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Adgra1 adhesion G protein-coupled receptor A1 [ Mus musculus (house mouse) ]

Gene ID: 52389, updated on 8-May-2024

Summary

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Official Symbol
Adgra1provided by MGI
Official Full Name
adhesion G protein-coupled receptor A1provided by MGI
Primary source
MGI:MGI:1277167
See related
Ensembl:ENSMUSG00000025475 AllianceGenome:MGI:1277167
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gpr123; D7Ertd680e; 2900059M17Rik
Summary
Predicted to enable G protein-coupled receptor activity. Predicted to be involved in cell surface receptor signaling pathway. Located in glutamatergic synapse and postsynaptic density. Is expressed in several structures, including adrenal gland; central nervous system; eye; and genitourinary system. Orthologous to human ADGRA1 (adhesion G protein-coupled receptor A1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cortex adult (RPKM 8.4), frontal lobe adult (RPKM 7.5) and 8 other tissues See more
Orthologs
human all
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Genomic context

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Location:
7 F4; 7 84.89 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (139414014..139458004)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (139834097..139878088)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein L24 pseudogene Neighboring gene microRNA 6401 Neighboring gene ribosomal protein S2 pseudogene Neighboring gene kinase non-catalytic C-lobe domain (KIND) containing 1 Neighboring gene STARR-seq mESC enhancer starr_20433

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Increased Anxiety-like Behaviors in Adgra1(-/-) Male But Not Female Mice are Attributable to Elevated Neuron Dendrite Density, Upregulated PSD95 Expression, and Abnormal Activation of the PI3K/AKT/GSK-3β and MEK/ERK Pathways. Zhang XH, et al. Neuroscience, 2022 Nov 1. PMID 36115515
  2. ADGRA1 negatively regulates energy expenditure and thermogenesis through both sympathetic nervous system and hypothalamus-pituitary-thyroid axis in male mice. Zhang XH, et al. Cell Death Dis, 2021 Apr 6. PMID 33824276, Free PMC Article
  3. Method for systematic targeted isolation of homologous cDNA fragments in a multiplex format. Ohara R, et al. Biotechniques, 2004 May. PMID 15152599
  4. Correlation profiling of brain sub-cellular proteomes reveals co-assembly of synaptic proteins and subcellular distribution. Pandya NJ, et al. Sci Rep, 2017 Sep 21. PMID 28935861, Free PMC Article
  5. Deletion of the Isg15 gene results in up-regulation of decidual cell survival genes and down-regulation of adhesion genes: implication for regulation by IL-1beta. Ashley RL, et al. Endocrinology, 2010 Sep. PMID 20660068

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Increased Anxiety-like Behaviors in Adgra1(-/-) Male But Not Female Mice are Attributable to Elevated Neuron Dendrite Density, Upregulated PSD95 Expression, and Abnormal Activation of the PI3K/AKT/GSK-3beta and MEK/ERK Pathways.
    Title: Increased Anxiety-like Behaviors in Adgra1(-/-) Male But Not Female Mice are Attributable to Elevated Neuron Dendrite Density, Upregulated PSD95 Expression, and Abnormal Activation of the PI3K/AKT/GSK-3β and MEK/ERK Pathways.
  2. ADGRA1 negatively regulates energy expenditure and thermogenesis through both sympathetic nervous system and hypothalamus-pituitary-thyroid axis in male mice.
    Title: ADGRA1 negatively regulates energy expenditure and thermogenesis through both sympathetic nervous system and hypothalamus-pituitary-thyroid axis in male mice.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
enables transmembrane signaling receptor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in cell surface receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in glutamatergic synapse EXP
Inferred from Experiment
more info
 PubMed 
is_active_in glutamatergic synapse IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in postsynaptic density EXP
Inferred from Experiment
more info
 PubMed 
is_active_in postsynaptic density IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in postsynaptic density IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
adhesion G protein-coupled receptor A1
Names
G protein coupled receptor Gpr123
G protein-coupled receptor 123
probable G-protein coupled receptor 123

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_177469.3 → NP_803420.2  adhesion G protein-coupled receptor A1

    See identical proteins and their annotated locations for NP_803420.2

    Status: VALIDATED

    Source sequence(s)
    AK082207, BC056493, BE651866, BG083237
    Consensus CDS
    CCDS40171.1
    UniProtKB/Swiss-Prot
    Q8C4G9, Q8CC05
    UniProtKB/TrEMBL
    Q76JQ1
    Related
    ENSMUSP00000026548.8, ENSMUST00000026548.14
    Conserved Domains (1) summary
    cl21561
    Location:29 → 299
    7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    139414014..139458004
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006536203.5 → XP_006536266.1  adhesion G protein-coupled receptor A1 isoform X1

    See identical proteins and their annotated locations for XP_006536266.1

    UniProtKB/TrEMBL
    Q76JQ1
    Conserved Domains (2) summary
    cd14964
    Location:17 → 41
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:14 → 325
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8C4G9.1 GenPept UniProtKB/Swiss-Prot:Q8C4G9

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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