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Tax1bp1 Tax1 (human T cell leukemia virus type I) binding protein 1 [ Mus musculus (house mouse) ]

Gene ID: 52440, updated on 5-Mar-2024

Summary

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Official Symbol
Tax1bp1provided by MGI
Official Full Name
Tax1 (human T cell leukemia virus type I) binding protein 1provided by MGI
Primary source
MGI:MGI:1289308
See related
Ensembl:ENSMUSG00000004535 AllianceGenome:MGI:1289308
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
T6bp; TXBP151; D6Ertd404e; D6Ertd772e; 1200003J11Rik; 1700069J21Rik
Summary
Enables kinase binding activity. Involved in negative regulation of NF-kappaB transcription factor activity. Is expressed in central nervous system; retina inner nuclear layer; and retina outer nuclear layer. Orthologous to human TAX1BP1 (Tax1 binding protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bladder adult (RPKM 37.5), testis adult (RPKM 35.3) and 27 other tissues See more
Orthologs
human all
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Genomic context

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Location:
6 B3; 6 25.7 cM
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (52690677..52743765)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (52713692..52766780)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene 3-hydroxyisobutyrate dehydrogenase Neighboring gene STARR-positive B cell enhancer ABC_E536 Neighboring gene predicted gene, 24355 Neighboring gene STARR-positive B cell enhancer ABC_E8104 Neighboring gene 60S ribosomal protein L24 pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:52767269-52767470 Neighboring gene JAZF zinc finger 1 Neighboring gene predicted gene, 52904 Neighboring gene STARR-seq mESC enhancer starr_15910 Neighboring gene STARR-seq mESC enhancer starr_15912 Neighboring gene predicted gene, 52903

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Multifaceted roles of TAX1BP1 in autophagy. White J, et al. Autophagy, 2023 Jan. PMID 35470757, Free PMC Article
  2. Tax1BP1 limits hepatic inflammation and reduces experimental hepatocarcinogenesis. Waidmann O, et al. Sci Rep, 2020 Oct 1. PMID 33004985, Free PMC Article
  3. TAX1BP1 overexpression attenuates cardiac dysfunction and remodeling in STZ-induced diabetic cardiomyopathy in mice by regulating autophagy. Xiao Y, et al. Biochim Biophys Acta Mol Basis Dis, 2018 May. PMID 29476905
  4. The Ubiquitin Binding Protein TAX1BP1 Mediates Autophagasome Induction and the Metabolic Transition of Activated T Cells. Whang MI, et al. Immunity, 2017 Mar 21. PMID 28314591, Free PMC Article
  5. Regulation of B cell differentiation by the ubiquitin-binding protein TAX1BP1. Matsushita N, et al. Sci Rep, 2016 Aug 12. PMID 27515252, Free PMC Article

See all (49) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TAX1BP1 downregulation by STAT3 in cardiac fibroblasts contributes to diabetes-induced heart failure with preserved ejection fraction.
    Title: TAX1BP1 downregulation by STAT3 in cardiac fibroblasts contributes to diabetes-induced heart failure with preserved ejection fraction.
  2. Multifaceted roles of TAX1BP1 in autophagy.
    Title: Multifaceted roles of TAX1BP1 in autophagy.
  3. Galectin-8 Senses Phagosomal Damage and Recruits Selective Autophagy Adapter TAX1BP1 To Control Mycobacterium tuberculosis Infection in Macrophages.
    Title: Galectin-8 Senses Phagosomal Damage and Recruits Selective Autophagy Adapter TAX1BP1 To Control Mycobacterium tuberculosis Infection in Macrophages.
  4. Tax1BP1 limits hepatic inflammation and reduces experimental hepatocarcinogenesis.
    Title: Tax1BP1 limits hepatic inflammation and reduces experimental hepatocarcinogenesis.
  5. Loss of TAX1BP1-Directed Autophagy Results in Protein Aggregate Accumulation in the Brain.
    Title: Loss of TAX1BP1-Directed Autophagy Results in Protein Aggregate Accumulation in the Brain.
  6. TAX1BP1 overexpression promoted autophagic flux, as demonstrated by increased LC3-RFP fluorescence in vitro. Furthermore, the autophagy inhibitor 3-MA abolished the protective effects of TAX1BP1 in vivo.
    Title: TAX1BP1 overexpression attenuates cardiac dysfunction and remodeling in STZ-induced diabetic cardiomyopathy in mice by regulating autophagy.
  7. These findings show that TAX1BP1 restricts ERK activation and Blimp-1 expression and regulates germinal center formation.
    Title: Regulation of B cell differentiation by the ubiquitin-binding protein TAX1BP1.
  8. These studies reveal that TAX1BP1 drives a specialized form of autophagy, providing critical amino acids that activate mTOR and enable the metabolic transition of activated T cells.
    Title: The Ubiquitin Binding Protein TAX1BP1 Mediates Autophagasome Induction and the Metabolic Transition of Activated T Cells.
  9. The induction of antibodies to an AQP4 epitope in mice immunized with the TAX1BP1-derived peptide suggests that a latent HTLV-1 infection could lead to TAX1BP1 antigen presentation and the production of anti-AQP4 antibodies in human neuromyelitis optica.
    Title: Immunization of mice with a peptide derived from the HTLV-1 TAX1BP1 protein induces cross-reactive antibodies against aquaporin 4.
  10. Antibiotics-induced 'germ free' status or the additional MyD88 deficiency significantly ameliorated TAX1BP1-KO mice's inflammatory lesions
    Title: Commensal microbiota contributes to chronic endocarditis in TAX1BP1 deficient mice.
Submit: New GeneRIF Correction See all GeneRIFs (16)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables kinase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-macromolecule adaptor activity ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin binding NAS
Non-traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of NF-kappaB transcription factor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cytoplasmic pattern recognition receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of toll-like receptor 4 signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in protein localization to phagocytic vesicle ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
is_active_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
tax1-binding protein 1 homolog
Names
TRAF6-binding protein homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001355595.1 → NP_001342524.1  tax1-binding protein 1 homolog isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC099741, AC117212, BP754065
    Conserved Domains (1) summary
    cl25732
    Location:17 → 398
    SMC_N; RecF/RecN/SMC N terminal domain

  2. NM_001355596.1 → NP_001342525.1  tax1-binding protein 1 homolog isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC099741, AC117212, BP754065
    Consensus CDS
    CCDS39490.1
    UniProtKB/Swiss-Prot
    Q3UKC1, Q91YT6, Q9CVF0, Q9DC45
    Conserved Domains (1) summary
    cl25732
    Location:17 → 460
    SMC_N; RecF/RecN/SMC N terminal domain

  3. NM_025816.3 → NP_080092.2  tax1-binding protein 1 homolog isoform 1

    See identical proteins and their annotated locations for NP_080092.2

    Status: VALIDATED

    Source sequence(s)
    AC099741, AK146076, BP754065
    Consensus CDS
    CCDS39490.1
    UniProtKB/Swiss-Prot
    Q3UKC1, Q91YT6, Q9CVF0, Q9DC45
    Related
    ENSMUSP00000079548.5, ENSMUST00000080723.11
    Conserved Domains (1) summary
    cl25732
    Location:17 → 460
    SMC_N; RecF/RecN/SMC N terminal domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    52690677..52743765
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006506370.5 → XP_006506433.1  tax1-binding protein 1 homolog isoform X1

    Conserved Domains (4) summary
    COG4372
    Location:338 → 645
    COG4372; Uncharacterized conserved protein, contains DUF3084 domain [Function unknown]
    pfam07888
    Location:125 → 408
    CALCOCO1; Calcium binding and coiled-coil domain (CALCOCO1) like
    pfam17751
    Location:17 → 120
    SKICH; SKICH domain
    pfam18112
    Location:704 → 730
    Zn-C2H2_12; Autophagy receptor zinc finger-C2H2 domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3UKC1.2 GenPept UniProtKB/Swiss-Prot:Q3UKC1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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