Ctdsp2 CTD small phosphatase 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ctdsp2provided by MGI
Official Full Name: CTD small phosphatase 2provided by MGI
Primary source: MGI:MGI:1098748
See related: Ensembl:ENSMUSG00000078429 AllianceGenome:MGI:1098748
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: OS4; OS-4; SCP2; D10Ertd73e
Summary: Predicted to enable RNA polymerase II CTD heptapeptide repeat phosphatase activity. Acts upstream of or within negative regulation of G1/S transition of mitotic cell cycle and negative regulation of protein phosphorylation. Predicted to be located in nucleus. Is expressed in several structures, including early conceptus; genitourinary system; integumental system; respiratory system; and tail. Orthologous to human CTDSP2 (CTD small phosphatase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in lung adult (RPKM 75.2), limb E14.5 (RPKM 74.8) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 D3; 10 74.35 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (126814586..126835844)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (126978717..126999975)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CTDSP2 induces p21(Cip1/Waf1) through increasing the activity of Ras.
Title: FOXO target gene CTDSP2 regulates cell cycle progression through Ras and p21(Cip1/Waf1).

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2)

General gene information

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Markers

RH126584 (e-PCR)
- UniSTS:167036

NoName (e-PCR)
- UniSTS:236480

AI586070 (e-PCR)
- UniSTS:185854

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA polymerase II CTD heptapeptide repeat phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II CTD heptapeptide repeat phosphatase activity	ISO Inferred from Sequence Orthology more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables myosin phosphatase activity	IEA Inferred from Electronic Annotation more info
enables phosphatase activity	IEA Inferred from Electronic Annotation more info
enables phosphoprotein phosphatase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine phosphatase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within negative regulation of G1/S transition of mitotic cell cycle	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein dephosphorylation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2

Names: CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2; nuclear LIM interactor-interacting factor 2 (NLI-interacting factor 2) (Protein OS-4); small C-terminal domain phosphatase 2

NP_001106941.1

EC 3.1.3.16

NP_666124.1

EC 3.1.3.16

XP_036011783.1

EC 3.1.3.16

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001113470.1 → NP_001106941.1 carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2 isoform a

See identical proteins and their annotated locations for NP_001106941.1

Status: VALIDATED

Description

Transcript Variant: This variant (a) represents the longer transcript and encodes the longer isoform (a).

Source sequence(s)

AK049271, BB731474, BC085142

Consensus CDS

CCDS48711.1

UniProtKB/Swiss-Prot

Q8BX07

Related

ENSMUSP00000100891.3, ENSMUST00000105256.10

Conserved Domains (1) summary

TIGR02251
Location:100 → 259

HIF-SF_euk; Dullard-like phosphatase domain
NM_146012.2 → NP_666124.1 carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2 isoform b

See identical proteins and their annotated locations for NP_666124.1

Status: VALIDATED

Description

Transcript Variant: This variant (b) differs in the 5' UTR, lacks multiple 5' coding exons, and initiates translation at a downstream in-frame start codon, compared to variant a. The encoded isoform (b) has a shorter N-terminus, compared to isoform a.

Source sequence(s)

AA103008, AK049271, BB731474, CB527995

Consensus CDS

CCDS36076.1

UniProtKB/TrEMBL

Q8R3B3

Related

ENSMUSP00000100890.3, ENSMUST00000105255.3

Conserved Domains (1) summary

cl21460
Location:1 → 108

HAD_like; Haloacid Dehalogenase-like Hydrolases

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000076.7 Reference GRCm39 C57BL/6J

Range

126814586..126835844

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036155890.1 → XP_036011783.1 carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2 isoform X1

Conserved Domains (1) summary

TIGR02251
Location:87 → 246

HIF-SF_euk; Dullard-like phosphatase domain