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Krr1 KRR1, small subunit (SSU) processome component, homolog (yeast) [ Mus musculus (house mouse) ]

Gene ID: 52705, updated on 5-Mar-2024

Summary

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Official Symbol
Krr1provided by MGI
Official Full Name
KRR1, small subunit (SSU) processome component, homolog (yeast)provided by MGI
Primary source
MGI:MGI:1289274
See related
Ensembl:ENSMUSG00000063334 AllianceGenome:MGI:1289274
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Hrb2; D10Ertd773e; 2610511F02Rik
Summary
Predicted to enable RNA binding activity. Predicted to act upstream of or within rRNA processing. Predicted to be located in chromosome; intercellular bridge; and nucleoplasm. Predicted to be part of small-subunit processome. Predicted to be active in nucleolus. Is expressed in axial skeleton; brain; esophagus; head mesenchyme; and lung. Orthologous to human KRR1 (KRR1 small subunit processome component homolog). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 9.9), bladder adult (RPKM 6.8) and 24 other tissues See more
Orthologs
human all
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Genomic context

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Location:
10 D1- D2; 10 59.97 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (111808600..111824335)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (111972695..111988430)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene S-adenosylmethionine decarboxylase, pseudogene 3 pseudogene Neighboring gene STARR-seq mESC enhancer starr_27889 Neighboring gene STARR-seq mESC enhancer starr_27890 Neighboring gene STARR-seq mESC enhancer starr_27891 Neighboring gene predicted gene, 20758 Neighboring gene STARR-seq mESC enhancer starr_27892 Neighboring gene STARR-seq mESC enhancer starr_27894 Neighboring gene STARR-positive B cell enhancer mm9_chr10:111362554-111362854 Neighboring gene STARR-positive B cell enhancer ABC_E5182 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:111409583-111409851 Neighboring gene STARR-seq mESC enhancer starr_27895 Neighboring gene STARR-positive B cell enhancer ABC_E2340 Neighboring gene STARR-positive B cell enhancer ABC_E1813 Neighboring gene STARR-positive B cell enhancer ABC_E3914 Neighboring gene GLI pathogenesis related 1 Neighboring gene calcyphosphine 2 pseudogene Neighboring gene GLI pathogenesis-related 1 like 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A genome-wide in situ hybridization map of RNA-binding proteins reveals anatomically restricted expression in the developing mouse brain. McKee AE, et al. BMC Dev Biol, 2005 Jul 20. PMID 16033648, Free PMC Article
  2. Matrix-screening reveals a vast potential for direct protein-protein interactions among RNA binding proteins. Lang B, et al. Nucleic Acids Res, 2021 Jul 9. PMID 34133714, Free PMC Article
  3. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article
  4. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article
  5. Fancd2 in vivo interaction network reveals a non-canonical role in mitochondrial function. Zhang T, et al. Sci Rep, 2017 Apr 5. PMID 28378742, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within rRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in ribosomal small subunit biogenesis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within ribosome biogenesis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in chromosome ISO
Inferred from Sequence Orthology
more info
  
located_in intercellular bridge ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
  
part_of small-subunit processome IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of small-subunit processome ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
KRR1 small subunit processome component homolog
Names
HIV-1 Rev binding protein 2
HIV-1 Rev-binding protein 2 homolog
KRR-R motif-containing protein 1
KRR1, small subunit processome component

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_178610.4 → NP_848725.2  KRR1 small subunit processome component homolog

    See identical proteins and their annotated locations for NP_848725.2

    Status: VALIDATED

    Source sequence(s)
    AC167231, AK041854, CD547185
    Consensus CDS
    CCDS24168.1
    UniProtKB/Swiss-Prot
    Q3UIG9, Q52KQ6, Q5EBJ5, Q8BGA5, Q8C029
    UniProtKB/TrEMBL
    G3UZA0
    Related
    ENSMUSP00000125746.2, ENSMUST00000163048.8
    Conserved Domains (2) summary
    smart00322
    Location:157 → 207
    KH; K homology RNA-binding domain
    COG1094
    Location:55 → 240
    Krr1; rRNA processing protein Krr1/Pno1, contains KH domain [Translation, ribosomal structure and biogenesis]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    111808600..111824335
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BGA5.1 GenPept UniProtKB/Swiss-Prot:Q8BGA5

Gene LinkOut

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