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Tspan14 tetraspanin 14 [ Mus musculus (house mouse) ]

Gene ID: 52588, updated on 21-Apr-2024

Summary

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Official Symbol
Tspan14provided by MGI
Official Full Name
tetraspanin 14provided by MGI
Primary source
MGI:MGI:1196325
See related
Ensembl:ENSMUSG00000037824 AllianceGenome:MGI:1196325
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tm4sf14; tspan-14; D14Ertd226e
Summary
Enables enzyme binding activity. Involved in protein maturation. Located in cell surface and tetraspanin-enriched microdomain. Is expressed in several structures, including central nervous system; retina; and salivary gland. Orthologous to human TSPAN14 (tetraspanin 14). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta adult (RPKM 50.8), kidney adult (RPKM 41.8) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
14 B; 14 22.36 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (40628384..40688835, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (40906427..40967073, complement)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene STARR-seq mESC enhancer starr_36460 Neighboring gene STARR-seq mESC enhancer starr_36461 Neighboring gene STARR-seq mESC enhancer starr_36462 Neighboring gene SH2 domain containing 4B Neighboring gene STARR-seq mESC enhancer starr_36464 Neighboring gene STARR-seq mESC enhancer starr_36467 Neighboring gene STARR-seq mESC enhancer starr_36469 Neighboring gene STARR-positive B cell enhancer ABC_E9893 Neighboring gene VISTA enhancer mm1503 Neighboring gene STARR-positive B cell enhancer ABC_E4105 Neighboring gene STARR-positive B cell enhancer ABC_E8554 Neighboring gene STARR-positive B cell enhancer ABC_E5429 Neighboring gene predicted gene, 31839 Neighboring gene peroxiredoxin like 2A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The TspanC8 subgroup of tetraspanins interacts with A disintegrin and metalloprotease 10 (ADAM10) and regulates its maturation and cell surface expression. Haining EJ, et al. J Biol Chem, 2012 Nov 16. PMID 23035126, Free PMC Article
  2. Appearance of new tetraspanin genes during vertebrate evolution. Garcia-España A, et al. Genomics, 2008 Apr. PMID 18291621
  3. A novel view of the transcriptome revealed from gene trapping in mouse embryonic stem cells. Roma G, et al. Genome Res, 2007 Jul. PMID 17540781, Free PMC Article
  4. Gene expression in the developing mouse retina by EST sequencing and microarray analysis. Mu X, et al. Nucleic Acids Res, 2001 Dec 15. PMID 11812828, Free PMC Article
  5. ADAM10 hyperactivation acts on piccolo to deplete synaptic vesicle stores in Huntington's disease. Cozzolino F, et al. Hum Mol Genet, 2021 Jun 17. PMID 33601422

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC36554

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables enzyme binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in positive regulation of Notch signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in protein localization to plasma membrane ISO
Inferred from Sequence Orthology
more info
  
involved_in protein maturation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein maturation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cell surface IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in tetraspanin-enriched microdomain IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
tetraspanin-14
Names
transmembrane 4 superfamily member 14

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001316748.1 → NP_001303677.1  tetraspanin-14

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC108430, AK030593, BG807867
    Consensus CDS
    CCDS26956.1
    UniProtKB/Swiss-Prot
    Q8QZY6
    Related
    ENSMUSP00000153208.2, ENSMUST00000224209.2
    Conserved Domains (1) summary
    cd03159
    Location:113 → 233
    TM4SF9_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF9_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...

  2. NM_145928.3 → NP_666040.1  tetraspanin-14

    See identical proteins and their annotated locations for NP_666040.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC154597, CT025537
    Consensus CDS
    CCDS26956.1
    UniProtKB/Swiss-Prot
    Q8QZY6
    Related
    ENSMUSP00000035263.6, ENSMUST00000047652.6
    Conserved Domains (1) summary
    cd03159
    Location:113 → 233
    TM4SF9_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF9_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...

RNA

  1. NR_188877.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC108430, AC154597, CT025537

  2. NR_188878.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    BY232291, CT025537

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    40628384..40688835 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036158755.1 → XP_036014648.1  tetraspanin-14 isoform X1

    UniProtKB/Swiss-Prot
    Q8QZY6
    Conserved Domains (1) summary
    cd03159
    Location:113 → 233
    TM4SF9_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF9_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...

  2. XM_006519261.2 → XP_006519324.1  tetraspanin-14 isoform X1

    See identical proteins and their annotated locations for XP_006519324.1

    UniProtKB/Swiss-Prot
    Q8QZY6
    Conserved Domains (1) summary
    cd03159
    Location:113 → 233
    TM4SF9_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF9_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...

  3. XM_036158753.1 → XP_036014646.1  tetraspanin-14 isoform X1

    UniProtKB/Swiss-Prot
    Q8QZY6
    Conserved Domains (1) summary
    cd03159
    Location:113 → 233
    TM4SF9_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF9_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8QZY6.1 GenPept UniProtKB/Swiss-Prot:Q8QZY6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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