile of the Mouse Urethral Plate Epithelium. Armfield BA, et al. J Urol, 2016 Oct. PMID 27173853, Free PMC Article
  4. Somatic cell hybrids for high-density mapping of chromosome 2 breakpoints in radiation-induced myeloid leukemia cell lines from inbred mice. Pazzaglia S, et al. Mol Carcinog, 2000 Mar. PMID 10708484
  5. PITX2c is expressed in the adult left atrium, and reducing Pitx2c expression promotes atrial fibrillation inducibility and complex changes in gene expression. Kirchhof P, et al. Circ Cardiovasc Genet, 2011 Apr. PMID 21282332

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3) 
  • Endonuclease-mediated (2) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in negative regulation of protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of protein kinase activity ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
dysbindin domain-containing protein 2
Names
SCF apoptosis response protein 1
dysbindin (dystrobrevin binding protein 1) domain containing 2
likely orthologue of H. sapiens chromosome 20 open reading frame 35

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001048227.1 → NP_001041692.1  dysbindin domain-containing protein 2

    See identical proteins and their annotated locations for NP_001041692.1

    Status: VALIDATED

    Source sequence(s)
    AL591478, BG080686, CX241653
    Consensus CDS
    CCDS38322.1
    UniProtKB/Swiss-Prot
    Q9CRD4
    UniProtKB/TrEMBL
    Q330P7
    Related
    ENSMUSP00000104974.3, ENSMUST00000109350.9
    Conserved Domains (1) summary
    pfam04440
    Location:12 → 80
    Dysbindin; Dysbindin (Dystrobrevin binding protein 1)

  2. NM_001048228.1 → NP_001041693.1  dysbindin domain-containing protein 2

    See identical proteins and their annotated locations for NP_001041693.1

    Status: VALIDATED

    Source sequence(s)
    AK003735, AL591478
    Consensus CDS
    CCDS38322.1
    UniProtKB/Swiss-Prot
    Q9CRD4
    UniProtKB/TrEMBL
    Q330P7
    Related
    ENSMUSP00000104973.3, ENSMUST00000109349.9
    Conserved Domains (1) summary
    pfam04440
    Location:12 → 80
    Dysbindin; Dysbindin (Dystrobrevin binding protein 1)

  3. NM_001048229.1 → NP_001041694.1  dysbindin domain-containing protein 2

    See identical proteins and their annotated locations for NP_001041694.1

    Status: VALIDATED

    Source sequence(s)
    AL591478, CJ156083, CX241653
    Consensus CDS
    CCDS38322.1
    UniProtKB/Swiss-Prot
    Q9CRD4
    UniProtKB/TrEMBL
    Q330P7
    Related
    ENSMUSP00000017878.3, ENSMUST00000017878.3
    Conserved Domains (1) summary
    pfam04440
    Location:12 → 80
    Dysbindin; Dysbindin (Dystrobrevin binding protein 1)

  4. NM_026797.2 → NP_081073.1  dysbindin domain-containing protein 2

    See identical proteins and their annotated locations for NP_081073.1

    Status: VALIDATED

    Source sequence(s)
    AL591478, CX241653
    Consensus CDS
    CCDS38322.1
    UniProtKB/Swiss-Prot
    Q9CRD4
    UniProtKB/TrEMBL
    Q330P7
    Related
    ENSMUSP00000064437.9, ENSMUST00000069385.15
    Conserved Domains (1) summary
    pfam04440
    Location:12 → 80
    Dysbindin; Dysbindin (Dystrobrevin binding protein 1)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    164309073..164335243
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006499895.3 → XP_006499958.1  dysbindin domain-containing protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006499958.1

    UniProtKB/Swiss-Prot
    Q9CRD4
    UniProtKB/TrEMBL
    Q330P7
    Conserved Domains (1) summary
    pfam04440
    Location:12 → 80
    Dysbindin; Dysbindin (Dystrobrevin binding protein 1)

  2. XM_030251864.2 → XP_030107724.1  dysbindin domain-containing protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q9CRD4
    UniProtKB/TrEMBL
    Q330P7
    Conserved Domains (1) summary
    pfam04440
    Location:12 → 80
    Dysbindin; Dysbindin (Dystrobrevin binding protein 1)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CRD4.1 GenPept UniProtKB/Swiss-Prot:Q9CRD4

Gene LinkOut

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