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Mrpl48 mitochondrial ribosomal protein L48 [ Mus musculus (house mouse) ]

Gene ID: 52443, updated on 5-Mar-2024

Summary

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Official Symbol
Mrpl48provided by MGI
Official Full Name
mitochondrial ribosomal protein L48provided by MGI
Primary source
MGI:MGI:1289321
See related
Ensembl:ENSMUSG00000030706 AllianceGenome:MGI:1289321
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
L48mt; CGI-118; MRP-L48; D4Ertd786e; 1810030E20Rik; 2610028L11Rik
Summary
Located in mitochondrion. Is expressed in several structures, including early conceptus; gonad; heart; liver; and metanephros. Orthologous to human MRPL48 (mitochondrial ribosomal protein L48). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary adult (RPKM 26.8), cerebellum adult (RPKM 24.3) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
7 E2; 7 54.36 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (100194986..100257508, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (100545779..100608301, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:107685672-107685781 Neighboring gene predicted gene, 39059 Neighboring gene cytochrome c oxidase assembly factor 4 Neighboring gene STARR-positive B cell enhancer ABC_E9294 Neighboring gene STARR-positive B cell enhancer ABC_E6573 Neighboring gene cytochrome c oxidase assembly protein 20B Neighboring gene STARR-positive B cell enhancer ABC_E1738 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:107756073-107756182 Neighboring gene RAB6A, member RAS oncogene family Neighboring gene pleckstrin homology domain containing, family B (evectins) member 1 Neighboring gene predicted gene, 53385 Neighboring gene predicted gene, 35082

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Expression analysis of mammalian mitochondrial ribosomal protein genes. Cheong A, et al. Gene Expr Patterns, 2020 Dec. PMID 32987154, Free PMC Article
  2. Structure of the large ribosomal subunit from human mitochondria. Brown A, et al. Science, 2014 Nov 7. PMID 25278503, Free PMC Article
  3. Structure and Function of the Mitochondrial Ribosome. Greber BJ, et al. Annu Rev Biochem, 2016 Jun 2. PMID 27023846
  4. ATG5 is required for B cell polarization and presentation of particulate antigens. Arbogast F, et al. Autophagy, 2019 Feb. PMID 30196744, Free PMC Article
  5. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in mitochondrial translation NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in mitochondrial inner membrane NAS
Non-traceable Author Statement
more info
 PubMed 
part_of mitochondrial large ribosomal subunit ISO
Inferred from Sequence Orthology
more info
  
part_of mitochondrial large ribosomal subunit NAS
Non-traceable Author Statement
more info
 PubMed 
is_active_in mitochondrial ribosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial ribosome ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion HDA PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
large ribosomal subunit protein mL48
Names
39S ribosomal protein L48, mitochondrial

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_198831.3 → NP_942128.2  large ribosomal subunit protein mL48 isoform 1 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the protein-coding variant.
    Source sequence(s)
    AC117215
    Consensus CDS
    CCDS21502.2
    UniProtKB/Swiss-Prot
    Q4VA35, Q8JZS9
    UniProtKB/TrEMBL
    E9QPQ8
    Related
    ENSMUSP00000116090.2, ENSMUST00000150042.8
    Conserved Domains (2) summary
    smart00487
    Location:132 → 194
    DEXDc; DEAD-like helicases superfamily
    pfam00338
    Location:91 → 185
    Ribosomal_S10; Ribosomal protein S10p/S20e

RNA

  1. NR_003559.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC117215, AC124531

  2. NR_153424.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC117215, AC124531

  3. NR_153425.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC117215, AC124531

  4. NR_153426.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC117215

  5. NR_153427.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC117215

  6. NR_153428.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC117215

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    100194986..100257508 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036153237.1 → XP_036009130.1  large ribosomal subunit protein mL48 isoform X1

    UniProtKB/Swiss-Prot
    Q4VA35, Q8JZS9
    Conserved Domains (1) summary
    pfam00338
    Location:96 → 190
    Ribosomal_S10; Ribosomal protein S10p/S20e

  2. XM_036153238.1 → XP_036009131.1  large ribosomal subunit protein mL48 isoform X1

    UniProtKB/Swiss-Prot
    Q4VA35, Q8JZS9
    Conserved Domains (1) summary
    pfam00338
    Location:96 → 190
    Ribosomal_S10; Ribosomal protein S10p/S20e

  3. XM_036153236.1 → XP_036009129.1  large ribosomal subunit protein mL48 isoform X1

    UniProtKB/Swiss-Prot
    Q4VA35, Q8JZS9
    Conserved Domains (1) summary
    pfam00338
    Location:96 → 190
    Ribosomal_S10; Ribosomal protein S10p/S20e

  4. XM_006508021.5 → XP_006508084.1  large ribosomal subunit protein mL48 isoform X2

    UniProtKB/TrEMBL
    A0A140LHT6, A2VCS1
    Related
    ENSMUSP00000146539.2, ENSMUST00000146003.9
    Conserved Domains (1) summary
    pfam00338
    Location:1 → 87
    Ribosomal_S10; Ribosomal protein S10p/S20e
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8JZS9.1 GenPept UniProtKB/Swiss-Prot:Q8JZS9

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