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Anapc4 anaphase promoting complex subunit 4 [ Mus musculus (house mouse) ]

Gene ID: 52206, updated on 11-Apr-2024

Summary

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Official Symbol
Anapc4provided by MGI
Official Full Name
anaphase promoting complex subunit 4provided by MGI
Primary source
MGI:MGI:1098673
See related
Ensembl:ENSMUSG00000029176 AllianceGenome:MGI:1098673
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
APC4; D5Ertd249e; 2610306D21Rik
Summary
Predicted to enable protein phosphatase binding activity. Predicted to be involved in anaphase-promoting complex-dependent catabolic process; positive regulation of mitotic metaphase/anaphase transition; and protein K11-linked ubiquitination. Predicted to act upstream of or within cell division. Predicted to be located in nucleus. Predicted to be part of anaphase-promoting complex. Predicted to be active in nuclear periphery. Is expressed in cervico-thoracic ganglion; dorsal root ganglion; prostate gland; testis; and thoracic ganglion. Orthologous to human ANAPC4 (anaphase promoting complex subunit 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E11.5 (RPKM 38.1), CNS E14 (RPKM 29.2) and 24 other tissues See more
Orthologs
human all
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Genomic context

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Location:
5 C1; 5 28.81 cM
Exon count:
28
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (52991477..53024076)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (52834135..52866734)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_13069 Neighboring gene phosphatidylinositol 4-kinase type 2 beta Neighboring gene zinc finger, CCHC domain containing 4 Neighboring gene STARR-positive B cell enhancer ABC_E3575 Neighboring gene STARR-seq mESC enhancer starr_13070 Neighboring gene predicted gene, 30241 Neighboring gene STARR-seq mESC enhancer starr_13071 Neighboring gene STARR-seq mESC enhancer starr_13072 Neighboring gene predicted gene 43664

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. PQBP1 regulates striatum development through balancing striatal progenitor proliferation and differentiation. Liu W, et al. Cell Rep, 2023 Mar 28. PMID 36943865
  2. APC7 mediates ubiquitin signaling in constitutive heterochromatin in the developing mammalian brain. Ferguson CJ, et al. Mol Cell, 2022 Jan 6. PMID 34942119, Free PMC Article
  3. Extensive molecular differences between anterior- and posterior-half-sclerotomes underlie somite polarity and spinal nerve segmentation. Hughes DS, et al. BMC Dev Biol, 2009 May 22. PMID 19463158, Free PMC Article
  4. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article
  5. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein phosphatase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in anaphase-promoting complex-dependent catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in protein K11-linked ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein K11-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of mitotic metaphase/anaphase transition IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of anaphase-promoting complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of anaphase-promoting complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in nuclear periphery IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
anaphase-promoting complex subunit 4
Names
cyclosome subunit 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_024213.2 → NP_077175.1  anaphase-promoting complex subunit 4

    See identical proteins and their annotated locations for NP_077175.1

    Status: PROVISIONAL

    Source sequence(s)
    AC102766
    Consensus CDS
    CCDS19290.1
    UniProtKB/Swiss-Prot
    Q91W96, Q99LR5, Q9CZZ0
    UniProtKB/TrEMBL
    Q3TI31, Q3TM92
    Related
    ENSMUSP00000031072.8, ENSMUST00000031072.14
    Conserved Domains (4) summary
    pfam12894
    Location:10 → 57
    ANAPC4_WD40; Anaphase-promoting complex subunit 4 WD40 domain
    pfam12896
    Location:232 → 431
    ANAPC4; Anaphase-promoting complex, cyclosome, subunit 4
    sd00039
    Location:24 → 59
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:26 → 115
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    52991477..53024076
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q91W96.1 GenPept UniProtKB/Swiss-Prot:Q91W96

Gene LinkOut

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