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Carhsp1 calcium regulated heat stable protein 1 [ Mus musculus (house mouse) ]

Gene ID: 52502, updated on 11-Apr-2024

Summary

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Official Symbol
Carhsp1provided by MGI
Official Full Name
calcium regulated heat stable protein 1provided by MGI
Primary source
MGI:MGI:1196368
See related
Ensembl:ENSMUSG00000008393 AllianceGenome:MGI:1196368
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Crhsp-24; D16Ertd465e; 1200011K09Rik
Summary
Predicted to enable mRNA 3'-UTR binding activity. Involved in regulation of mRNA stability. Located in P granule and cytosol. Part of cytoplasmic exosome (RNase complex). Is expressed in dorsal root ganglion; limb; neural tube; reproductive system; and urinary system. Orthologous to human CARHSP1 (calcium regulated heat stable protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 133.4), ovary adult (RPKM 91.2) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Carhsp1 in Genome Data Viewer
Location:
16 A1; 16 4.26 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (8476444..8490017, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (8658580..8672153, complement)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene ferritin light chain 2 pseudogene Neighboring gene transmembrane protein 186 Neighboring gene phosphomannomutase 2 Neighboring gene STARR-positive B cell enhancer ABC_E8616 Neighboring gene LITAF domain containing Neighboring gene ubiquitin specific peptidase 7 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:8745912-8746157 Neighboring gene STARR-seq mESC enhancer starr_40018 Neighboring gene STARR-seq mESC enhancer starr_40019 Neighboring gene predicted gene, 25805

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. CARHSP1 is required for effective tumor necrosis factor alpha mRNA stabilization and localizes to processing bodies and exosomes. Pfeiffer JR, et al. Mol Cell Biol, 2011 Jan. PMID 21078874, Free PMC Article
  2. The archetype STYX/dead-phosphatase complexes with a spermatid mRNA-binding protein and is essential for normal sperm production. Wishart MJ, et al. Proc Natl Acad Sci U S A, 2002 Feb 19. PMID 11842224, Free PMC Article
  3. A Leishmania major response locus identified by interval-specific congenic mapping of a T helper type 2 cell bias-controlling quantitative trait locus. Baguet A, et al. J Exp Med, 2004 Dec 20. PMID 15596523, Free PMC Article
  4. Gene expression in cortical interneuron precursors is prescient of their mature function. Batista-Brito R, et al. Cereb Cortex, 2008 Oct. PMID 18250082, Free PMC Article
  5. Potential target genes of EMX2 include Odz/Ten-M and other gene families with implications for cortical patterning. Li H, et al. Mol Cell Neurosci, 2006 Oct. PMID 16919471

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC101919

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables mRNA 3'-UTR binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables mRNA 3'-UTR binding ISO
Inferred from Sequence Orthology
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of mRNA stability IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of mRNA stability IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in P granule IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of cytoplasmic exosome (RNase complex) IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
calcium-regulated heat stable protein 1
Names
calcineurin substrate CRHSP-24
calcium-regulated heat-stable protein of 24 kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_025821.2 → NP_080097.1  calcium-regulated heat stable protein 1

    See identical proteins and their annotated locations for NP_080097.1

    Status: PROVISIONAL

    Source sequence(s)
    AK004711
    Consensus CDS
    CCDS27942.1
    UniProtKB/Swiss-Prot
    Q9CR86
    UniProtKB/TrEMBL
    Q3U434, Q3UD53, Q5M9P7
    Related
    ENSMUSP00000008537.9, ENSMUST00000008537.10
    Conserved Domains (1) summary
    cd04458
    Location:64 → 129
    CSP_CDS; Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein. ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    8476444..8490017 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006522347.3 → XP_006522410.1  calcium-regulated heat stable protein 1 isoform X2

    UniProtKB/TrEMBL
    Q3U434, Q3UD53
    Conserved Domains (1) summary
    cd04458
    Location:90 → 155
    CSP_CDS; Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein. ...

  2. XM_006522348.5 → XP_006522411.1  calcium-regulated heat stable protein 1 isoform X3

    UniProtKB/TrEMBL
    Q3U434, Q3UD53
    Conserved Domains (1) summary
    cd04458
    Location:84 → 149
    CSP_CDS; Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein. ...

  3. XM_006522346.4 → XP_006522409.2  calcium-regulated heat stable protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006522409.2

    UniProtKB/Swiss-Prot
    Q9CR86
    UniProtKB/TrEMBL
    Q3U434, Q3UD53, Q5M9P7
    Conserved Domains (1) summary
    cd04458
    Location:64 → 129
    CSP_CDS; Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein. ...
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CR86.1 GenPept UniProtKB/Swiss-Prot:Q9CR86

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