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Angel2 angel homolog 2 [ Mus musculus (house mouse) ]

Gene ID: 52477, updated on 25-Apr-2024

Summary

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Official Symbol
Angel2provided by MGI
Official Full Name
angel homolog 2provided by MGI
Primary source
MGI:MGI:1196310
See related
Ensembl:ENSMUSG00000026634 AllianceGenome:MGI:1196310
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
D1Ertd396e; D1Ertd654e; 2610307I21Rik; 5730410O10Rik
Summary
Predicted to enable 3'-5'-exoribonuclease activity and mRNA 3'-UTR binding activity. Predicted to be involved in 3'-UTR-mediated mRNA stabilization and negative regulation of mitotic cell cycle. Predicted to be located in Cajal body and cytoplasm. Orthologous to human ANGEL2 (angel homolog 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E14 (RPKM 13.5), CNS E18 (RPKM 13.0) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
1 H6; 1 96.28 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (190657305..190679160)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (190925108..190946963)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 39738 Neighboring gene ribosomal protein S6 kinase polypeptide 1 Neighboring gene STARR-seq mESC enhancer starr_03421 Neighboring gene predicted gene, 51740 Neighboring gene STARR-positive B cell enhancer mm9_chr1:192705345-192705646 Neighboring gene STARR-positive B cell enhancer ABC_E3353 Neighboring gene predicted gene, 53493 Neighboring gene vasohibin 2 Neighboring gene predicted gene, 31373

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Mouse centromere protein F (Cenpf) gene maps to the distal region of chromosome 1 by interspecific backcross analysis. Fowler KJ, et al. Cytogenet Cell Genet, 1998. PMID 9858811
  2. ANGEL2 phosphatase activity is required for non-canonical mitochondrial RNA processing. Clemente P, et al. Nat Commun, 2022 Sep 30. PMID 36180430, Free PMC Article
  3. A global genomic transcriptional code associated with CNS-expressed genes. Bailey PJ, et al. Exp Cell Res, 2006 Oct 1. PMID 16919269
  4. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249
  5. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ANGEL2 phosphatase activity is required for non-canonical mitochondrial RNA processing.
    Title: ANGEL2 phosphatase activity is required for non-canonical mitochondrial RNA processing.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Gene trapped (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 3'-5'-RNA exonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables mRNA 3'-UTR binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables mRNA 3'-UTR binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in 3'-UTR-mediated mRNA stabilization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in 3'-UTR-mediated mRNA stabilization ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Cajal body ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
protein angel homolog 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001199020.1 → NP_001185949.1  protein angel homolog 2 isoform 2

    See identical proteins and their annotated locations for NP_001185949.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding region which results in the use of an in-frame downstream translation initiation site, compared to variant 1. It encodes an isoform (2) with a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC112675, AK135709, CJ081516
    Consensus CDS
    CCDS56667.1
    UniProtKB/Swiss-Prot
    Q8K1C0
    Related
    ENSMUSP00000027947.7, ENSMUST00000027947.13
    Conserved Domains (1) summary
    cl00490
    Location:147 → 520
    EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily

  2. NM_001357131.1 → NP_001344060.1  protein angel homolog 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC112675
    Consensus CDS
    CCDS56667.1
    Related
    ENSMUSP00000106524.2, ENSMUST00000110899.7
    Conserved Domains (1) summary
    cl00490
    Location:147 → 520
    EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily

  3. NM_001357132.1 → NP_001344061.1  protein angel homolog 2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC112675
    Conserved Domains (1) summary
    cl00490
    Location:1 → 373
    EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily

  4. NM_001357133.1 → NP_001344062.1  protein angel homolog 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC112675
    Consensus CDS
    CCDS56667.1
    Related
    ENSMUST00000144693.2
    Conserved Domains (1) summary
    cl00490
    Location:147 → 520
    EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily

  5. NM_001357134.1 → NP_001344063.1  protein angel homolog 2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC112675
    Conserved Domains (1) summary
    cl00490
    Location:1 → 373
    EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily

  6. NM_021421.4 → NP_067396.3  protein angel homolog 2 isoform 1

    See identical proteins and their annotated locations for NP_067396.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC112675, AK158731
    Consensus CDS
    CCDS15612.1
    UniProtKB/Swiss-Prot
    Q3TEH1, Q3TL94, Q8BTT0, Q8K1C0, Q9JJB0
    Related
    ENSMUSP00000064556.8, ENSMUST00000066632.14
    Conserved Domains (1) summary
    cl00490
    Location:169 → 542
    EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily

RNA

  1. NR_151630.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC112675
    Related
    ENSMUST00000123384.8

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    190657305..190679160
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030255505.2 → XP_030111365.1  protein angel homolog 2 isoform X3

    Conserved Domains (1) summary
    cl00490
    Location:8 → 298
    EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily

  2. XM_030255501.2 → XP_030111361.1  protein angel homolog 2 isoform X2

    Conserved Domains (1) summary
    cl00490
    Location:43 → 416
    EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily

  3. XM_017321690.3 → XP_017177179.1  protein angel homolog 2 isoform X3

    Conserved Domains (1) summary
    cl00490
    Location:8 → 298
    EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily

  4. XM_036152389.1 → XP_036008282.1  protein angel homolog 2 isoform X3

    Conserved Domains (1) summary
    cl00490
    Location:8 → 298
    EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily

  5. XM_006497186.3 → XP_006497249.1  protein angel homolog 2 isoform X2

    Conserved Domains (1) summary
    cl00490
    Location:43 → 416
    EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily

  6. XM_006497184.5 → XP_006497247.1  protein angel homolog 2 isoform X1

    See identical proteins and their annotated locations for XP_006497247.1

    UniProtKB/Swiss-Prot
    Q8K1C0
    Conserved Domains (1) summary
    cl00490
    Location:147 → 520
    EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily

  7. XM_030255504.2 → XP_030111364.1  protein angel homolog 2 isoform X2

    Conserved Domains (1) summary
    cl00490
    Location:43 → 416
    EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily

  8. XM_006497183.5 → XP_006497246.1  protein angel homolog 2 isoform X1

    See identical proteins and their annotated locations for XP_006497246.1

    UniProtKB/Swiss-Prot
    Q8K1C0
    Conserved Domains (1) summary
    cl00490
    Location:147 → 520
    EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily

  9. XM_030255506.2 → XP_030111366.1  protein angel homolog 2 isoform X3

    Conserved Domains (1) summary
    cl00490
    Location:8 → 298
    EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily

RNA

  1. XR_373773.1 RNA Sequence

  2. XR_003956236.2 RNA Sequence

  3. XR_003956234.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8K1C0.1 GenPept UniProtKB/Swiss-Prot:Q8K1C0

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