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Rragd Ras-related GTP binding D [ Mus musculus (house mouse) ]

Gene ID: 52187, updated on 11-Apr-2024

Summary

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Official Symbol
Rragdprovided by MGI
Official Full Name
Ras-related GTP binding Dprovided by MGI
Primary source
MGI:MGI:1098604
See related
Ensembl:ENSMUSG00000028278 AllianceGenome:MGI:1098604
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
D4Ertd174e; 5730543C08Rik; C030003H22Rik
Summary
Predicted to enable several functions, including GTPase binding activity; guanyl ribonucleotide binding activity; and protein heterodimerization activity. Predicted to be involved in several processes, including cellular response to leucine; cellular response to leucine starvation; and positive regulation of TORC1 signaling. Predicted to be located in centrosome; cytoplasm; and nucleoplasm. Predicted to be part of Gtr1-Gtr2 GTPase complex. Predicted to be active in lysosome and nucleus. Orthologous to human RRAGD (Ras related GTP binding D). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in frontal lobe adult (RPKM 27.7), cortex adult (RPKM 13.1) and 17 other tissues See more
Orthologs
human all
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Genomic context

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See Rragd in Genome Data Viewer
Location:
4 A5; 4 14.57 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (32982998..33022180)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (32982998..33022180)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene ankyrin repeat domain 6 Neighboring gene STARR-seq mESC enhancer starr_09871 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:32993701-32993916 Neighboring gene enoyl-CoA hydratase domain-containing protein 2, mitochondrial pseudogene Neighboring gene STARR-seq mESC enhancer starr_09876 Neighboring gene STARR-seq mESC enhancer starr_09877 Neighboring gene ribosomal protein, large, P1 pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:33069120-33069321 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:33069732-33069841 Neighboring gene STARR-seq mESC enhancer starr_09878 Neighboring gene STARR-seq mESC enhancer starr_09880 Neighboring gene RIKEN cDNA 4933421O10 gene Neighboring gene ubiquitin-conjugating enzyme E2J 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Amino acids and RagD potentiate mTORC1 activation in CD8(+) T cells to confer antitumor immunity. Zhang Y, et al. J Immunother Cancer, 2021 Apr. PMID 33883257, Free PMC Article
  2. Identification of novel genetic loci for bone size and mechanosensitivity in an ENU mutant exhibiting decreased bone size. Srivastava AK, et al. J Bone Miner Res, 2005 Jun. PMID 15883645
  3. Identification of kidney mesenchymal genes by a combination of microarray analysis and Sall1-GFP knockin mice. Takasato M, et al. Mech Dev, 2004 Jun. PMID 15172686
  4. Lysosomal Signaling Licenses Embryonic Stem Cell Differentiation via Inactivation of Tfe3. Villegas F, et al. Cell Stem Cell, 2019 Feb 7. PMID 30595499
  5. Transcriptome analysis of mouse stem cells and early embryos. Sharov AA, et al. PLoS Biol, 2003 Dec. PMID 14691545, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Amino acids and RagD potentiate mTORC1 activation in CD8(+) T cells to confer antitumor immunity.
    Title: Amino acids and RagD potentiate mTORC1 activation in CD8(+) T cells to confer antitumor immunity.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GDP binding ISO
Inferred from Sequence Orthology
more info
  
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTP binding ISO
Inferred from Sequence Orthology
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity ISO
Inferred from Sequence Orthology
more info
  
enables GTPase binding ISO
Inferred from Sequence Orthology
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables molecular adaptor activity ISO
Inferred from Sequence Orthology
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cellular response to L-leucine ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to leucine starvation ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to starvation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of autophagy IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of TORC1 signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of TORC1 signaling ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of Gtr1-Gtr2 GTPase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
is_active_in lysosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in lysosome ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ras-related GTP-binding protein D
Names
rag D
ragD

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001369055.1 → NP_001355984.1  ras-related GTP-binding protein D isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AL772288
    Consensus CDS
    CCDS89724.1
    UniProtKB/Swiss-Prot
    Q6GTT2, Q7TT45, Q9CYC2
    UniProtKB/TrEMBL
    B1AWT3
    Related
    ENSMUSP00000029946.8, ENSMUST00000029946.14
    Conserved Domains (1) summary
    cd11385
    Location:118 → 292
    RagC_like; Rag GTPase, subfamily of Ras-related GTPases, includes Ras-related GTP-binding proteins C and D

  2. NM_027491.2 → NP_081767.2  ras-related GTP-binding protein D isoform 2

    See identical proteins and their annotated locations for NP_081767.2

    Status: VALIDATED

    Source sequence(s)
    AL772288, BC038137, CK387674
    Consensus CDS
    CCDS38704.1
    UniProtKB/Swiss-Prot
    Q6GTT2, Q7TT45, Q9CYC2
    UniProtKB/TrEMBL
    B1AWT2
    Related
    ENSMUSP00000095792.4, ENSMUST00000098190.10
    Conserved Domains (2) summary
    cd11385
    Location:63 → 237
    RagC_like; Rag GTPase, subfamily of Ras-related GTPases, includes Ras-related GTP-binding proteins C and D
    COG1100
    Location:63 → 237
    Gem1; GTPase SAR1 family domain [General function prediction only]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    32982998..33022180
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7TT45.2 GenPept UniProtKB/Swiss-Prot:Q7TT45

Gene LinkOut

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