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Brms1l breast cancer metastasis-suppressor 1-like [ Mus musculus (house mouse) ]

Gene ID: 52592, updated on 5-Mar-2024

Summary

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Official Symbol
Brms1lprovided by MGI
Official Full Name
breast cancer metastasis-suppressor 1-likeprovided by MGI
Primary source
MGI:MGI:1196337
See related
Ensembl:ENSMUSG00000012076 AllianceGenome:MGI:1196337
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
BRMS1; D12Ertd407e; 0710008O11Rik
Summary
Predicted to enable histone deacetylase binding activity. Predicted to be involved in histone deacetylation and negative regulation of transcription by RNA polymerase II. Predicted to act upstream of or within regulation of growth. Predicted to be located in nucleus. Predicted to be part of Sin3-type complex. Orthologous to human BRMS1L (BRMS1 like transcriptional repressor). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E18 (RPKM 23.2), frontal lobe adult (RPKM 20.6) and 24 other tissues See more
Orthologs
human all
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Genomic context

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Location:
12 C1; 12 24.18 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (55883109..55916521)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (55836324..55869736)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene Ral GTPase activating protein, alpha subunit 1 Neighboring gene insulinoma-associated 2 Neighboring gene STARR-seq mESC enhancer starr_32196 Neighboring gene STARR-seq mESC enhancer starr_32197 Neighboring gene STARR-positive B cell enhancer ABC_E11776 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:56937027-56937210 Neighboring gene STARR-seq mESC enhancer starr_32198 Neighboring gene predicted gene, 22296 Neighboring gene predicted gene, 53722

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. β-catenin regulates GnRH-induced FSHβ gene expression. Wang Q, et al. Mol Endocrinol, 2013 Feb. PMID 23211523, Free PMC Article
  2. Fam60a defines a variant Sin3a-Hdac complex in embryonic stem cells required for self-renewal. Streubel G, et al. EMBO J, 2017 Aug 1. PMID 28554894, Free PMC Article
  3. Human family with sequence similarity 60 member A (FAM60A) protein: a new subunit of the Sin3 deacetylase complex. Smith KT, et al. Mol Cell Proteomics, 2012 Dec. PMID 22984288, Free PMC Article
  4. SAP30, a novel protein conserved between human and yeast, is a component of a histone deacetylase complex. Zhang Y, et al. Mol Cell, 1998 Jun. PMID 9651585
  5. Family with sequence similarity 60A (FAM60A) protein is a cell cycle-fluctuating regulator of the SIN3-HDAC1 histone deacetylase complex. Muñoz IM, et al. J Biol Chem, 2012 Sep 21. PMID 22865885, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables histone deacetylase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in negative regulation of cell migration NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in negative regulation of stem cell population maintenance NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of transcription by RNA polymerase II NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in negative regulation of transforming growth factor beta receptor signaling pathway NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in positive regulation of stem cell population maintenance NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
part_of Sin3-type complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
breast cancer metastasis-suppressor 1-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001037756.3 → NP_001032845.1  breast cancer metastasis-suppressor 1-like protein

    See identical proteins and their annotated locations for NP_001032845.1

    Status: VALIDATED

    Source sequence(s)
    AK155742, BC034885
    Consensus CDS
    CCDS36453.1
    UniProtKB/Swiss-Prot
    Q3U1T3, Q8JZX8
    Related
    ENSMUSP00000082500.5, ENSMUST00000059250.8
    Conserved Domains (1) summary
    pfam08598
    Location:61 → 179
    Sds3; Sds3-like

RNA

  1. NR_155205.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC159624, CR974464

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    55883109..55916521
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_381530.4 RNA Sequence

  2. XR_004937525.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_027867.2: Suppressed sequence

    Description
    NM_027867.2: This RefSeq was permanently suppressed because it is a nonsense-mediated decay (NMD) candidate.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3U1T3.1 GenPept UniProtKB/Swiss-Prot:Q3U1T3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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