Rcn3 reticulocalbin 3, EF-hand calcium binding domain [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rcn3provided by MGI
Official Full Name: reticulocalbin 3, EF-hand calcium binding domainprovided by MGI
Primary source: MGI:MGI:1277122
See related: Ensembl:ENSMUSG00000019539 AllianceGenome:MGI:1277122
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: RLP49; D7Ertd671e; 6030455P07Rik; D530026G20Rik
Summary: Predicted to enable calcium ion binding activity. Involved in several processes, including ERAD pathway; phospholipid homeostasis; and surfactant homeostasis. Located in endoplasmic reticulum. Is expressed in several structures, including aorta; brain; gut gland; reproductive system; and trachea. Orthologous to human RCN3 (reticulocalbin 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in limb E14.5 (RPKM 194.2), ovary adult (RPKM 178.1) and 21 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 B3; 7 29.11 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (44732338..44741746, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (45082914..45092322, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Results indicate an essential role of Rcn3 in perinatal lung maturation and neonatal respiratory adaptation as well as shed additional light on the mechanism of neonatal respiratory distress syndrome development.
Title: Neonatal Respiratory Failure with Retarded Perinatal Lung Maturation in Mice Caused by Reticulocalbin 3 Disruption.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (5) 1 citation
Endonuclease-mediated (4)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D37874 (e-PCR)
- UniSTS:179567

AU015521 (e-PCR)
- UniSTS:167536

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables calcium ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium ion binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in ERAD pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in collagen biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in lung epithelium development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phospholipid homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of peptidase activity	ISO Inferred from Sequence Orthology more info
involved_in protein secretion	ISO Inferred from Sequence Orthology more info
involved_in protein transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
involved_in surfactant homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: reticulocalbin-3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001355045.1 → NP_001341974.1 reticulocalbin-3 precursor

Status: VALIDATED

Source sequence(s)

AC126256

Consensus CDS

CCDS21229.1

UniProtKB/Swiss-Prot

Q58E50, Q8BH97, Q8R137, Q99K35, Q9CTD4

UniProtKB/TrEMBL

A0A1B0GR86

Related

ENSMUSP00000148227.2, ENSMUST00000211352.2

Conserved Domains (1) summary

cd16230
Location:44 → 311

EFh_CREC_RCN3; EF-hand, calcium binding motif, found in reticulocalbin-3 (RCN-3)
NM_026555.2 → NP_080831.2 reticulocalbin-3 precursor

See identical proteins and their annotated locations for NP_080831.2

Status: VALIDATED

Source sequence(s)

AK077943, AV129283, BY248337

Consensus CDS

CCDS21229.1

UniProtKB/Swiss-Prot

Q58E50, Q8BH97, Q8R137, Q99K35, Q9CTD4

UniProtKB/TrEMBL

A0A1B0GR86

Related

ENSMUSP00000019683.4, ENSMUST00000019683.11

Conserved Domains (1) summary

cd16230
Location:44 → 311

EFh_CREC_RCN3; EF-hand, calcium binding motif, found in reticulocalbin-3 (RCN-3)