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Wwc2 WW, C2 and coiled-coil domain containing 2 [ Mus musculus (house mouse) ]

Gene ID: 52357, updated on 5-Mar-2024

Summary

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Official Symbol
Wwc2provided by MGI
Official Full Name
WW, C2 and coiled-coil domain containing 2provided by MGI
Primary source
MGI:MGI:1261872
See related
Ensembl:ENSMUSG00000031563 AllianceGenome:MGI:1261872
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
D8Ertd594e; 5330431C14Rik
Summary
Predicted to enable kinase binding activity and molecular adaptor activity. Predicted to be involved in several processes, including negative regulation of hippo signaling; negative regulation of organ growth; and negative regulation of transcription by RNA polymerase II. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Is expressed in telencephalon. Orthologous to human WWC2 (WW and C2 domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in lung adult (RPKM 18.6), testis adult (RPKM 13.9) and 26 other tissues See more
Orthologs
human all
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Genomic context

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See Wwc2 in Genome Data Viewer
Location:
8 B1.1; 8 26.91 cM
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (48279117..48443579, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (47826082..47990544, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene claudin 24 Neighboring gene claudin 22 Neighboring gene predicted gene, 39173 Neighboring gene STARR-seq mESC enhancer starr_21422 Neighboring gene STARR-seq mESC enhancer starr_21423 Neighboring gene predicted gene, 31984 Neighboring gene predicted gene, 32052 Neighboring gene STARR-seq mESC enhancer starr_21426 Neighboring gene STARR-seq mESC enhancer starr_21427 Neighboring gene STARR-seq mESC enhancer starr_21428 Neighboring gene dCMP deaminase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. WWC2 expression in the testis: Implications for spermatogenesis and male fertility. Höffken V, et al. FASEB J, 2023 May. PMID 37086090
  2. Lack of WWC2 Protein Leads to Aberrant Angiogenesis in Postnatal Mice. Brücher VC, et al. Int J Mol Sci, 2021 May 18. PMID 34070186, Free PMC Article
  3. WW and C2 domain-containing proteins regulate hepatic cell differentiation and tumorigenesis through the hippo signaling pathway. Hermann A, et al. Hepatology, 2018 Apr. PMID 29116649
  4. WWC proteins mediate LATS1/2 activation by Hippo kinases and imply a tumor suppression strategy. Qi S, et al. Mol Cell, 2022 May 19. PMID 35429439
  5. The Hippo pathway component Wwc2 is a key regulator of embryonic development and angiogenesis in mice. Hermann A, et al. Cell Death Dis, 2021 Jan 22. PMID 33483469, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. WWC2 expression in the testis: Implications for spermatogenesis and male fertility.
    Title: WWC2 expression in the testis: Implications for spermatogenesis and male fertility.
  2. The Hippo pathway component Wwc2 is a key regulator of embryonic development and angiogenesis in mice.
    Title: The Hippo pathway component Wwc2 is a key regulator of embryonic development and angiogenesis in mice.
  3. Lack of WWC2 Protein Leads to Aberrant Angiogenesis in Postnatal Mice.
    Title: Lack of WWC2 Protein Leads to Aberrant Angiogenesis in Postnatal Mice.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables kinase binding ISO
Inferred from Sequence Orthology
more info
  
enables molecular adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables molecular adaptor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cell migration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of hippo signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of organ growth IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of organ growth ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of hippo signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
protein WWC2
Names
WW domain-containing protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_133791.5 → NP_598552.2  protein WWC2

    See identical proteins and their annotated locations for NP_598552.2

    Status: VALIDATED

    Source sequence(s)
    AC110509, AC161202
    Consensus CDS
    CCDS22301.1
    UniProtKB/Swiss-Prot
    Q3UGG4, Q3UH10, Q6NXJ0, Q7TMY1, Q8CE61, Q9JJ63
    Related
    ENSMUSP00000056121.8, ENSMUST00000057561.9
    Conserved Domains (3) summary
    cd08680
    Location:699 → 822
    C2_Kibra; C2 domain found in Human protein Kibra
    pfam00397
    Location:12 → 41
    WW; WW domain
    cl01720
    Location:1088 → 1146
    Phage_Nu1; Phage DNA packaging protein Nu1

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    48279117..48443579 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036154163.1 → XP_036010056.1  protein WWC2 isoform X1

    Conserved Domains (4) summary
    cd08680
    Location:676 → 799
    C2_Kibra; C2 domain found in Human protein Kibra
    COG1196
    Location:75 → 392
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd06503
    Location:1051 → 1138
    ATP-synt_Fo_b; F-type ATP synthase, membrane subunit b
    pfam00397
    Location:36 → 65
    WW; WW domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6NXJ0.1 GenPept UniProtKB/Swiss-Prot:Q6NXJ0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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