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Nudcd2 NudC domain containing 2 [ Mus musculus (house mouse) ]

Gene ID: 52653, updated on 11-Apr-2024

Summary

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Official Symbol
Nudcd2provided by MGI
Official Full Name
NudC domain containing 2provided by MGI
Primary source
MGI:MGI:1277103
See related
Ensembl:ENSMUSG00000020328 AllianceGenome:MGI:1277103
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable unfolded protein binding activity. Predicted to be involved in protein folding. Predicted to be located in cytosol; intercellular bridge; and mitotic spindle. Predicted to be active in cytoplasm. Is expressed in embryo. Orthologous to human NUDCD2 (NudC domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E11.5 (RPKM 31.9), liver E14 (RPKM 19.0) and 26 other tissues See more
Orthologs
human all
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Genomic context

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Location:
11 A5; 11 24.41 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (40624485..40630873)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (40733645..40740046)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E6966 Neighboring gene methionine adenosyltransferase 2 non-catalytic beta subunit methionine Neighboring gene STARR-seq mESC enhancer starr_29231 Neighboring gene STARR-seq mESC enhancer starr_29232 Neighboring gene hyaluronan mediated motility receptor (RHAMM) Neighboring gene STARR-seq mESC enhancer starr_29234 Neighboring gene cyclin G1 Neighboring gene STARR-seq mESC enhancer starr_29235 Neighboring gene predicted gene, 24446

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation. Barnes CE, et al. Mol Omics, 2022 Jan 17. PMID 34709266, Free PMC Article
  2. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article
  3. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article
  4. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249
  5. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • D11Ertd603e, 2700047N05Rik

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables unfolded protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in protein folding IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
located_in chromosome, centromeric region IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in intercellular bridge ISO
Inferred from Sequence Orthology
more info
  
located_in kinetochore IEA
Inferred from Electronic Annotation
more info
  
located_in microtubule cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
located_in mitotic spindle ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
nudC domain-containing protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001290697.2 → NP_001277626.1  nudC domain-containing protein 2 isoform 2

    See identical proteins and their annotated locations for NP_001277626.1

    Status: VALIDATED

    Source sequence(s)
    AL646055
    Consensus CDS
    CCDS70162.1
    UniProtKB/TrEMBL
    E0CYQ2
    Related
    ENSMUSP00000123991.2, ENSMUST00000127382.2
    Conserved Domains (1) summary
    cl00175
    Location:12 → 80
    alpha-crystallin-Hsps_p23-like; alpha-crystallin domain (ACD) found in alpha-crystallin-type small heat shock proteins, and a similar domain found in p23 (a cochaperone for Hsp90) and in other p23-like proteins.

  2. NM_001425561.1 → NP_001412490.1  nudC domain-containing protein 2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL646055

  3. NM_026023.6 → NP_080299.4  nudC domain-containing protein 2 isoform 1

    See identical proteins and their annotated locations for NP_080299.4

    Status: VALIDATED

    Source sequence(s)
    AL646055
    Consensus CDS
    CCDS24549.1
    UniProtKB/Swiss-Prot
    Q8CD03, Q9CQ48, Q9CY63, Q9D0V4
    Related
    ENSMUSP00000020578.5, ENSMUST00000020578.11
    Conserved Domains (1) summary
    cd06494
    Location:12 → 104
    p23_NUDCD2_like; p23-like NUD (nuclear distribution) C-like found in human NUDC domain-containing protein 2 (NUDCD2) and similar proteins. Little is known about the function of the proteins in this subgroup.

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    40624485..40630873
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CQ48.1 GenPept UniProtKB/Swiss-Prot:Q9CQ48

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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