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Cbx7 chromobox 7 [ Mus musculus (house mouse) ]

Gene ID: 52609, updated on 21-Apr-2024

Summary

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Official Symbol
Cbx7provided by MGI
Official Full Name
chromobox 7provided by MGI
Primary source
MGI:MGI:1196439
See related
Ensembl:ENSMUSG00000053411 AllianceGenome:MGI:1196439
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
D15Ertd417e; 1600014J01Rik
Summary
Enables chromatin binding activity; methylated histone binding activity; and single-stranded RNA binding activity. Acts upstream of or within sebaceous gland development. Located in heterochromatin and nucleus. Part of PRC1 complex. Is expressed in brain. Human ortholog(s) of this gene implicated in breast cancer; multiple myeloma; and myeloid leukemia. Orthologous to human CBX7 (chromobox 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in spleen adult (RPKM 23.7), placenta adult (RPKM 17.2) and 24 other tissues See more
Orthologs
human all
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Genomic context

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Location:
15 E1; 15 37.85 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (79800005..79855344, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (79915804..79971143, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene predicted gene 10856 Neighboring gene STARR-seq mESC enhancer starr_39199 Neighboring gene RIKEN cDNA D730005E14 gene Neighboring gene STARR-positive B cell enhancer ABC_E7391 Neighboring gene STARR-positive B cell enhancer ABC_E4141 Neighboring gene STARR-positive B cell enhancer ABC_E3147 Neighboring gene apolipoprotein B mRNA editing enzyme, catalytic polypeptide 3 Neighboring gene STARR-seq mESC enhancer starr_39200 Neighboring gene STARR-seq mESC enhancer starr_39204 Neighboring gene STARR-positive B cell enhancer ABC_E7392 Neighboring gene STARR-positive B cell enhancer mm9_chr15:79765174-79765475 Neighboring gene STARR-positive B cell enhancer ABC_E9420 Neighboring gene VISTA enhancer mm570 Neighboring gene STARR-seq mESC enhancer starr_39213 Neighboring gene predicted gene, 53903 Neighboring gene microRNA 7213 Neighboring gene platelet derived growth factor, B polypeptide

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. CBX7 Rejuvenates Late Passage Dental Pulp Stem Cells by Maintaining Stemness and Pro-angiogenic Ability. Wu Y, et al. Tissue Eng Regen Med, 2023 Jun. PMID 36920677, Free PMC Article
  2. Neuroprotection of chromobox 7 knockout in the mouse after cerebral ischemia-reperfusion injury via nuclear factor E2-related factor 2/hemeoxygenase-1 signaling pathway. Zhang HT, et al. Hum Exp Toxicol, 2022 Jan-Dec. PMID 35435747
  3. A Polycomb domain found in committed cells impairs differentiation when introduced into PRC1 in pluripotent cells. Jaensch ES, et al. Mol Cell, 2021 Nov 18. PMID 34637753, Free PMC Article
  4. Mammalian CBX7 isoforms p36 and p22 exhibit differential responses to serum, varying functions for proliferation, and distinct subcellular localization. Cho KW, et al. Sci Rep, 2020 May 15. PMID 32415167, Free PMC Article
  5. Effect of CBX7 deficiency on the socket healing after tooth extractions. Jiang F, et al. J Bone Miner Metab, 2019 Jul. PMID 30238429

See all (59) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Polycomb Group Protein CBX7 Represses Cardiomyocyte Proliferation Through Modulation of the TARDBP/RBM38 Axis.
    Title: Polycomb Group Protein CBX7 Represses Cardiomyocyte Proliferation Through Modulation of the TARDBP/RBM38 Axis.
  2. CBX7 Rejuvenates Late Passage Dental Pulp Stem Cells by Maintaining Stemness and Pro-angiogenic Ability.
    Title: CBX7 Rejuvenates Late Passage Dental Pulp Stem Cells by Maintaining Stemness and Pro-angiogenic Ability.
  3. Neuroprotection of chromobox 7 knockout in the mouse after cerebral ischemia-reperfusion injury via nuclear factor E2-related factor 2/hemeoxygenase-1 signaling pathway.
    Title: Neuroprotection of chromobox 7 knockout in the mouse after cerebral ischemia-reperfusion injury via nuclear factor E2-related factor 2/hemeoxygenase-1 signaling pathway.
  4. A Polycomb domain found in committed cells impairs differentiation when introduced into PRC1 in pluripotent cells.
    Title: A Polycomb domain found in committed cells impairs differentiation when introduced into PRC1 in pluripotent cells.
  5. Mass spectrometry analysis revealed several non-histone protein interactions between CBX7 and the H3K9 methyltransferases SETDB1, EHMT1, and EHMT2. These CBX7-binding proteins possess a trimethylated lysine peptide motif highly similar to the canonical CBX7 target H3K27me3.
    Title: CBX7 Induces Self-Renewal of Human Normal and Malignant Hematopoietic Stem and Progenitor Cells by Canonical and Non-canonical Interactions.
  6. Knockdown of CBX7 in either embryonic cortical neurons or adult dorsal root ganglion (DRG) neurons enhances their axon growth ability. Two important transcription factors GATA4 and SOX11 are functional downstream targets of CBX7 in controlling axon regeneration.
    Title: Polycomb protein family member CBX7 regulates intrinsic axon growth and regeneration.
  7. CBX7 deficiency has a positive effect on tooth extraction socket healing.
    Title: Effect of CBX7 deficiency on the socket healing after tooth extractions.
  8. Here, by combining live-cell single-molecule tracking (SMT) and genetic engineering, the authors reveal that H3K27me3 contributes significantly to the targeting of Cbx7-PRC1 complex to chromatin.
    Title: Live-cell single-molecule tracking reveals co-recognition of H3K27me3 and DNA targets polycomb Cbx7-PRC1 to chromatin.
  9. these results of this study suggest that CBX7 deficiency plays a positive role in dentin and alveolar bone formation.
    Title: CBX7 deficiency plays a positive role in dentin and alveolar bone development.
  10. CD4(+) T cells express Cbx7; the latter prevents FasL expression and the activation-induced CD4(+) T cell apoptosis.
    Title: Polycomb chromobox (Cbx) 7 modulates activation-induced CD4+ T cell apoptosis.
Submit: New GeneRIF Correction See all GeneRIFs (16)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (5)  1 citation
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables chromatin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables methylated histone binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables single-stranded RNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within chromatin organization IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription elongation by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within sebaceous gland development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of PRC1 complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of PcG protein complex ISO
Inferred from Sequence Orthology
more info
  
part_of chromatin ISO
Inferred from Sequence Orthology
more info
  
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
part_of heterochromatin IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
chromobox protein homolog 7
Names
chromobox homolog 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_144811.3 → NP_659060.1  chromobox protein homolog 7

    See identical proteins and their annotated locations for NP_659060.1

    Status: VALIDATED

    Source sequence(s)
    AC113595, BC042657, BQ571764
    Consensus CDS
    CCDS37143.1
    UniProtKB/Swiss-Prot
    Q8VDS3
    Related
    ENSMUSP00000105245.3, ENSMUST00000109616.9
    Conserved Domains (1) summary
    pfam00385
    Location:13 → 60
    Chromo; Chromo (CHRromatin Organization MOdifier) domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    79800005..79855344 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011245690.3 → XP_011243992.1  chromobox protein homolog 7 isoform X2

    UniProtKB/TrEMBL
    A0A6M8AZW7
    Conserved Domains (2) summary
    pfam17218
    Location:188 → 219
    CBX7_C; CBX family C-terminal motif
    cl28914
    Location:15 → 41
    CD_CSD; CHROMO (CHRromatin Organization Modifier) domains and chromo shadow domains

  2. XM_011245691.3 → XP_011243993.1  chromobox protein homolog 7 isoform X3

    See identical proteins and their annotated locations for XP_011243993.1

    Conserved Domains (1) summary
    pfam17218
    Location:155 → 186
    CBX7_C; CBX family C-terminal motif

  3. XM_006521148.4 → XP_006521211.1  chromobox protein homolog 7 isoform X5

    Conserved Domains (1) summary
    pfam17218
    Location:96 → 127
    CBX7_C; CBX family C-terminal motif

  4. XM_006521147.5 → XP_006521210.1  chromobox protein homolog 7 isoform X4

    Conserved Domains (2) summary
    cd18646
    Location:7 → 62
    CD_Cbx7; chromodomain of chromobox homolog 7
    pfam17218
    Location:150 → 181
    CBX7_C; CBX family C-terminal motif

  5. XM_006521144.5 → XP_006521207.1  chromobox protein homolog 7 isoform X1

    UniProtKB/TrEMBL
    A0A6M8AZW7, F8WHN2
    Related
    ENSMUSP00000086708.5, ENSMUST00000089293.11
    Conserved Domains (2) summary
    cd18646
    Location:7 → 62
    CD_Cbx7; chromodomain of chromobox homolog 7
    pfam17218
    Location:209 → 240
    CBX7_C; CBX family C-terminal motif

  6. XM_011245692.4 → XP_011243994.1  chromobox protein homolog 7 isoform X3

    See identical proteins and their annotated locations for XP_011243994.1

    Conserved Domains (1) summary
    pfam17218
    Location:155 → 186
    CBX7_C; CBX family C-terminal motif

RNA

  1. XR_003951404.2 RNA Sequence

  2. XR_384025.5 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8VDS3.1 GenPept UniProtKB/Swiss-Prot:Q8VDS3

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