Adgre4 adhesion G protein-coupled receptor E4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Adgre4provided by MGI
Official Full Name: adhesion G protein-coupled receptor E4provided by MGI
Primary source: MGI:MGI:1196464
See related: Ensembl:ENSMUSG00000032915 AllianceGenome:MGI:1196464
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Emr4; Fire; Gpr127; Egf-tm7; D17Ertd479e
Summary: Predicted to enable G protein-coupled receptor activity. Predicted to be involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway. Predicted to act upstream of or within epidermal growth factor receptor signaling pathway. Located in cell surface. Is expressed in alimentary system; gonad; and metanephros. Orthologous to several human genes including ADGRE3 (adhesion G protein-coupled receptor E3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in spleen adult (RPKM 6.8), lung adult (RPKM 1.5) and 8 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17 D; 17 28.98 cM

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (56056984..56160662)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (55749984..55853662)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Two alternatively spliced human FIRE transcripts were identified, neither are predicted to express the TM7 cassette. Thus, if the human FIRE exists, it is likely to be expressed as a soluble secreted molecule.
Title: Gene structure and transcript analysis of the human and mouse EGF-TM7 molecule, FIRE.
activated in mucosal [and cutaneous]wounds
Title: Different mechanisms of syndecan-1 activation through a fibroblast-growth-factor-inducible response element (FiRE) in mucosal and cutaneous wounds.
the first EGF-TM7 receptor known to mediate the cellular interaction between myeloid cells and B cells
Title: EMR4, a novel epidermal growth factor (EGF)-TM7 molecule up-regulated in activated mouse macrophages, binds to a putative cellular ligand on B lymphoma cell line A20.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables transmembrane signaling receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell surface receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within epidermal growth factor receptor signaling pathway	ISA Inferred from Sequence Alignment more info	PubMed
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISA Inferred from Sequence Alignment more info	PubMed

General protein information

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Preferred Names: adhesion G protein-coupled receptor E4

Names: EGF-like module containing, mucin-like, hormone receptor-like sequence 4; EGF-like module receptor 4; EGF-like module-containing mucin-like hormone receptor-like 4; F4/80-like-receptor; seven-span membrane protein FIRE

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_139138.3 → NP_631877.2 adhesion G protein-coupled receptor E4 precursor

See identical proteins and their annotated locations for NP_631877.2

Status: VALIDATED

Source sequence(s)

AF396935, AK036459, AK037483, CT573084

Consensus CDS

CCDS50148.1

UniProtKB/Swiss-Prot

Q3U1I7, Q8BYX0, Q8VIM3, Q91ZE5

UniProtKB/TrEMBL

Q0VBQ8

Related

ENSMUSP00000025004.7, ENSMUST00000025004.7

Conserved Domains (4) summary

smart00179
Location:77 → 105

EGF_CA; Calcium-binding EGF-like domain

pfam01825
Location:290 → 332

GPS; GPCR proteolysis site, GPS, motif

pfam16489
Location:214 → 262

GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

cl21561
Location:343 → 588

7tm_4; Olfactory receptor