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Nit2 nitrilase family, member 2 [ Mus musculus (house mouse) ]

Gene ID: 52633, updated on 5-Mar-2024

Summary

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Official Symbol
Nit2provided by MGI
Official Full Name
nitrilase family, member 2provided by MGI
Primary source
MGI:MGI:1261838
See related
Ensembl:ENSMUSG00000022751 AllianceGenome:MGI:1261838
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
D16Ertd502e; 1190017B19Rik
Summary
Predicted to enable omega-amidase activity. Predicted to be involved in asparagine metabolic process; glutamine metabolic process; and oxaloacetate metabolic process. Located in mitochondrion. Orthologous to human NIT2 (nitrilase family member 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in liver adult (RPKM 44.0), kidney adult (RPKM 21.9) and 25 other tissues See more
Orthologs
human all
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Genomic context

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Location:
16 C1.1; 16 34.22 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (56977028..56987695, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (57156665..57167332, complement)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene transmembrane protein 45A2 Neighboring gene STARR-positive B cell enhancer ABC_E1927 Neighboring gene translocase of outer mitochondrial membrane 70A Neighboring gene STARR-seq mESC enhancer starr_41078 Neighboring gene STARR-positive B cell enhancer ABC_E8637 Neighboring gene predicted gene, 16892 Neighboring gene TBC1 domain family, member 23 Neighboring gene STARR-positive B cell enhancer ABC_E11617 Neighboring gene STARR-positive B cell enhancer mm9_chr16:57231379-57231680 Neighboring gene STARR-seq mESC enhancer starr_41080 Neighboring gene STARR-seq mESC enhancer starr_41081 Neighboring gene STARR-seq mESC enhancer starr_41082 Neighboring gene transmembrane protein 30C Neighboring gene STARR-seq mESC enhancer starr_41083 Neighboring gene predicted gene, 26800

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Molecular identification of omega-amidase, the enzyme that is functionally coupled with glutamine transaminases, as the putative tumor suppressor Nit2. Jaisson S, et al. Biochimie, 2009 Sep. PMID 19596042
  2. Functional proteomic and structural insights into molecular recognition in the nitrilase family enzymes. Barglow KT, et al. Biochemistry, 2008 Dec 23. PMID 19053248, Free PMC Article
  3. Crystal structure of the worm NitFhit Rosetta Stone protein reveals a Nit tetramer binding two Fhit dimers. Pace HC, et al. Curr Biol, 2000 Jul 27-Aug 10. PMID 10959838
  4. Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Mootha VK, et al. Cell, 2003 Nov 26. PMID 14651853
  5. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data conclude that mammalian nitrilase 2 is omega-amidase.
    Title: Molecular identification of omega-amidase, the enzyme that is functionally coupled with glutamine transaminases, as the putative tumor suppressor Nit2.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (4) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides IEA
Inferred from Electronic Annotation
more info
  
enables omega-amidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables omega-amidase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in asparagine metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in asparagine metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in glutamine metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glutamine metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in nitrogen compound metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in oxaloacetate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in oxaloacetate metabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion HDA PubMed 

General protein information

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Preferred Names
omega-amidase NIT2
Names
Nit protein 2
nitrilase homolog 2
NP_075664.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_023175.1 → NP_075664.1  omega-amidase NIT2

    See identical proteins and their annotated locations for NP_075664.1

    Status: PROVISIONAL

    Source sequence(s)
    AF284573
    Consensus CDS
    CCDS37363.1
    UniProtKB/Swiss-Prot
    Q9CTG9, Q9JHW2
    Related
    ENSMUSP00000023432.9, ENSMUST00000023432.10
    Conserved Domains (1) summary
    cd07572
    Location:5 → 265
    nit; Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    56977028..56987695 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9JHW2.1 GenPept UniProtKB/Swiss-Prot:Q9JHW2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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