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Cenpo centromere protein O [ Mus musculus (house mouse) ]

Gene ID: 52504, updated on 5-Mar-2024

Summary

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Official Symbol
Cenpoprovided by MGI
Official Full Name
centromere protein Oprovided by MGI
Primary source
MGI:MGI:1923800
See related
Ensembl:ENSMUSG00000020652 AllianceGenome:MGI:1923800
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
D12Ertd482e; 2810429O05Rik; 8430427C03Rik
Summary
Predicted to be involved in centromere complex assembly. Predicted to be located in nuclear body. Predicted to be part of Mis6-Sim4 complex. Is expressed in several structures, including central nervous system; genitourinary system; jaw; sensory organ; and thymus primordium. Orthologous to human CENPO (centromere protein O). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 4.3), thymus adult (RPKM 4.2) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
12 A1.1; 12 2.02 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (4243548..4284255, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (4195398..4234255, complement)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr12:4082834-4083134 Neighboring gene DnaJ heat shock protein family (Hsp40) member C27 Neighboring gene STARR-seq mESC enhancer starr_31436 Neighboring gene predicted gene, 53749 Neighboring gene adenylate cyclase 3 Neighboring gene ubiquitin associated protein 2-like pseudogene Neighboring gene predicted gene, 29696 Neighboring gene peptidyl-tRNA hydrolase domain containing 1 Neighboring gene nuclear receptor coactivator 1 Neighboring gene STARR-seq mESC enhancer starr_31441 Neighboring gene aurora kinase A pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Systematic screening for skin, hair, and nail abnormalities in a large-scale knockout mouse program. Sundberg JP, et al. PLoS One, 2017. PMID 28700664, Free PMC Article
  2. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article
  3. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
  4. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
  5. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC36863

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in centromere complex assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in chromosome segregation NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
part_of Mis6-Sim4 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
located_in chromosome, centromeric region IEA
Inferred from Electronic Annotation
more info
  
part_of inner kinetochore ISO
Inferred from Sequence Orthology
more info
  
located_in kinetochore IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
centromere protein O

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001361641.1 → NP_001348570.1  centromere protein O isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC162932, CT572999
    Consensus CDS
    CCDS88302.1
    UniProtKB/TrEMBL
    B8JK52
    Related
    ENSMUSP00000020981.6, ENSMUST00000020981.12
    Conserved Domains (1) summary
    pfam09496
    Location:22 → 74
    CENP-O; Cenp-O kinetochore centromere component

  2. NM_134046.6 → NP_598807.2  centromere protein O isoform 1

    See identical proteins and their annotated locations for NP_598807.2

    Status: VALIDATED

    Source sequence(s)
    AC162932, CT572999
    Consensus CDS
    CCDS25788.1
    UniProtKB/Swiss-Prot
    Q8K015, Q8R587, Q9CYY6
    Related
    ENSMUSP00000119136.2, ENSMUST00000140975.8
    Conserved Domains (1) summary
    pfam09496
    Location:143 → 195
    CENP-O; Cenp-O kinetochore centromere component

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    4243548..4284255 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030246807.1 → XP_030102667.1  centromere protein O isoform X3

    UniProtKB/TrEMBL
    B8JK51
    Related
    ENSMUSP00000106799.4, ENSMUST00000111169.10
    Conserved Domains (2) summary
    COG3883
    Location:26 → 116
    CwlO1; Uncharacterized N-terminal domain of peptidoglycan hydrolase CwlO [Function unknown]
    pfam09496
    Location:124 → 195
    CENP-O; Cenp-O kinetochore centromere component

  2. XM_011243884.3 → XP_011242186.1  centromere protein O isoform X3

    See identical proteins and their annotated locations for XP_011242186.1

    UniProtKB/TrEMBL
    B8JK51
    Conserved Domains (2) summary
    COG3883
    Location:26 → 116
    CwlO1; Uncharacterized N-terminal domain of peptidoglycan hydrolase CwlO [Function unknown]
    pfam09496
    Location:124 → 195
    CENP-O; Cenp-O kinetochore centromere component

  3. XM_030246806.1 → XP_030102666.1  centromere protein O isoform X2

    UniProtKB/TrEMBL
    B8JK51
    Conserved Domains (2) summary
    COG3883
    Location:26 → 116
    CwlO1; Uncharacterized N-terminal domain of peptidoglycan hydrolase CwlO [Function unknown]
    pfam09496
    Location:124 → 195
    CENP-O; Cenp-O kinetochore centromere component

  4. XM_011243883.4 → XP_011242185.1  centromere protein O isoform X1

    Conserved Domains (2) summary
    COG3883
    Location:26 → 116
    CwlO1; Uncharacterized N-terminal domain of peptidoglycan hydrolase CwlO [Function unknown]
    pfam09496
    Location:124 → 195
    CENP-O; Cenp-O kinetochore centromere component

RNA

  1. XR_004937524.1 RNA Sequence

  2. XR_872422.4 RNA Sequence

  3. XR_381196.5 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8K015.1 GenPept UniProtKB/Swiss-Prot:Q8K015

Gene LinkOut

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