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Klhl7 kelch-like 7 [ Mus musculus (house mouse) ]

Gene ID: 52323, updated on 5-Mar-2024

Summary

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Official Symbol
Klhl7provided by MGI
Official Full Name
kelch-like 7provided by MGI
Primary source
MGI:MGI:1196453
See related
Ensembl:ENSMUSG00000028986 AllianceGenome:MGI:1196453
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
SBBI26; D5Ertd363e; 2700038B03Rik
Summary
Predicted to enable protein homodimerization activity. Predicted to be involved in protein ubiquitination. Predicted to be located in several cellular components, including cytosol; nuclear lumen; and perinuclear region of cytoplasm. Predicted to be part of Cul3-RING ubiquitin ligase complex. Is expressed in nervous system and neural retina. Human ortholog(s) of this gene implicated in cold-induced sweating syndrome 3 and retinitis pigmentosa 42. Orthologous to human KLHL7 (kelch like family member 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E18 (RPKM 23.6), CNS E14 (RPKM 20.3) and 16 other tissues See more
Orthologs
human all
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Genomic context

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See Klhl7 in Genome Data Viewer
Location:
5 A3; 5 10.67 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (24305563..24368363)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (24100565..24163369)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene hyccin PI4KA lipid kinase complex subunit 1 Neighboring gene STARR-positive B cell enhancer ABC_E848 Neighboring gene ribosomal protein L11 pseudogene Neighboring gene STARR-seq mESC enhancer starr_12627 Neighboring gene STARR-positive B cell enhancer ABC_E6313 Neighboring gene STARR-seq mESC enhancer starr_12628 Neighboring gene predicted gene, 18038 Neighboring gene gamma-aminobutyric acid (GABA) A receptor-associated protein-like 2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_12630 Neighboring gene STARR-seq mESC enhancer starr_12632 Neighboring gene nucleoporin 42 Neighboring gene STARR-seq mESC enhancer starr_12633 Neighboring gene heat shock protein 8 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders. Li J, et al. Nat Neurosci, 2017 Aug. PMID 28671696, Free PMC Article
  2. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  3. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
  4. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249
  5. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in protein ubiquitination ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of Cul3-RING ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
kelch-like protein 7
Names
BTB/POZ domain containing protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001161800.1 → NP_001155272.1  kelch-like protein 7 isoform 2

    See identical proteins and their annotated locations for NP_001155272.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an exon in the 3' coding region, which results in a frameshift and an early stop codon, compared to variant 1. The encoded isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC118010
    Consensus CDS
    CCDS51432.1
    UniProtKB/TrEMBL
    A0A0G2JF30, G3UW75
    Related
    ENSMUSP00000129461.2, ENSMUST00000163409.5
    Conserved Domains (6) summary
    smart00612
    Location:383 → 430
    Kelch; Kelch domain
    smart00225
    Location:45 → 140
    BTB; Broad-Complex, Tramtrack and Bric a brac
    sd00038
    Location:326 → 368
    Kelch; KELCH repeat [structural motif]
    pfam00651
    Location:34 → 138
    BTB; BTB/POZ domain
    pfam01344
    Location:420 → 462
    Kelch_1; Kelch motif
    pfam07707
    Location:146 → 248
    BACK; BTB And C-terminal Kelch

  2. NM_026448.3 → NP_080724.2  kelch-like protein 7 isoform 1

    See identical proteins and their annotated locations for NP_080724.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK083358, BB841624, BQ176920
    Consensus CDS
    CCDS19114.1
    UniProtKB/Swiss-Prot
    Q8BUL5, Q9CZP4
    Related
    ENSMUSP00000030841.6, ENSMUST00000030841.10
    Conserved Domains (5) summary
    PHA03098
    Location:37 → 577
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:372 → 416
    Kelch; KELCH repeat [structural motif]
    cd18237
    Location:23 → 148
    BTB_POZ_KLHL7; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 7 (KLHL7)
    cd18447
    Location:140 → 237
    BACK_KLHL7; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 7 (KLHL7)
    pfam01344
    Location:371 → 416
    Kelch_1; Kelch motif

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    24305563..24368363
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006535753.5 → XP_006535816.1  kelch-like protein 7 isoform X1

    Conserved Domains (4) summary
    PHA03098
    Location:5 → 506
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:301 → 345
    Kelch; KELCH repeat [structural motif]
    cd18447
    Location:69 → 166
    BACK_KLHL7; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 7 (KLHL7)
    pfam01344
    Location:300 → 345
    Kelch_1; Kelch motif

RNA

  1. XR_880834.4 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BUL5.1 GenPept UniProtKB/Swiss-Prot:Q8BUL5

Gene LinkOut

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