Trmt10c tRNA methyltransferase 10C, mitochondrial RNase P subunit [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Trmt10cprovided by MGI
Official Full Name: tRNA methyltransferase 10C, mitochondrial RNase P subunitprovided by MGI
Primary source: MGI:MGI:1196261
See related: Ensembl:ENSMUSG00000044763 AllianceGenome:MGI:1196261
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Rnmtd1; Rg9mtd1; D16Ertd454e; 1300018J16Rik
Summary: Predicted to enable RNA methyltransferase activity; identical protein binding activity; and tRNA binding activity. Predicted to be involved in RNA metabolic process and positive regulation of mitochondrial translation. Predicted to act upstream of or within methylation. Located in mitochondrion. Is expressed in several structures, including central nervous system; metanephros; phalanx; skin; and tooth. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 30. Orthologous to human TRMT10C (tRNA methyltransferase 10C, mitochondrial RNase P subunit). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 9.1), liver E14 (RPKM 8.2) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 16 C1.1; 16 33.79 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	16	NC_000082.7 (55854083..55858149, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	16	NC_000082.6 (56033720..56037786, complement)

Chromosome 16 - NC_000082.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D16Ertd454e (e-PCR), detects polymorphism
- UniSTS:167188

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables tRNA (adenine(9)-N1)-methyltransferase activity	ISO Inferred from Sequence Orthology more info
enables tRNA (guanosine(9)-N1)-methyltransferase activity	ISO Inferred from Sequence Orthology more info
enables tRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables tRNA binding	ISO Inferred from Sequence Orthology more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within methylation	IEA Inferred from Electronic Annotation more info
involved_in mitochondrial RNA 5'-end processing	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial tRNA 3'-end processing	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial tRNA 5'-end processing	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrial tRNA 5'-end processing	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial tRNA methylation	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial tRNA processing	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mitochondrial translation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of mitochondrial translation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within tRNA processing	IEA Inferred from Electronic Annotation more info
involved_in tRNA processing	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in mitochondrial nucleoid	ISO Inferred from Sequence Orthology more info
part_of mitochondrial ribonuclease P complex	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
is_active_in nucleoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
part_of tRNA methyltransferase complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: tRNA methyltransferase 10 homolog C

Names: RNA (guanine-9-) methyltransferase domain containing 1; RNA (guanine-9-)-methyltransferase domain-containing protein 1; mRNA methyladenosine-N(1)-methyltransferase; mitochondrial RNase P protein 1; mitochondrial ribonuclease P protein 1; tRNA (adenine(9)-N(1))-methyltransferase; tRNA (guanine(9)-N(1))-methyltransferase

NP_083368.1

EC 2.1.1.218

EC 2.1.1.221

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.